Surface modification of a synthetic polyurethane by plasma glow discharge: Preparation and characterization of bioactive monolayers

Sartori, Susanna; Rechichi, A.; Vozzi, Giovanni; D’Acunto, Mario; Heine, Elisabeth; Giusti, P.; Ciardelli, Gianluca

doi:10.1016/j.reactfunctpolym.2007.12.002

Cited by 80 publications

(77 citation statements)

References 23 publications

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“…Indeed, the roughest morphology is observed for sample 3 compared to the others showing a brush-like pattern which forms an active support for subsequent modifications. Similar finding was reported on AA-grafted polyurethane [42]. Quantitatively, based on the gravimetric data, the average graft density of PAA, assuming uniform distribution, is estimated to be «185 |jigcm -2 , which is higher than the average values attained in similar works devoted to surface grafting of PAA [41,43,44].…”

Section: Surface Morphology Analysissupporting

confidence: 82%

An in vitro bacterial adhesion assessment of surface-modified medical-grade PVC

Asadinezhad

Novák

Lehocký

et al. 2010

Colloids and Surfaces B: Biointerfaces

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A B S T R A C TMedical-grade polyvinyl chloride was surface modified by a multistep physicochemical approach to improve bacterial adhesion prevention properties. This was fulfilled via surface activation by diffuse coplanar surface barrier discharge plasma followed by radical graft copolymerization of acrylic acid through surfaceinitiated pathway to render a structured high density brush. Three known antibacterial agents, bronopol, benzalkonium chloride, and chlorhexidine, were then individually coated onto functionalized surface to induce biological properties. Various modern surface probe techniques were employed to explore the effects of the modification steps. In vitro bacterial adhesion and biofilm formation assay was performed. Escherichia coli strain was found to be more susceptible to modifications rather than Staphylococcus aureus as up to 85% reduction in adherence degree of the former was observed upon treating with above antibacterial agents, while only chlorhexidine could retard the adhesion of the latter by 50%. Also, plasma treated and graft copolymerized samples were remarkably effective to diminish the adherence of E. coli.

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Section: Surface Morphology Analysissupporting

confidence: 82%

An in vitro bacterial adhesion assessment of surface-modified medical-grade PVC

Asadinezhad

Novák

Lehocký

et al. 2010

Colloids and Surfaces B: Biointerfaces

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“…Various binding sites on the polymer surface have been proposed including groups such as hydroxyl, carbonyl (Mitchell et al 2005), carboxyl (Sartori et al 2008), and amine (Martinez et al 2000). One can speculate that these groups are created by the free radicals produced by the ion beam interactions with the polymer.…”

Section: Retention Of Activity After Freeze Dryingmentioning

confidence: 99%

Plasma modified surfaces for covalent immobilization of functional biomolecules in the absence of chemical linkers: towards better biosensors and a new generation of medical implants

2010

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Plasma modification and plasma polymer deposition are valuable technologies for the preparation of surfaces for the covalent binding of biomolecules for applications such as biosensors, medical prostheses, and diagnostic devices as well as surfaces for enzyme-mediated reactions. Covalency is conveniently tested by the ability of the surface to retain the attached molecules after vigorous washing with sodium dodecyl sulphate (SDS). Covalency is indicated if the fraction of protein retained lies above the curve characteristic of physisorption. Confidence in covalency is strengthened when the washing protocol is aggressive enough to remove all adsorbed protein from a control significantly more hydrophobic than the test surface. The use of linker chemistry to space the molecules from the surface is in some cases beneficial. However, the use of linker chemistry is not necessary to retain molecular function for long periods when the polymer surface is modified by energetic bombardment. The energetic bombardment retains hydrophilicity of the surface by crosslinking the subsurface, and this appears to facilitate retention of protein function. Energetic bombardment also increases the functional life of molecules immobilized and then freeze dried on plasma-modified surfaces. Analysis of the surfaces shows that the covalent binding mechanism is related to the presence of free radicals on the surface and in the subsurface regions. The unpaired electrons associated with the radicals appear to be mobile within the modified region and can diffuse to the surface to take part in binding interactions. Proactive implantable devices can make use of these principles of covalent attachment by seeding the surface of an implant with a biomolecule that elicits the desired interaction with cells and prevents undesirable responses.

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“…All of mentioned shapes have to possess interconnected open-cell micropores to enhance the compliance and increase transmural tissue ingrowths from the surrounding tissues [6]. The micropore-directed fabrication techniques include: electrospinning [7], thermally induced phase separation (TIPS) [8] and solvent casting-particulate leaching (SC/PL) [9,10]. Electrospinning is a unique and versatile process to produce polymeric fibres suitable for vascular graft prostheses [5].…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid in Polyurethane Systems for Tissue Engineering

Kucińska-Lipka¹,

St.²,

Janik³

et al. 2016

ChChT

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Abstract. The introduction of the paper was devoted to the main items of Tissue Engineering (TE) and the way of porous structure obtaining as scaffolds. Furthermore, the significant role of the scaffold design in TE was described. It was shown, that properly designed polyurethanes (PURs) find application in TE due to the proper physicochemical, mechanical and biological properties. Then the use of L-ascorbic acid (L-AA) in PUR systems for TE was described. L-AA has been applied in this area due to its suitable biological characteristics and antioxidative properties. Moreover, L-AA influences tissue regeneration due to improving collagen synthesis, which is a primary component of the extracellular matrix (ECM). Modification of PUR with L-AA leads to the materials with higher biocompatibility and such system is promising for TE applications.

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Surface modification of a synthetic polyurethane by plasma glow discharge: Preparation and characterization of bioactive monolayers

Cited by 80 publications

References 23 publications

An in vitro bacterial adhesion assessment of surface-modified medical-grade PVC

An in vitro bacterial adhesion assessment of surface-modified medical-grade PVC

Plasma modified surfaces for covalent immobilization of functional biomolecules in the absence of chemical linkers: towards better biosensors and a new generation of medical implants

Ascorbic Acid in Polyurethane Systems for Tissue Engineering

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