A new groove-microfabrication technique of silica glass employs deposition of laser energy onto a thin layer at the glass-liquid interface. High-precision surface microfabrication of optically transparent materials, such as silica or (more generally) silicate glass, is crucial to structure the microfluidic channels used in lab-ona-chip and µ-TAS (micro total analysis systems), as well as for microoptics in photonics research and development. However, glass is a hard and brittle material, and precision surface microfabrication is very difficult. Laser-etching techniques, and in particular laser-induced backside wet etching (LIBWE), are therefore useful alternatives. LIBWE deposits laser energy onto a thin layer at the glass-liquid interface during liquid ablation. Assuming negligible UV absorption, the incident laser beam passes through the glass plate, resulting in the excitation of a dye or organic solution. If the latter-which usually strongly absorbs at the light source's operating wavelength-becomes ablated by laser irradiation of sufficient fluence, etching on the silica-glass surface layer is achieved. 1-4 We used a diode-pumped solid-state (DPSS) UV laser at 266 and 355nm: see Figure 1(a). 5, 6 As single-mode DPSS lasers possess excellent beam quality, as well as high pulse-repetition rates (5-100kHz), the laser beam (characterized by a small laser-spot size at a high repetition rate) is readily available in ambientair conditions and can be focused with a simple lens. These lasers can therefore handle surface microfabrication on material substrates reliably, rapidly, easily, and at high throughput. Up to a repetition rate of 100kHz, LIBWE works under optimized laser conditions. Figure 1(b) shows a good response of pressure signals to laser irradiation at 100kHz, achieved in 45.5s. 7