Surface measurements of cingulate gyrus and memory in normal aging

Kozlovskiy, Stanislav A.; Vartanov, A.; Skvortsova, V.B.; Nikonova, E.; Sozinova, E.V.

doi:10.1016/j.ijpsycho.2010.06.077

Cited by 1 publication

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“…Memory difficulties experienced by our galactosemia subjects could be explained by the positive correlations between working memory test scores and the volumes of regions such as the hippocampus, 60 amygdala, 61 and isthmus of cingulate gyrus 60,62 ; which are all part of the large-scale neurocognitive distributed networks of working memory. Additionally, FA values of the left IFOF, which play a role in semantic working memory, correlated significantly with working memory test scores.…”

Section: Learning and Memorymentioning

confidence: 99%

Identification of neuronal structures and pathways corresponding to clinical functioning in galactosemia

Ahtam

Waisbren

Anastasoaie

et al. 2020

J of Inher Metab Disea

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Classic galactosemia (OMIM# 230400) is an autosomal recessive disorder due to galactose-1-phosphate uridyltransferase deficiency. Newborn screening and prompt treatment with a galactose-free diet prevent the severe consequences of galactosemia, but clinical outcomes remain suboptimal. Five men and five women with classic galactosemia (mean age = 27.2 ± 5.47 years) received comprehensive neurological and neuropsychological evaluations, electroencephalogram (EEG) and magnetic resonance imaging (MRI). MRI data from nine healthy controls (mean age = 30.22 ± 3.52 years) were used for comparison measures. Galactosemia subjects experienced impaired memory, language processing, visual-motor skills, and increased anxiety. Neurological examinations revealed tremor and dysarthria in six subjects. In addition, there was ataxia in three subjects and six subjects had abnormal gait. Mean full scale IQ was 80.4 ± 17.3. EEG evaluations revealed right-sided abnormalities in five subjects and bilateral abnormalities in one subject. Compared to age-and gender-matched controls, subjects with galactosemia had reduced volume in left cerebellum white matter, bilateral putamen, and left superior temporal sulcus. Galactosemia patients also had lower fractional anisotropy and higher radial diffusivity values in the dorsal and ventral language networks compared

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