Surface ligand-assisted synthesis and biomedical applications of metal–organic framework nanocomposites

Abstract

Metal-organic framework (MOF) nanocomposites have recently gained intensive attention in biosensing and disease therapy owing to their outstanding physiochemical properties. However, the direct growth of MOF nanocomposites is usually hindered...

Copper(ii)-MOFs for bio-applications

“…One of the aspects of copper-based MOFs is the simplicity of their synthesis and this is because the synthesis has rapidly evolved to be easier, faster, and more ecological, with the aim of achieving higher yields. 16 Today, it is known that characteristics such as the type of solvent, the salt source of the metal, the metal–ligand ratio, the capping agent and the addition of a base have an effect on the synthesis, and the size and morphology of the crystals obtained. 1,17,18 Therefore, from performing solvothermal syntheses that are typically carried out in DMF and high temperatures, 19 to green syntheses carried out in aqueous or methanolic media at room temperature, together with the aforementioned characteristics, allow the control of the morphology and size of the crystals.…”

“…19 Finally, some authors report synthesis from MOFs using precursors, and this is understood as a method where micro- or nanoprecursors are used as templates to form copper MOFs. 16…”

Degradation and Erosion of Metal–Organic Frameworks: Comparative Study of a NanoMIL-100 Drug Delivery System

“…Therefore, the amount of foreign materials that needs to be administrated to the patient decreases, potentially reducing the treatment’s unwanted side effects. Additionally, the MOF’s diverse chemistry from its organic and inorganic counterparts allows for tunable functionalities for drug delivery. − As a result of these two advantages, MOFs reported in the literature have high payloads for a wide variety of active pharmaceutical ingredients − and have been applied to treat various diseases. − Multiple drug-loading and surface modification strategies have been developed. Nevertheless, due to the coordinative nature of their chemical bonds, the MOFs’ in vivo applications have faced the challenge of unpredictable and nongeneralizable degradation behaviors and associated toxicity. − Therefore, each type of MOF needs an individual analysis of the degradation mechanism and the nature of degradation products.…”

A review on zirconium-based metal–organic frameworks: synthetic approaches and biomedical applications

“…Despite the numerous review papers published on MOF materials, there is a scarcity of reviews focusing on the recent advancements in Zr-MOFs and their biomedical applications. 19–24 In this review, we have summarized different groups of Zr-based MOFs (Scheme 2) and their unique characteristics that are of benefit for biomedical applications. A comparative analysis of various MOFs and their working strategies has been performed, which will benefit researchers for further research into biomedical applications of Zr-MOFs.…”