Surface interaction of vancomycin with polystyrene microplastics and its effect on human serum albumin

Vinod, Lydia Ann; Rajendran, Durgalakshmi; Shivashankar, Murugesh; Chandrasekaran, Natarajan

doi:10.1016/j.ijbiomac.2023.128491

Cited by 5 publications

(2 citation statements)

References 63 publications

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“…Nonetheless data reported in Table 1 clearly show that highest VCM loading was obtained at pH 5.0, confirming that not only ionic but also hydrophobic interactions are important to promote VCM loading. Moreover, higher encapsulation efficiency by PKSK-VCM as compared to PKT-VCM, may be attributed to higher hydrophobic interactions between VCM and the aromatic functional groups present in PKSK [38,90,91,106].…”

Section: Influence Of Ph On Vancomycin Loadingmentioning

confidence: 99%

“…[14,38,[84][85][86][87][88][89]. In this context, the aim of this work is to prepare polymeric DDS employing specifically customized PK able to interact with VCM through ionic and hydrophobic bonds [38,90,91]. PK was prepared according to literature procedure [68], post functionalized with sulfanilate (PKSK) or taurinate (PKT) and loaded with Vancomycin (VCM) at different pH.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Rampazzo,

Vavasori,

Ronchin

et al. 2024

Preprint

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Today, polymeric Drug Delivery Systems (DDS) appear as an interesting solution against bacterial resistance, having great advantages such as low toxicity, biocompatibility, and biodegradability. In this work, two polyketones (PK) have been post-functionalized with taurinate (PKT) or sulfanilate (PKSK) and employed as biocompatible carriers for Vancomycin against bacterial infections. Mod-ified PKs were easily prepared by Paal-Knorr reaction and loaded with Vancomycin at variable pH. All polymers were characterized by FT-IR, DSC, TGA, SEM and elemental analysis. Antimicrobial activity was tested against Gram positive Staphylococcus aureus ATCC 25923 and correlated to the different pH used for its loading (between 2.3 and 8.8). Distinctively, minimum inhibitory con-centrations achieved with PKT and PKSK loaded with Vancomycin are similar, 0.23μg/mL and 0.24μg/mL respectively, i.e. six times lower that Vancomycin alone. The use of post-functionalized aliphatic polyketones has thus been demonstrated to be a promising way to obtain very efficient polymeric DDS.

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Section: Influence Of Ph On Vancomycin Loadingmentioning

confidence: 99%