Surface Modification of Aliphatic Polyester to Enhance Biocompatibility

Bu, Yazhong; Ma, Junxuan; Bei, Jianzhong; Wang, Shenguo

doi:10.3389/fbioe.2019.00098

Cited by 58 publications

(36 citation statements)

References 69 publications

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“…To verify that the enzymes were successfully immobilized on the modified carrier, SEM and FTIR spectroscopy were used and the morphologies of PGMA, Ps-PGMA, NH 2 -Ps-PGMA, and NH 2 -Ps-PGMA-GOx/CAT are presented in Figures 4A-D. Initially, the surface of unmodified PGMA, which had a porous structure with numerous cavities, became smoother following the use of the plasma systems. After plasma treatment, a layered structure with wrinkles was clearly observed on Ps-PGMA, indicating that the plasma subsequently produced conformal coatings on the surface of PGMA, which were in accordance with those reported by another study (Bu et al, 2019). The results suggest that the physical morphology and chemical groups were changed by plasma treatment (Mostofi Sarkari et al, 2019).…”

Section: Optimization Of Immobilization Conditions and Characterizationsupporting

confidence: 90%

Coupling and Regulation of Porous Carriers Using Plasma and Amination to Improve the Catalytic Performance of Glucose Oxidase and Catalase

Liao

Meng

Wang

et al. 2019

Front. Bioeng. Biotechnol.

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Multiple enzyme systems are being increasingly used for their high-efficiency and co-immobilization is a key technology to lower the cost and improve the stability of enzymes. In this study, poly glycidyl methacrylate (PGMA) spheres were synthesized using suspension polymerization, and were used as a support to co-immobilize glucose oxidase (GOx) and catalase (CAT). Surface modification was carried out via a combination of plasma and amination to promote the properties of the catalyzer. The co-immobilized enzymes showed a more extensive range of optimum pH and temperature from 5.5 to 7.5 and 25 to 40 • C, respectively, compared to free enzymes. Furthermore, the maximum activity and protein adsorption quantity of the co-immobilized enzymes reached 25.98 U/g and 6.07 mg/g, respectively. The enzymatic activity of the co-immobilized enzymes was maintained at ∼70% after storage for 5 days and at 82% after three consecutive cycles, indicating that the immobilized material could be applied industrially.

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Section: Optimization Of Immobilization Conditions and Characterizationsupporting

confidence: 90%

Coupling and Regulation of Porous Carriers Using Plasma and Amination to Improve the Catalytic Performance of Glucose Oxidase and Catalase

Liao

Meng

Wang

et al. 2019

Front. Bioeng. Biotechnol.

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“…Biological inertness and a lack of reactive functionality are among the poor properties of aliphatic polyesters. As a result, more and more research is devoted to their preparation for advanced materials for medical and regenerative applications to overcome the drawbacks arising from potential inflammatory side effects, including their high hydrophobicity, and low cell adhesion [9,10,11]. To eliminate such problems, current approaches include filling polyesters with nanoparticles of different nature [12,13] and their modification with other (macro)molecules of interest [14,15].…”

Section: Introductionmentioning

confidence: 99%

PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites

et al. 2019

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The development of biocompatible composite materials is in high demand in many fields such as biomedicine, bioengineering, and biotechnology. In this study, two series of poly (D,L-lactide) and poly (ε-caprolactone)-based films filled with neat and modified with poly (glutamic acid) (PGlu) nanocrystalline cellulose (NCC) were prepared. An analysis of scanning electron and atomic force microscopies’ results shows that the modification of NCC with poly (glutamic acid) favored the better distribution of the nanofiller in the polymer matrix. Investigating the ability of the developed materials to attract and retain calcium ions led to the conclusion that composites containing NCC modified with PGlu induced better mineralization from model solutions than composites containing neat NCC. Moreover, compared to unmodified NCC, functionalization with PGlu improved the mechanical properties of composite films. The subcutaneous implantation of these composite materials into the backs of rats and the further histological investigation of neighboring tissues revealed the better biocompatibility of polyester materials filled with NCC–PGlu.

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“…They have both hydrocarbon segments and ester parts in the main chain that allow many different processing method and chemical reactions. [9,30] To this end, in this article, the PCA fibers having polarity enhancing electron deficient internal alkyne units in the backbone were synthesized starting from ADCA and CHDM in the presence of PTSA, and sequential electrospinning process. Moreover, it was mainly investigated the relationship between the morphological, wetting, thermal and biodegradation properties of electrospun PCA fibers and the electrospinning parameters utilized.…”

Section: Resultsmentioning

confidence: 99%

Electrospinning of Poly(1,4‐Cyclohexanedimethylene Acetylene Dicarboxylate): Study on the Morphology, Wettability, Thermal and Biodegradation Behaviors

Dağlar

Altınkök

Açık

et al. 2020

Macro Chemistry & Physics

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production of environmentally friendly and biodegradable materials in academia and industry. [1] Three main classes of biodegradable polymers can be categorized in the literature: i) natural polymers such as polysaccharides, cellulose, starch and chitin or chitosan ii) synthetic polymers achieved after polymerization reactions such as polylactic acid (PLA) and poly(εcaprolactone) (PCL) or iii) blended form of both. [2] From the viewpoint of material development, thermoplastic linear aliphatic polyesters such as particularly PLAs, PCLs, polyglycolides (PGAs), poly(β-hydroxybutyrates) (PHBs) have a leading position and popularity in various areas ranging from biomedical to packaging industries due to their compostability, biocompatibility, degradability, eco-friendly and easy processability features. [3,4] Besides these attractive attributes, their good mechanical and thermal properties meet greatly the requirements of environmental, agricultural and surgical concerns. In addition, various functional groups on their hydrocarbon main chains can be easily modified for use in common chemical reactions and allow the material to be easily adapted to different processing methods. [5-9] Therefore, it is obvious that the production of innovative aliphatic polyesters with various functional groups and properties is of great importance for use in a wide variety of application areas. A variety of effective strategies have been used to generate the continuous fiber of natural, synthetic or blend polymers and inorganic materials origin including centrifugal or electro spinning, mechanical drawing, melt blowing, self-assembly, phase separation, template synthesis and freeze-drying for targeted applications. [10-13] However, unmanageable procedures, unsuitability for some polymers, non-adjustable fiber diameter and direction are among the disadvantages of most of these techniques. As a straightforward fiber fabrication method, electrospinning is adaptable to a variety of materials, and versatile technique for producing fibers with well-controlled surface topography, morphology and size distribution within a fiber diameter down to the nanometer by means of the electrostatic forces. [14] In this method, there are a number of process variables that need to be carefully optimized for the production This study is conducted to evaluate the biodegradation and thermal features of poly(1,4-cyclohexanedimethylene acetylene dicarboxylate) (PCA) based films and fibers. The PCA is characterized by Fourier transform infrared (FT-IR) and proton nuclear magnetic resonance (1 H-NMR) spectroscopies and gel permeation chromatography (GPC). The beadless fibers of PCA are achieved by electrospinning from its solution under ambient conditions for the first time. The effects of applied voltage and tip-to-collector distance (TCD) on the various properties such as morphology, wettability, thermal, and biodegradability behaviors of fibers are investigated by comparing the non-electrospun PCA. Morphologies and average frequency distributions of the electro...

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Surface Modification of Aliphatic Polyester to Enhance Biocompatibility

Cited by 58 publications

References 69 publications

Coupling and Regulation of Porous Carriers Using Plasma and Amination to Improve the Catalytic Performance of Glucose Oxidase and Catalase

Coupling and Regulation of Porous Carriers Using Plasma and Amination to Improve the Catalytic Performance of Glucose Oxidase and Catalase

PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites

Electrospinning of Poly(1,4‐Cyclohexanedimethylene Acetylene Dicarboxylate): Study on the Morphology, Wettability, Thermal and Biodegradation Behaviors

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