Surface modification of biodegradable AZ91 magnesium alloy by electrospun polymer nanocomposite: Evaluation of in vitro degradation and cytocompatibility

Panahi, Zahra; Tamjid, Elnaz; Rezaei, Masoud

doi:10.1016/j.surfcoat.2020.125461

Cited by 35 publications

(23 citation statements)

References 56 publications

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“…The advantage of using ZIF-8 is ascribed to its anti-corrosion properties 60 , 61 that can reduce the electrochemical potential and current density of AZ91 alloy 24 , 62 as well as its high stability in physiological environment and drug loading capacity 24 – 28 . Although our coating materials seem to be less protective as compared to bioinert and dense protective layers 23 , 63 – 65 , employing fibrous membranes provide a better platform for cell adhesion and bone integration.…”

Section: Discussionmentioning

confidence: 97%

“…Studies of Tiyyagura et al 10 indicated that along with the reduced corrosion rate, the chitosan film promoted the formation of the hydroxyapatite layer on the surface. Panahi et al 23 employed electrospinning to prepare polycaprolactone-bioactive glass (BG) fibrous composite coatings on AZ91 alloy. Detailed electrochemical studies have determined that the composite coating significantly decreases the corrosion current through retarding ion and electron transport between the surface and the liquid environment.…”

Section: Introductionmentioning

confidence: 99%

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Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings

Khalili

Tamjid

2021

Sci Rep

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Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a metal–organic framework (MOF) nanoplates to reduce the degradation rate of AZ91 magnesium alloy. Zeolitic imidazolate frameworks (ZIF-8) with a specific surface area of 1789 m2 g−1 were prepared by solvothermal methods, and after dispersion in a chitosan solution (10% w/w), the suspension was electrospun on the surface of AZ91 alloy. Studying the degradation rate in simulated body fluid (SBF) by electrochemical analysis including potentiodynamic polarization and electrochemical impedance spectroscopy reveals that the degradation rate of the surface-modified implants decreases by ~ 80% as compared with the unmodified specimens. The reduced alkalization of the physiological environment and hydrogen release due to the implant degradation are shown. In vitro studies by fibroblasts and MG63 osteosarcoma cells exhibit improved cell adhesion and viability. The mechanisms behind the improved degradation resistance and enhanced bioactivity are presented and discussed. Surface modification of MBIs by MOF-chitosan coatings is a promising strategy to control the biodegradation of magnesium implants for bone regeneration.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings

Khalili

Tamjid

2021

Sci Rep

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“…In addition to orthopedic applications in the form of pins, screws, rods and plates, Mg alloys have been investigated in cardiovascular applications as biodegradable Mg alloy stents [6][7][8][9][10][11] due to their biodegradability and mechanical properties. In addition, the ideal cardiovascular stent biomaterial should promote endothelialization with minimal neo-intimal hyperplasia.…”

Section: Introductionmentioning

confidence: 99%

Microstructural, Electrochemical and In Vitro Analysis of Mg-0.5Ca-xGd Biodegradable Alloys

et al. 2021

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The subject of Mg-based biodegradable materials, used for medical applications, has been extensively studied throughout the years. It is a known fact that alloying Mg with biocompatible and non-toxic elements improves the biodegradability of the alloys that are being used in the field of surgical applications. The aim of this research is to investigate the aspects concerning the microstructure, electrochemical response (corrosion resistance) and in vitro cytocompatibility of a new experimental Mg-based biodegradable alloy—Mg–0.5%Ca with controlled addition of Gd as follows: 0.5, 1.0, 1.5, 2.0 and 3.0 wt.%—in order to establish improved biocompatibility with the human hard and soft tissues at a stable biodegradable rate. For this purpose, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), light microscopy (LM) and X-ray diffraction (XRD) were used for determining the microstructure and chemical composition of the studied alloy and the linear polarization resistance (LPR) method was used to calculate the corrosion rate for the biodegradability rate assessment. The cellular response was evaluated using the 3-(4,5-dimethyltiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test followed by fluorescence microscopy observation. The research led to the discovery of a dendritic α-Mg solid solution, as well as a lamellar Mg2Ca and a Mg5Gd intermetallic compound. The in vivo tests revealed 73–80% viability of the cells registered at 3 days and between 77 and 100% for 5 days, a fact that leads us to believe that the experimental studied alloys do not have a cytotoxic character and are suitable for medical applications.

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“…Commercial Mg alloys, including WE (Mg-RE-Zr) series (WE43, WE54), AZ (Mg-Al-Zn) series (AZ31, AZ91) and gravity-cast LAE442, were considered along with pure Mg as the suitable materials that not only have a significantly lower density, but also have mechanical strength ensuring sufficient radial resistance compared with other metallic stenting materials such as 316L stainless steel. More importantly, Mg alloys possess good biocompatibility and an adequate degradation property for stent applications [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Evaluating magnesium alloy WE43 for bioresorbable coronary stent applications

et al. 2021

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Biodegradable stents, especially those composed of magnesium alloy-based materials, can provide a temporary scaffold that support vessels while naturally resorbing in the body after the targeted vessel heals, thereby preventing the restenosis and late thrombosis issues caused by their metallic predecessors. However, due to limitations in the intrinsic mechanical properties of magnesium, further investigation is required to optimize its degradation property, as well as the design, geometry and strut thickness to improve conformability in stent applications. This study aimed to investigate experimentally the degradation property of magnesium alloy WE43 and to optimize the stent geometry through parametric studies using the finite element method. Results of the degradation testing showed that the WE43 with a secondary polycaprolactone dip-coating offered a greater resistance to biodegradation and increased the lifespan of the stent. On average, the resistance to biodegradation increased by 5% in the WE43 magnesium alloy compared with its counterpart lacking any surface coating. The parametric studies have indicated that the stent with honeycomb geometry and a radial thickness of 0.15 mm had demonstrated promising mechanical performance with minimal dog-boning, foreshortening and recoil.

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Surface modification of biodegradable AZ91 magnesium alloy by electrospun polymer nanocomposite: Evaluation of in vitro degradation and cytocompatibility

Cited by 35 publications

References 56 publications

Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings

Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings

Microstructural, Electrochemical and In Vitro Analysis of Mg-0.5Ca-xGd Biodegradable Alloys

Evaluating magnesium alloy WE43 for bioresorbable coronary stent applications

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