Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes

Gao, Weiwei; Hu, Che Ming Jack; Fang, Ronnie H.; Luk, Brian T.; Su, Jing; Zhang, Liangfang

doi:10.1002/adma.201300638

Cited by 396 publications

(378 citation statements)

References 34 publications

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“…This size increase is consistent with the addition of an approximately 6 nm thick lipid membrane, confirming the membrane coating onto the exterior surface of AuNPs. 28 Meanwhile, zeta potential measurements also indicated a successful membrane coating, as the value changed from −38.6 ± 1.3 mV of bare AuNPs to −25.1 ± 0.9 mV following the coating, comparable to the value measured from the OMVs (Figure 2b). Next, the membrane coating was confirmed by examining the morphology of BM-AuNPs with transmission electron microscopy (TEM).…”

Section: Resultssupporting

confidence: 68%

Modulating Antibacterial Immunity via Bacterial Membrane-Coated Nanoparticles

et al. 2015

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Synthetic nanoparticles coated with cellular membranes have been increasingly explored to harness natural cell functions toward the development of novel therapeutic strategies. Herein, we report on a unique bacterial membrane-coated nanoparticle system as a new and exciting antibacterial vaccine. Using Escherichia coli as a model pathogen, we collect bacterial outer membrane vesicles (OMVs) and successfully coat them onto small gold nanoparticles (AuNPs) with a diameter of 30 nm. The resulting bacterial membrane-coated AuNPs (BM-AuNPs) show markedly enhanced stability in biological buffer solutions. When injected subcutaneously, the BM-AuNPs induce rapid activation and maturation of dendritic cells in the lymph nodes of the vaccinated mice. In addition, vaccination with BM-AuNPs generates antibody responses that are durable and of higher avidity than those elicited by OMVs only. The BM-AuNPs also induce an elevated production of interferon gamma (INFγ) and interleukin-17 (IL-17), but not interleukin-4 (IL-4), indicating its capability of generating strong Th1 and Th17 biased cell responses against the source bacteria. These observed results demonstrate that using natural bacterial membranes to coat synthetic nanoparticles holds great promise for designing effective antibacterial vaccines.

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Section: Resultssupporting

confidence: 68%

Modulating Antibacterial Immunity via Bacterial Membrane-Coated Nanoparticles

et al. 2015

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“…22 We recently extended the membrane-coating technique from polymeric nanoparticles to inorganic gold nanoparticles (AuNPs). 23 AuNPs have found widespread applications as imaging agents and drug carriers in biology and medicine. 24 Their modification with the entirety of a cell membrane provided improved functions and advanced biomimetic features.…”

Section: Long-circulating Carriers For Drug Deliverymentioning

confidence: 99%

Engineering red‐blood‐cell‐membrane–coated nanoparticles for broad biomedical applications

Gao

Zhang

2015

AIChE Journal

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“…The RBC-NPs showed a superior long circulation time ($10 h) in mice compared to PLGA-PEG nanoparticles. Anti-phagocytic properties demonstrated with RBC membranecoated gold nanoparticles and white blood cell membrane-coated silica particles [29,30], suggested the broad applicability of the strategy. The cell membrane coating technique adopts the same immune-evasive strategy adopted by many viruses in nature, presents a unique biomimetic approach in nanoparticle stealth functionalization [31,32].…”

Section: Introductionmentioning

confidence: 99%