Surface functional groups affect CdTe QDs behavior at mitochondrial level

Xiang, Xun; Gao, Tao; Zhang, Bo-Rui; Jiang, Feng-Lei; Liu, Yi

doi:10.1039/c8tx00160j

Cited by 19 publications

(6 citation statements)

References 39 publications

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“…However, swelling of mitochondria and endoplasmic reticulum was detected at 14 d after the last gavage. This result was in agreement with previous studies that CdTe QDs and QD705 induced mitochondrial swelling in vitro ( Lin et al, 2012 ; Xiang et al, 2018 ). Nickel nanoparticles cause mitochondrial swelling and enlargement of the endoplasmic reticulum in ovarian tissues of female rats ( Kong et al, 2016 ).…”

Section: Discussionsupporting

confidence: 94%

Effects of Oral Exposure to Mn-Doped ZnS Quantum Dots on Intestinal Tract and Gut Microbiota in Mice

et al. 2021

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Mn-doped ZnS quantum dots (QDs) with excellent optical properties have been explored in a wide range of fields. Their potential adverse effects on biological systems and human health should be evaluated before biological application. In the present study, we investigated the effect of Mn-doped ZnS QDs on the intestinal tract and gut microbiota structures at 2 h and 14 days (d) after 14 d repeated oral exposure in mice. Flame atomic absorption spectrophotometry (FAAS), histopathological examination, and transmission electron microscopy (TEM) were used to assess the absorption and toxicity of Mn-doped ZnS QDs on the intestinal tract. The 16S rRNA gene sequencing was used to evaluate the gut microbial communities. Mn-doped ZnS QDs did not accumulate in the duodenum, jejunum, ileum, or colon. The Zn content of feces was not significantly higher than in the control group. No major histological changes were found in these tissues. The intestinal microvilli remained regular, but swelling of mitochondria and endoplasmic reticulum was detected by TEM at 14 d after the last gavage. A total of 2,712 operational taxonomic units (OTUs) were generated. Mn-doped ZnS QDs treatment did not significantly change the α-diversity of Richness, Chao1, Shannon, and Simpson indexes. According to principal component analysis (PCA), Mn-doped ZnS QDs had no effect on the overall structure of the gut microbiota. No significant change occurred at the phylum level, while three genera were downregulated at 2 h and seven changed at 14 d after the last gavage. Our findings revealed that Mn-doped ZnS QDs had a little stimulation of the intestinal tract and gut microbiota, and oral administration may be a safe route for biological application (such as bioimaging and drug delivery).

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Section: Discussionsupporting

confidence: 94%

Effects of Oral Exposure to Mn-Doped ZnS Quantum Dots on Intestinal Tract and Gut Microbiota in Mice

et al. 2021

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“…On deep investigation of the top 10 “prolific authors” listed in this study, we found that Liu et al [ 20 , 21 , 22 ] mainly focused on the toxicity mechanisms of different functional cadmium-containing QDs as well as the functional research of novel carbon dots. Wang et al [ 23 , 24 ] engaged in the preparation of new carbon dots and evaluated the toxicity of the prepared carbon dots.…”

Section: Discussionmentioning

confidence: 92%

Assessment of the Toxicity of Quantum Dots through Biliometric Analysis

Zhong

Zhang

et al. 2021

IJERPH

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Along with the rapid development of nanotechnology, the biosafety of quantum dots (QDs), a widely used kind of nanoparticles, has grabbed the attentions of researchers, because QDs have excellent and unique optical properties that other commonly used nanoparticles, like walled carbon nanotubes, do not have. The understanding of the toxicity of QDs is an important premise for their application in wider fields, including biology and medicine. This study sought to analyze scientific publications on the toxicity of QDs and to construct a bibliometric model for qualitative and quantitative evaluation of these publications over the past decade, which visually presented the status quo and future development trend on the toxicological study of QDs. A search for data using the triple blind method revealed that, as of 31 December 2018, there were 5269 papers published on the toxicity of QDs. RSC ADVANCES (5-year IF, 3.096) ranked first in the number of publications. China had the largest number of publications (2233) and the highest H-index (119), but the United States was still the leading country with regards to the quality of the research. LIU Y (106 publications) published the most papers, while Hardman R (304 co-citations) had the most co-citations. The keyword “walled carbon nanotube” ranked first in the research frontier. The findings not only determine a development trend of the toxicological study of QDs, but also identify further research directions in this field.

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“…CdTe quantum dots have the advantages of high fluorescence yield, strong photostability, long fluorescence lifetime, good biocompatibility, and wide excitation wavelength range. It is widely used in biomedical fields such as biochips, protein and DNA detection, and targeted tracing [39][40][41][42].…”

Section: Discussionmentioning

confidence: 99%

A New Approach for Detection of Aflatoxin B1

Wang¹

2020

Aflatoxin B1 Occurrence, Detection and Toxicological Effects

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Aflatoxin B 1 (AFB 1 ) is harmful to human health, mainly resulting from its toxic effects on the liver. AFB 1 can lead to liver cell necrosis, hemorrhage, fibrosis, cirrhosis, etc. Acute AFB 1 exposure at high levels can lead to hepatitis, whereas chronic exposure can result in liver cancer. In the past decades, a series of methods and techniques for detecting AFB 1 , including enzyme-linked immunosorbent assay (ELISA), high-performance liquid chromatography (HPLC), and thin-layer chromatography (TLC), have been developed. This study reviewed the detection methods of AFB 1 and the corresponding utilization and summarizes all methods for evaluating the toxification of AFB 1 .

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Surface functional groups affect CdTe QDs behavior at mitochondrial level

Abstract: CdTe QDs functionalized with different groups showed different effects on mitochondrial membrane fluidity.

Cited by 19 publications

References 39 publications

Effects of Oral Exposure to Mn-Doped ZnS Quantum Dots on Intestinal Tract and Gut Microbiota in Mice

Effects of Oral Exposure to Mn-Doped ZnS Quantum Dots on Intestinal Tract and Gut Microbiota in Mice

Assessment of the Toxicity of Quantum Dots through Biliometric Analysis

A New Approach for Detection of Aflatoxin B1

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