Surface modification for improving immunoassay sensitivity

Zhou, Xiaohu; Zheng, Bo

doi:10.1039/d2lc00811d

Cited by 10 publications

(6 citation statements)

References 176 publications

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“…Repli-chip in mesodermal cell (ENCFF001JUT) was obtained from EncodeProject. A list of curated ICRs was obtained from (108).…”

Section: Public Datasetsmentioning

confidence: 99%

CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses

Vukic,

Chouaref,

Della Chiara

et al. 2024

Sci. Adv.

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Disruption of cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA hypomethylation, but the impact of DNA methylation loss on transcription has not been investigated. Here, we show that CDCA7 is critical for maintaining global DNA methylation levels across multiple tissues in vivo. A pathogenic Cdca7 missense variant leads to the formation of large, aberrantly hypomethylated domains overlapping with the B genomic compartment but without affecting the deposition of H3K9 trimethylation (H3K9me3). CDCA7-associated aberrant DNA hypomethylation translated to localized, tissue-specific transcriptional dysregulation that affected large gene clusters. In the brain, we identify CDCA7 as a transcriptional repressor and epigenetic regulator of clustered protocadherin isoform choice. Increased protocadherin isoform expression frequency is accompanied by DNA methylation loss, gain of H3K4 trimethylation (H3K4me3), and increased binding of the transcriptional regulator CCCTC-binding factor (CTCF). Overall, our in vivo work identifies a key role for CDCA7 in safeguarding tissue-specific expression of gene clusters via the DNA methylation pathway.

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“…Repli-chip in mesodermal cell (ENCFF001JUT) was obtained from EncodeProject. A list of curated ICRs was obtained from (108).…”

Section: Public Datasetsmentioning

confidence: 99%

CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses

Vukic,

Chouaref,

Della Chiara

et al. 2024

Sci. Adv.

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“…Meanwhile, AI can be utilized for tasks of data mining, feature extraction, specimen classification, and intelligent forecasting tasks. 121,122 Generally, these tasks represent a unidirectional flow from the physical domain to the information domain. In the context of micro-electromechanical engineering, MNRs, which possess the capacity for energy transformation and move according to predetermined human inputs or machine intelligence, can perceive the environment for themselves.…”

Section: Sensingmentioning

confidence: 99%

AI-enhanced biomedical micro/nanorobots in microfluidics

Dong,

Lin,

Tao

et al. 2024

Lab Chip

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“…The micromotors have been designed to carry and release specific types of nanoparticles or other functional materials that aid in the degradation of pollutants and removal of harmful substances from the environment. [112][113][114] In a noteworthy study, Wu et al, engineered buoyant force-propelled micromotors, adorned with bimetallic catalysts (Ag and Pt NPs) on a glassy carbon bead matrix (GCB) for efficient degradation of the methylene blue (MB). [77] The micromotors were fabricated by ini-tially functionalizing the Au─Ag metal on partially coated PDA polymer to get GCB@PDA/Au─Ag/PDA.…”

Section: Environmental Remediationmentioning

confidence: 99%

Buoyancy‐Driven Micro/‐Nanomotors: From Fundamentals to Applications

Shukla,

Bhandari,

Mitra

et al. 2024

Small

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The progression of self‐powered micro/‐nanomotors (MNMs) has rapidly evolved over the past few decades, showing applications in various fields such as nanotechnology, biomedical engineering, microfluidics, environmental science, and energy harvesting. Miniaturized MNMs transduce chemical/biochemical energies into mechanical motion for navigating through complex fluidic environments with directional control via external forces fields such as magnetic, photonic, and electric stimuli. Among various propulsion mechanisms, buoyancy‐driven MNMs have received noteworthy recognition due to their simplicity, efficiency, and versatility. Buoyancy force‐driven motors harness the principles of density variation‐mediated force to overcome fluidic resistance to navigate through complex environments. Restricting the propulsion in one direction helps to control directional movement, making it more efficient in isotropic solutions. The changes in pH, ionic strength, chemical concentration, solute gradients, or the presence of specific molecules can influence the motion of buoyancy‐driven MNMs as evidenced by earlier reports. This review aims to provide a fundamental and detailed analysis of the current state‐of‐the‐art in buoyancy‐driven MNMs, aiming to inspire further research and innovation in this promising field.

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Surface modification for improving immunoassay sensitivity

Abstract: In this review, we summarize the recent progress in surface modification strategies for improving the sensitivity of immunoassays, including antifouling coatings to reduce background noise and nanostructured surfaces to amplify the signals.

Cited by 10 publications

References 176 publications

CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses

CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses

AI-enhanced biomedical micro/nanorobots in microfluidics

Buoyancy‐Driven Micro/‐Nanomotors: From Fundamentals to Applications

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