Surface Modification of Absorbable Magnesium Stents by Reactive Ion Etching

Galvin, Emmet; Morshed, Muhammad; Cummins, Cian; Daniels, Stephen; Lally, Caitríona; Donald, Bryan J. Mac

doi:10.1007/s11090-013-9477-1

Cited by 15 publications

(10 citation statements)

References 40 publications

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“…The corrosion-induced reduction in the stress-strain response ( Figure 2) and mechanical properties (Figure 3) observed in the corrosion tests likely resulted from the reduction in specimen cross-section and the influence of stress concentrations in corroded regions, as reported in previous studies [17].…”

Section: Discussionsupporting

confidence: 67%

“…Metallographic analysis confirmed that dog-bone and wire specimens had comparable average grain sizes of 10 to 15 µm following mechanical processing and T6 heat treatment. All specimens were finished by phosphoric acid etching and reactive ion etching surface treatments, as described in earlier work [17] and had an average surface roughness of 0.17 µm, as measured by an atomic force microscope (Nano-RTM O-020, Pacific Nanotechnology, Santa Clara, CA, USA). Finished dog-bone specimens had an outer diameter (OD) of 2.09 mm, wall thickness of 0.14 mm, and a strut width of 0.12 mm while wire specimens had an OD of 2 mm and length of 10 mm, as measured by a scanning electron microscope (Leo 440 Stereoscan, Leica Cambridge Ltd., Cambridge, UK).…”

Section: Preparation Of Specimens and Mechanical Testingmentioning

confidence: 99%

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In Vitro Corrosion and Biological Assessment of Bioabsorbable WE43 Mg Alloy Specimens

Galvin

Jaiswal

Lally

et al. 2017

JMMP

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Bioabsorbable magnesium (Mg) alloys have several advantages in biomedical implant applications as they reduce certain risks associated with conventional permanent implants. However, limited information is available for WE43 Mg alloy specimens with comparable size to that of biomedical implants such as cardiovascular stents and orthopaedic wires. The present work examines the corrosion and biological properties of WE43 stent precursor tubes and wire specimens suited for orthopaedic implants. The corrosion-induced loss of mechanical integrity as well as the corrosion-induced changes in surface morphology of the specimens are elucidated and compared. Cell viability assays were performed with human umbilical vein endothelial cells (HUVECs). It was observed that Mg ions released from the WE43 alloy acted as a growth stimulator of HUVECs.

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Section: Discussionsupporting

confidence: 67%

Section: Preparation Of Specimens and Mechanical Testingmentioning

confidence: 99%

In Vitro Corrosion and Biological Assessment of Bioabsorbable WE43 Mg Alloy Specimens

Galvin

Jaiswal

Lally

et al. 2017

JMMP

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“…The findings will help direct future design efforts towards the minimisation of plastic strain during device manufacture, deployment and in-service, in order to reduce corrosion rates and prolong the mechanical integrity of magnesium devices. Improvements in the corrosion performance and biocompatibility of magnesium stents are needed and may be achieved through improved stent design, advances in metallurgy and materials processing, better surface treatments and coating strategies [32,33]. …”

Section: Discussionmentioning

confidence: 99%

A strain-mediated corrosion model for bioabsorbable metallic stents

Galvin

O’Brien

Cummins³

et al. 2017

Acta Biomaterialia

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“…Most research was done on established materials like WE43, AZ31 or modifications of such alloys. Different magnesium alloys, surface modifications and coatings with or without anti‐proliferative substances have been analyzed in vitro as well as in vivo . Recently, Biotronik achieved CE‐marking for their degradable coronary stent “Magmaris.”…”

Section: Introductionmentioning

confidence: 99%

New methods for in vivo degradation testing of future stent materials

Bartosch

Peters

Koerner

et al. 2017

Materials & Corrosion

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Selection of a degradable material for cardiovascular stent application is a difficult task. Beside various alloys, different processing routes, annealing and surface treatment options, and coatings are available. Unfortunately, the in vivo properties of materials cannot be reliably predicted in vitro. In order to narrow down the selection there is a great need for an easy and fast in vivo pre‐selection method for possible stent materials. In this study we tested an approach presented by another group. It was compared to our new approach, the Carrier Stent. Here, several material samples are sewn on an inert, polymeric stent. It can be implanted in virtually every vessel of an animal model. It enables testing of different materials at the same location. Mg10Gd was chosen as an example for a degradable alloy for future stent applications. Wires were produced by drawing, annealed, etched, and analyzed. Due to the short wire lengths, a new clamping method for tensile tests was developed. Different heat treatments and etching processes were evaluated prior to the implantations. Both direct wire implantation and carrier stent implantation were performed and compared.

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Surface Modification of Absorbable Magnesium Stents by Reactive Ion Etching

Cited by 15 publications

References 40 publications

In Vitro Corrosion and Biological Assessment of Bioabsorbable WE43 Mg Alloy Specimens

In Vitro Corrosion and Biological Assessment of Bioabsorbable WE43 Mg Alloy Specimens

A strain-mediated corrosion model for bioabsorbable metallic stents

New methods for in vivo degradation testing of future stent materials

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