Surface functionalization of zeolite-based drug delivery systems enhances their antitumoral activity in vivo

Vilaça, Natália; Bertão, Ana Raquel; Prasetyanto, Eko Adi; Granja, Sara; Costa, Marta; Fernandes, Rui; Figueiredo, Francisco; Fonseca, A.; Cola, Luisa De; Baltazar, Fátima; Neves, Isabel C.

doi:10.1016/j.msec.2020.111721

Cited by 28 publications

(23 citation statements)

References 61 publications

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“…The zeolites, another family of microporous materials that have some structural similarities with MOFs, occur naturally and have an exclusively inorganic nature. Because they usually possess higher thermal and chemical stability and are cheaper and more durable than MOFs, they are suitable for applications in a wide variety of areas that span from medicine, microfluidics, and air and water treatments to fuel cells and energy storage systems . However, zeolites have not yet been the subject of a systematic and extensive study in the area of SPEs.…”

Section: Introductionmentioning

confidence: 99%

High-Performance Room Temperature Lithium-Ion Battery Solid Polymer Electrolytes Based on Poly(vinylidene fluoride-co-hexafluoropropylene) Combining Ionic Liquid and Zeolite

Barbosa

Correia

Fernández

et al. 2021

ACS Appl. Mater. Interfaces

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The demand for more efficient energy storage devices has led to the exponential growth of lithium-ion batteries. To overcome the limitations of these systems in terms of safety and to reduce environmental impact, solid-state technology emerges as a suitable approach. This work reports on a three-component solid polymer electrolyte system based on poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP), the ionic liquid 1-butyl-3-methylimidazolium thiocyanate ([BMIM][SCN]), and clinoptilolite zeolite (CPT). The influences of the preparation method and of the dopants on the electrolyte stability, ionic conductivity, and battery performance were studied. The developed electrolytes show an improved room temperature ionic conductivity (1.9 × 10 −4 S cm −1 ), thermal stability (up to 300 °C), and mechanical stability. The corresponding batteries exhibit an outstanding room temperature performance of 160.3 mAh g −1 at a C/ 15-rate, with a capacity retention of 76% after 50 cycles. These results represent a step forward in a promising technology aiming the widespread implementation of solid-state batteries.

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Section: Introductionmentioning

confidence: 99%

High-Performance Room Temperature Lithium-Ion Battery Solid Polymer Electrolytes Based on Poly(vinylidene fluoride-co-hexafluoropropylene) Combining Ionic Liquid and Zeolite

Barbosa

Correia

Fernández

et al. 2021

ACS Appl. Mater. Interfaces

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Such framework provides zeolites with sorption, catalysis, ion-exchange or molecular sieving properties. Due to their practical features, zeolites are widely applied in environmental engineering [9], civil engineering [10,11], catalysis [12][13][14], and medicine [15][16][17]. Over 100 natural zeolites can be distinguished, among which only several types, like clinoptilolite or phillipsite, are accessible for mining and further use.…”

Section: Introductionmentioning

confidence: 99%

Recycling of Waste Solution after Hydrothermal Conversion of Fly Ash on a Semi-Technical Scale for Zeolite Synthesis

et al. 2021

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Nowadays, using fly ash for zeolites production has become a well-known strategy aimed on sustainable development. During zeolite synthesis in a hydrothermal conversion large amount of post-reaction solution is generated. In this work, the solution was used as a substrate for Na-A and Na-X zeolites synthesis at laboratory and technical scale. Obtained materials were characterized using particle size analysis, X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), transmission electron microscopy (TEM), Fourier transformed infrared spectroscopy (FTIR), and nitrogen adsorption/desorption isotherm. Produced zeolites revealed high purity (>98%) and monomineral zeolitic phase composition. The SiO2 content was in the range 39–42% and 40–38%, whereas Al2O3 content was 23–22% and 25–26% for Na-X and Na-A, respectively. TEM and BET analyses revealed Na-X zeolite pores were almost identical to commercial 13X with SBET in the range 671–734 m2/g. FTIR indicated slight differences between materials obtained at laboratory and technical scale in Si-O-(Si/Al) bridges of the zeolitic skeleton. The results showed good replicability of the laboratory process in the larger scale. The proposed method allows for waste solution reusability with a view to highly pure zeolites production in line with circular economy assumptions.

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“…Zeolites have a porous structure that can absorb various substances, making zeolites an ideal material for drug-delivery systems [120]. To prevent the untimely release of a drug, either a zeolite with an optimal pore size is selected [121], or its surface is modified with various ligands [122,123]. In general, zeolites are promising carriers for creating systems for the delivery of cytotoxic substances [124][125][126][127].…”

Section: Porous Materialsmentioning

confidence: 99%

Targeted Delivery Methods for Anticancer Drugs

Veselov

Nosyrev

Jicsinszky

et al. 2022

Cancers

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Several drug-delivery systems have been reported on and often successfully applied in cancer therapy. Cell-targeted delivery can reduce the overall toxicity of cytotoxic drugs and increase their effectiveness and selectivity. Besides traditional liposomal and micellar formulations, various nanocarrier systems have recently become the focus of developmental interest. This review discusses the preparation and targeting techniques as well as the properties of several liposome-, micelle-, solid-lipid nanoparticle-, dendrimer-, gold-, and magnetic-nanoparticle-based delivery systems. Approaches for targeted drug delivery and systems for drug release under a range of stimuli are also discussed.

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Surface functionalization of zeolite-based drug delivery systems enhances their antitumoral activity in vivo

Cited by 28 publications

References 61 publications

High-Performance Room Temperature Lithium-Ion Battery Solid Polymer Electrolytes Based on Poly(vinylidene fluoride-co-hexafluoropropylene) Combining Ionic Liquid and Zeolite

High-Performance Room Temperature Lithium-Ion Battery Solid Polymer Electrolytes Based on Poly(vinylidene fluoride-co-hexafluoropropylene) Combining Ionic Liquid and Zeolite

Recycling of Waste Solution after Hydrothermal Conversion of Fly Ash on a Semi-Technical Scale for Zeolite Synthesis

Targeted Delivery Methods for Anticancer Drugs

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