Surface modification – A step forward to overcome the current challenges in orthopedic industry and to obtain an improved osseointegration and antimicrobial properties

Florea, Denisa Alexandra; Albuleț, Delia; Grumezescu, Alexandru Mihai; Andronescu, Ecaterina

doi:10.1016/j.matchemphys.2019.122579

Cited by 51 publications

(38 citation statements)

References 69 publications

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“…The success of a metallic implant in the human body is directly related to biocompatibility and reduced immune response. Despite the widespread use of metal implants, they have some disadvantages and although being biotolerable or bioinert, metal alloys can release particles due to wear or chemical degradation, which could cause different pathologies, requiring a posterior removal of the implant ( 61 ), and even stimulate the metabolic pathways of many cell types, including osteoclasts, osteoblasts, lymphocytes, macrophages, or fibroblasts ( 62 ). In addition, the failure of implants can occur due to the difference between the elastic modules of the metallic implants and the host tissue, causing the phenomenon known as “stress shielding” ( 63 ).…”

Section: Role Of Metallic Biomaterials In Orthopedics and Dentistrymentioning

confidence: 99%

Biomaterials for bone regeneration: an orthopedic and dentistry overview

Girón

Kerstner

Medeiros

et al. 2021

Braz J Med Biol Res

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Because bone-associated diseases are increasing, a variety of tissue engineering approaches with bone regeneration purposes have been proposed over the last years. Bone tissue provides a number of important physiological and structural functions in the human body, being essential for hematopoietic maintenance and for providing support and protection of vital organs. Therefore, efforts to develop the ideal scaffold which is able to guide the bone regeneration processes is a relevant target for tissue engineering researchers. Several techniques have been used for scaffolding approaches, such as diverse types of biomaterials. On the other hand, metallic biomaterials are widely used as support devices in dentistry and orthopedics, constituting an important complement for the scaffolds. Hence, the aim of this review is to provide an overview of the degradable biomaterials and metal biomaterials proposed for bone regeneration in the orthopedic and dentistry fields in the last years.

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Section: Role Of Metallic Biomaterials In Orthopedics and Dentistrymentioning

confidence: 99%

Biomaterials for bone regeneration: an orthopedic and dentistry overview

Girón

Kerstner

Medeiros

et al. 2021

Braz J Med Biol Res

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“…Between the methods of obtaining thin films exist the chemical and physical processes, the most employed being the so-called sputtering, an advantage of the technique are: high homogeneity of the coatings, high chemical and mechanical stability of the same, possibility of oversized coating substrates at a relatively low cost [8][9][10][11]. The steel AISI 316LVM undergoes pitting corrosion, which has lead to its replacement with other materials as titanium alloys [12][13][14][15]. It generates the inert character as it does not react against bone, tissue, or body fluids.…”

Section: Researchmentioning

confidence: 99%

Sliding and Corrosion Wear of Magnetron Sputtered TiO2 Films Deposited with Different Argon and Oxygen Mixtures

Aperador¹,

Bautista-Ruiz²,

Caicedo³

2021

Tribol. Ind.

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Were produced TiO2 thin coatings prepared, on substrates pure Titanium using a deposition by magnetron sputtering technique, the percentage of oxygen was varied, to study the behavior in terms of friction coefficient corrosive fluids such as those related to the human body. Electrochemical Impedance Spectroscopy (EIS), wear tests with a tribometer, were performed to obtain the tribo-corrosion mechanism of deterioration, taking into account the dual corrosion wear system. The phases were identified by X-ray Photoelectron Spectroscopy (XPS) high resolution. It is determined through the tests performed that the surface treatment has a different effect for each percentage of oxygen influenced by the simulated body environments. The wear performance analysis indicated that the TiO2 film's protection had increased as the percentage of oxygen in the gas mixture (Ar/O2) varied and other synthesis parameters such as deposition time, target power, and substrate temperature remained constant.

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“…Osseointegration is often defined as the “direct connection between ordered, living bone and the surface of a load‐carrying implant” 7 and is critical, especially in load‐bearing applications, to enhance implant stability, promote new bone formation, and sustain long‐term functionality 7,13,14 . The first stage of osseointegration occurs once an implant is inserted and the host has a primary response to that foreign object, the second and third stages of osseointegration occur once osteogenesis and remodeling processes have taken place 15 . After the body undergoes an inflammation process, there is a biological response that takes place which results from the activation of specific molecules and proteins such as osteogenic growth factors, and this is critical in contributing to the differentiation of mesenchymal stem cells into fully matured osteoblasts that will further form new bone 6,15 .…”

Section: Introductionmentioning

confidence: 99%

“…The first stage of osseointegration occurs once an implant is inserted and the host has a primary response to that foreign object, the second and third stages of osseointegration occur once osteogenesis and remodeling processes have taken place 15 . After the body undergoes an inflammation process, there is a biological response that takes place which results from the activation of specific molecules and proteins such as osteogenic growth factors, and this is critical in contributing to the differentiation of mesenchymal stem cells into fully matured osteoblasts that will further form new bone 6,15 . Thus, in order to achieve maximum efficacy of an implant, several factors must be considered including implant biocompatibility, osseointegration capability, material mechanical properties, corrosion resistance, and wear resistance.…”

Section: Introductionmentioning

confidence: 99%

Surface modifications to enhance osseointegration–Resulting material properties and biological responses

2021

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As life expectancy and the age of the general population increases so does the need for improved implants. A major contributor to the failure of implants is poor osseointegration, which is typically described as the direct connection between bone and implant. This leads to unnecessary complications and an increased burden on the patient population. Modification of the implant surfaces through novel techniques, such as varying topography and/or applying coatings, has become a popular method to enhance the osseointegration capability of implants. Recent research has shown that particular surface features influence how bone cells interact with a material; however, it is unknown which exact features achieve optimal bone integration. In this review, current methods of modifying surfaces will be highlighted, and the resulting surface characteristics and biological responses are discussed. Review of the current strategies of surface modifications found that many coating types are more advantageous when used in combination; however, finding a surface modification that utilizes the mutual beneficial effects of important surface characteristics while still maintaining commercial viability is where future challenges exist.

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Surface modification – A step forward to overcome the current challenges in orthopedic industry and to obtain an improved osseointegration and antimicrobial properties

Cited by 51 publications

References 69 publications

Biomaterials for bone regeneration: an orthopedic and dentistry overview

Biomaterials for bone regeneration: an orthopedic and dentistry overview

Sliding and Corrosion Wear of Magnetron Sputtered TiO2 Films Deposited with Different Argon and Oxygen Mixtures

Surface modifications to enhance osseointegration–Resulting material properties and biological responses

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