Surface implantation treatments to prevent infection complications in short term devices

Davenas, J.; Thévenard, P.; Philippe, F; Arnaud, M.N

doi:10.1016/s1389-0344(02)00037-0

Cited by 66 publications

(36 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ag ion implantation provides an effective yet simple approach to minimize bacterial adhesion [102]. Silver ion was implanted into titanium and Ti-Al-Nb alloy to improve their anti-bacterial characteristics and wear performance [103].…”

Section: Silver Ion Implantationmentioning

confidence: 99%

Ion implantation of titanium based biomaterials

Rautray

Narayanan

Kim

2011

Progress in Materials Science

270

136

View full text Add to dashboard Cite

Section: Silver Ion Implantationmentioning

confidence: 99%

Ion implantation of titanium based biomaterials

Rautray

Narayanan

Kim

2011

Progress in Materials Science

270

136

View full text Add to dashboard Cite

“…The second approach has been to attach active biocides such as antibiotics to biomaterial surfaces, or to impregnate them into the biomaterial itself. One example of the use of surface biocides is silver-processing using various techniques [10]. However, these have been disappointing in clinical use [11] and few "anti-biofilm" urinary catheters have reached the market.…”

Section: Introductionmentioning

confidence: 99%

Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity

Fisher

Hook

Ashraf

et al. 2015

Journal of Controlled Release

138

104

View full text Add to dashboard Cite

Catheter-associated urinary tract infection (CAUTI) is the commonest hospital-acquired infection, accounting for over 100,000 hospital admissions within the USA annually. Biomaterials and processes intended to reduce the risk of bacterial colonization of the catheters for long-term users have not been successful, mainly because of the need for long duration of activity in flow conditions. Here we report the results of impregnation of urinary catheters with a combination of rifampicin, sparfloxacin and triclosan. In flow experiments, the antimicrobial catheters were able to prevent colonization by common uropathogens Proteus mirabilis, Staphylococcus aureus and Escherichia coli for 7 to 12weeks in vitro compared with 1-3days for other, commercially available antimicrobial catheters currently used clinically. Resistance development was minimized by careful choice of antimicrobial combinations. Drug release profiles and distribution in the polymer, and surface analysis were also carried out and the process had no deleterious effect on the mechanical performance of the catheter or its balloon. The antimicrobial catheter therefore offers for the first time a means of reducing infection and its complications in long-term urinary catheter users.

show abstract

“…Silicone has been a widely used material for medical applications because of its flexibility, fatigue resistance, high degree of chemical inertness, thermal stability and non-toxicity. To reduce the incidence of infection complications, many approaches have been attempted in the modification of polymeric materials, such as surface heparinization (Arnander et al, 1987;Davenas et al, 2002;Sefton, 1989).…”

Section: Introductionmentioning

confidence: 99%

Nanoscale investigation on adhesion of E. coli to surface modified silicone using atomic force microscopy

Cao

Tang

Liang

et al. 2006

Biotech & Bioengineering

View full text Add to dashboard Cite

Bacterial adhesion on biomaterial surfaces is the initial step in establishing infections and leads to the formation of biofilms. In this study, silicone was modified with different biopolymers and silanes, including: heparin, hyaluronan, and self-assembled octadecyltrichlorosilane (OTS), and fluoroalkylsilane (FAS). The aim was to provide a stable and bacteria-resistant surface by varying the degree of hydrophobicity and the surface structure. The adhesion of Escherichia coli (JM 109) on different modified silicone surfaces was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). Mica, an ideal hydrophilic and smooth surface, was employed as a control specimen to study the effect of hydrophobicity and surfaces roughness on bacterial adhesion. AFM probes were coated with E. coli and the force measurements between the bacteria-immobilized tip and various materials surfaces were obtained while approaching to and retracting from the surfaces. A short-range repulsive force was observed between the FAS coated silicone and bacteria. The pull-off force of bacteria to FAS was the smallest among coated surfaces. On the other hand, heparin exhibited a long-range attractive force during approach and required a higher pull-off force in retraction. Both AFM and SEM results indicated that FAS reduced bacterial adhesion whereas heparin enhanced the adhesion compared to pure silicone. The work demonstrates that hydrophobicity cannot be used as a criterion to predict bacterial adhesion. Rather, both the native properties of the individual strain of bacteria and the specific functional structure of the surfaces determine the strength of force interaction, and thus the extent of adhesion.

show abstract

Surface implantation treatments to prevent infection complications in short term devices

Cited by 66 publications

References 7 publications

Ion implantation of titanium based biomaterials

Ion implantation of titanium based biomaterials

Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity

Nanoscale investigation on adhesion of E. coli to surface modified silicone using atomic force microscopy

Contact Info

Product

Resources

About