Surface-ligand-induced crystallographic disorder–order transition in oriented attachment for the tuneable assembly of mesocrystals

Park, Bum Chul; Ko, Min Jun; Kim, Young Kwang; Kim, Gyu Won; Kim, Myeong Soo; Koo, Thomas Myeongseok; Fu, Hong En; Kim, Young Keun

doi:10.1038/s41467-022-28830-7

Cited by 16 publications

(16 citation statements)

References 40 publications

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“…Functionalization of reverse primers to the NP surface (Supporting Information, Method S6) can be identified by the increase in intensity-based diameter measurements (Figure b) and hydrodynamic diameter measurements (Supporting Information, Table S1). The Fe 3 O 4 core of the CSNPs was synthesized using a nonclassical crystallization model developed by our group in previous studies. , Owing to this method, the CSNPs exhibited superparamagnetic properties with rapid magnetic response while maintaining an almost zero magnetic coercivity ( H c = 0.29 mT) and remanence ( M r = 0.08 emu/g), which prevented aggregation by minimizing the magnetic dipole interaction (exchange coupling) between the NPs (Figure c,d). Characterization of NP morphology (Supporting Information, Method S7) using various methods confirmed the physical properties of the NP and supported their use as an ideal platform for nSLAM and the electrochemical detection of genetic material.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Nanoparticle Platform for Surface Accumulative Nucleic Acid Amplification and Rapid Electrochemical Detection: An Application to Pathogenic Coronavirus

Soh

Park

et al. 2023

ACS Sens.

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Of various molecular diagnostic assays, the real-time reverse transcription polymerase chain reaction is considered the gold standard for infection diagnosis, despite critical drawbacks that limit rapid detection and accessibility. To confront these issues, several nanoparticle-based molecular detection methods have been developed to a great extent, but still possess several challenges. In this study, a novel nucleic acid amplification method termed nanoparticle-based surface localized amplification (nSLAM) is paired with electrochemical detection (ECD) to develop a nucleic acid biosensor platform that overcomes these limitations. The system uses primer-functionalized Fe 3 O 4 −Au core−shell nanoparticles for nucleic acid amplification, which promotes the production of amplicons that accumulate on the nanoparticle surfaces, inducing significantly amplified currents during ECD that identify the presence of target genetic material. The platform, applying to the COVID-19 model, demonstrates an exceptional sensitivity of ∼1 copy/μL for 35 cycles of amplification, enabling the reduction of amplification cycles to 4 cycles (∼7 min runtime) using 1 fM complementary DNA. The nSLAM acts as an accelerator that actively promotes and participates in the nucleic acid amplification process through direct polymerization and binding of amplicons on the nanoparticle surfaces. This ultrasensitive fast-response system is a promising method for detecting emerging pathogens like the coronavirus and can be extended to detect a wider variety of biomolecules.

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Section: Resultsmentioning

confidence: 99%

Multifunctional Nanoparticle Platform for Surface Accumulative Nucleic Acid Amplification and Rapid Electrochemical Detection: An Application to Pathogenic Coronavirus

Soh

Park

et al. 2023

ACS Sens.

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“…The early stages of growth occur via the oriented assembly of aragonite nanoparticles, where assembly‐based growth has been observed for many poorly‐soluble compounds such as TiO 2 , [ 57 ] CdSe, haematite ( α ‐Fe 2 O 3 ), [ 58 ] and magnetite (Fe 3 O 4 ) [ 59 , 60 ] and is driven by short‐range attractive forces; the crystalline nanoparticles undergo translations and rotations to explore low‐energy configurations in a process that can be modified using soluble additives. [ 61 ] It is emphasized, however, that new nanoparticles only appear to form near the surface of the aragonite crystals and no burst of nanoparticle nucleation is observed in bulk solution.…”

Section: Discussionmentioning

confidence: 99%

Polyamines Promote Aragonite Nucleation and Generate Biomimetic Structures

et al. 2022

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Calcium carbonate biomineralization is remarkable for the ability of organisms to produce calcite or aragonite with perfect fidelity, where this is commonly attributed to specific anionic biomacromolecules. However, it is proven difficult to mimic this behavior using synthetic or biogenic anionic organic molecules. Here, it is shown that cationic polyamines ranging from small molecules to large polyelectrolytes can exert exceptional control over calcium carbonate polymorph, promoting aragonite nucleation at extremely low concentrations but suppressing its growth at high concentrations, such that calcite or vaterite form. The aragonite crystals form via particle assembly, giving nanoparticulate structures analogous to biogenic aragonite, and subsequent growth yields stacked aragonite platelets comparable to structures seen in developing nacre. This mechanism of polymorph selectivity is captured in a theoretical model based on these competing nucleation and growth effects and is completely distinct from the activity of magnesium ions, which generate aragonite by inhibiting calcite. Profiting from these contrasting mechanisms, it is then demonstrated that polyamines and magnesium ions can be combined to give unprecedented control over aragonite formation. These results give insight into calcite/aragonite polymorphism and raise the possibility that organisms may exploit both amine-rich organic molecules and magnesium ions in controlling calcium carbonate polymorph.

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“…Similarly, the carboxyl group in carboxylic acid can provide coordination to the nanoparticles and thereby the nanoparticles are stabilized . Surface ligands, such as acetate, polyacrylate, and Mg 2+ -adsorbed polyacrylate, can affect the oriented attachment process by adjusting the surface energy anisotropy, resulting in the tunable alignment of the nanocrystals …”

Section: Strategies For Modulating Magnetite Crystallizationmentioning

confidence: 99%

Recent Advances in Magnetite Crystallization: Pathway, Modulation, and Characterization

Shi

Feng

et al. 2023

Crystal Growth & Design

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Magnetite has wide applications in the fields of environment, biomedicine, and energy storage. Understanding the crystallization process of magnetite will improve the design and control of its properties. However, the challenge lies in determining the crystallization pathway of magnetite due to its nanosized and unstable intermediates. Recent developments in the in situ characterization techniques have shed light on this process, which has rarely been elucidated systematically. This review builds the correlation between the typical synthesis methods and the corresponding properties of magnetite. It also outlines a general multistage crystallization pathway involving a series of intermediates and explains how various strategies (e.g., pH and additives) modulate magnetite properties by influencing its intermediates during crystallization. To better illustrate published observations and reconcile conflicting perspectives, classical and state-of-the-art crystallization theories will be incorporated into each aspect. Moreover, this review highlights the importance of in situ characterization techniques, which enables the precise observation of crystallization processes. The goal of this review is to provide a fundamental understanding of magnetite crystallization and to guide the bottom-up design of magnetic materials for diverse applications.

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Surface-ligand-induced crystallographic disorder–order transition in oriented attachment for the tuneable assembly of mesocrystals

Cited by 16 publications

References 40 publications

Multifunctional Nanoparticle Platform for Surface Accumulative Nucleic Acid Amplification and Rapid Electrochemical Detection: An Application to Pathogenic Coronavirus

Multifunctional Nanoparticle Platform for Surface Accumulative Nucleic Acid Amplification and Rapid Electrochemical Detection: An Application to Pathogenic Coronavirus

Polyamines Promote Aragonite Nucleation and Generate Biomimetic Structures

Recent Advances in Magnetite Crystallization: Pathway, Modulation, and Characterization

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