Surface Modification and Biological Approaches for Tackling Titanium Wear-Induced Aseptic Loosening

Vishnu, Jithin; Manivasagam, Geetha

doi:10.1007/s40735-021-00474-y

Cited by 23 publications

(8 citation statements)

References 129 publications

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“…Ion implantation is a well-established method in tuning material and surface characteristics [ 62 , 63 , 64 ]. Indeed, Kupferer et al have recently reported that low-energy low-fluence ion implantation of TNSs not only promotes smoothing and surface relaxation, it is further connected to a considerable change in chemical composition and electrical conductivity [ 49 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

et al. 2022

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Interfacing neurons persistently to conductive matter constitutes one of the key challenges when designing brain-machine interfaces such as neuroelectrodes or retinal implants. Novel materials approaches that prevent occurrence of loss of long-term adhesion, rejection reactions, and glial scarring are highly desirable. Ion doped titania nanotube scaffolds are a promising material to fulfill all these requirements while revealing sufficient electrical conductivity, and are scrutinized in the present study regarding their neuron–material interface. Adsorption of laminin, an essential extracellular matrix protein of the brain, is comprehensively analyzed. The implantation-dependent decline in laminin adsorption is revealed by employing surface characteristics such as nanotube diameter, ζ-potential, and surface free energy. Moreover, the viability of U87-MG glial cells and SH-SY5Y neurons after one and four days are investigated, as well as the material’s cytotoxicity. The higher conductivity related to carbon implantation does not affect the viability of neurons, although it impedes glial cell proliferation. This gives rise to novel titania nanotube based implant materials with long-term stability, and could reduce undesirable glial scarring.

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Section: Discussionmentioning

confidence: 99%

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

et al. 2022

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“…One of the ways to increase the abrasion resistance and thus the corrosion resistance is to modify the surface layer. Thermal and anodic oxidation and ion implantation are the main subjects of research [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…As stated before, there is concern regarding the wear resistance of the oxide layer. This is where nitrogen ion implantation can be helpful [ 5 , 7 , 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Use of Electrochemical Methods to Determine the Effect of Nitrides of Alloying Elements on the Electrochemical Properties of Titanium β-Alloys

Jírů

Hybášek

Vlcak

et al. 2023

IJMS

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Titanium beta alloys represent the new generation of materials for the manufacturing of joint implants. Their Young’s modulus is lower and thus closer to the bone tissue compared to commonly used alloys. The surface tribological properties of these materials should be improved by ion implantation. The influence of this surface treatment on corrosion behaviour is unknown. The surface of Ti-36Nb-6Ta, Ti-36Nb-4Zr, and Ti‑39Nb titanium β-alloys was modified using nitrogen ion implantation. X-ray photoelectron spectroscopy was used for surface analysis, which showed the presence of titanium, niobium, and tantalum nitrides in the treated samples and the elimination of less stable oxides. Electrochemical methods, electrochemical impedance spectra, polarisation resistance, and Mott–Schottky plot were measured in a physiological saline solution. The results of the measurements showed that ion implantation does not have a significant negative effect on the corrosion behaviour of the material. The best results of the alloys investigated were achieved by the Ti-36Nb-6Ta alloy. The combination of niobium and tantalum nitrides had a positive effect on the corrosion resistance of this alloy. After surface treatment, the polarization resistance of this alloy increased, 2.3 × 106 Ω·cm2, demonstrating higher corrosion resistance of the alloy. These results were also supported by the results of electrochemical impedance spectroscopy.

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“…Recently, an in-situ synthesis mechanism is being practised to prepare Ti-Mo composites strengthened by extra precipitated ceramic reinforcements [15], to meet the increasing demand for improved wear resistance in the clinic. Many clinical cases have reported that their success rates are significantly restricted by insufficient wear resistance, since the wear debris of Ti is possible to activate pro-inflammatory cytokines, including IL1β, (TNF)-α, and IL6, leaving undesirable osteolytic events [16]. A good example of the in-situ synthesis of Ti-Mo composites is to replace Mo with Molybdenum Carbide (Mo2C) as raw material to achieve a Ti-Mo matrix reinforced by precipitated TiC particles, forming Ceramic Particle Reinforced Metal Matrix Composites (CPRMMCs) [17].…”

Section: Introductionmentioning

confidence: 99%

In-situ formation of Ti-Mo biomaterials by selective laser melting of Ti/Mo and Ti/Mo2C powder mixtures: A comparative study on microstructure, mechanical and wear performance, and thermal mechanisms

Shi

Yang

Sun

et al. 2022

Journal of Materials Science & Technology

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Surface Modification and Biological Approaches for Tackling Titanium Wear-Induced Aseptic Loosening

Cited by 23 publications

References 129 publications

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

The Use of Electrochemical Methods to Determine the Effect of Nitrides of Alloying Elements on the Electrochemical Properties of Titanium β-Alloys

In-situ formation of Ti-Mo biomaterials by selective laser melting of Ti/Mo and Ti/Mo2C powder mixtures: A comparative study on microstructure, mechanical and wear performance, and thermal mechanisms

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