Surface modification of cobalt–chromium–tungsten–nickel alloy using octadecyltrichlorosilanes

Mani, Gopinath; Feldman, Marc D.; Oh, Se Baek; Agrawal, C. Mauli

doi:10.1016/j.apsusc.2009.01.046

Cited by 51 publications

(51 citation statements)

References 79 publications

(128 reference statements)

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“…The XPS indicated significant differences in the surface chemistry between electropolished CoCr and previously reported mechanically polished CoCr. 23 After mechanical polishing CoCr and with similarly cleaning procedures, Mani et al 23 reported the following XPS determined elemental atomic concentrations: O: 52.7% 6 1.5%, Co: 6.2% 6 0.6 %, Cr 1.9% 6 0.7%, Ni: 1.1% 6 0.03%, W: 0.7% 6 0.2%. Compared to the mechanically polished CoCr surface chemistry, electropolishing CoCr significantly decreases the Cobalt and Nickel atomic concentrations (1.9% 6 0.1% and 0.4% 6 0.04%, respectively) and increases the atomic concentrations of Oxygen, Chromium, and Tungsten (63.3% 6 0.2%, 7.0% 6 0.2%, and 2.5% 6 0.1%, respectively).…”

Section: Electropolished Cocrmentioning

confidence: 99%

“…[16][17][18][19][20][21][22][23] However, electropolished (EP) metals such as 316L stainless steel (SS) or L605 cobalt chromium alloy (CoCr) have different surface chemistry than that of the native or mechanically polished surfaces. Several studies report increased concentrations of oxygen and metallic elements compared to the as-received metal surface, specifically increased chromium and hydroxyl group concentrations and decreased iron concentration.…”

Section: Introductionmentioning

confidence: 99%

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Long‐term stability of self‐assembled monolayers on electropolished L605 cobalt chromium alloy for stent applications

et al. 2011

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Commercially available drug-eluting stents have the potential to induce inflammatory and hypersensitive adverse reactions due to their polymer coating. The use of self assembled monolayers (SAMs) as an alternate drug delivery platform for stents has recently been demonstrated. In this study, the formation and stability of phosphonic acid SAMs were investigated using the material and surface preparation commonly used to make ultra-thin stent struts-electropolished L605 Cobalt Chromium (CoCr) alloy. Methyl (⁻CH₃) and carboxylic acid (⁻OOH) terminated phosphonic acid SAMs were coated on electropolished CoCr alloy using a combination of solution immersion and dip-evaporation cycle deposition methods. SAMs-coated CoCr alloy specimens were thoroughly characterized using contact angle goniometry, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). These characterizations suggested that uniform and well-ordered monolayers were coated on the electropolished CoCr alloy. The long-term physiological stability of monolayers was investigated in tris-buffered saline (TBS) at 37°C for up to 28 days. Contact angles, FTIR, XPS, and AFM suggested that both ⁻CH₃ and ⁻COOH terminated phosphonic acid SAMs desorb from electropolished CoCr alloy surfaces in a biphasic manner. A significant desorption of ⁻CH₃ and ⁻COOH terminated SAMs occurs within 1-3 days followed by a slower desorption for up to 28 days. Thus, there is a need to develop techniques that can improve the long-term stability of SAMs on electropolished CoCr alloy for stent and other biomedical applications.

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Section: Electropolished Cocrmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long‐term stability of self‐assembled monolayers on electropolished L605 cobalt chromium alloy for stent applications

et al. 2011

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“…Several studies have showed the presence of such hydrocarbon contaminant species on different metal oxides. [31][32][33][34] Also, the C u C peak of hydrocarbon contamination at 285 eV has been commonly used as an internal standard for XPS calibration. 34 The C 1s spectrum of SAM-Cou Cr alloy was deconvoluted into three components as well.…”

Section: Xps Characterizationmentioning

confidence: 99%

“…33,[37][38][39][40] Typically, for a well-ordered monolayer, the peaks of asym ͑CH 2 ͒ and sym ͑CH 2 ͒ have been observed at Ͻ2918 and Ͻ2850 cm −1 , respectively. 33,37,38 In our study, the peaks of asym ͑CH 2 ͒ and sym ͑CH 2 ͒ were observed at 2917 and 2849 cm −1 , respectively ͓Fig. 2͑a͔͒.…”

Section: Ftir Characterizationmentioning

confidence: 99%

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Mani

Torres

2011

Biointerphases

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Polymer-based platforms in drug-eluting stents ͑DESs͒ can cause adverse reactions in patients. Hence, the development of a polymer-free drug delivery platform may reduce adverse reactions to DES. In this study, the use of a polymer-free platform, self-assembled monolayers ͑SAMs͒, is explored for delivering an antiproliferative drug ͓paclitaxel ͑PAT͔͒ from a stent material ͓cobalt-chromium ͑͑Cou Cr͒ alloy͔. Initially, carboxylic acid terminated phosphonic acid SAMs were coated on Cou Cr alloy. Two different doses ͑25 and 100 g / cm 2 ͒ of PAT were coated on SAM coated Cou Cr surfaces using a microdrop deposition method. Also, control experiments were carried out to coat PAT directly on Cou Cr surfaces with no SAM modification. The PAT coated specimens were characterized using the Fourier transform infrared spectroscopy ͑FTIR͒, scanning electron microscopy ͑SEM͒, and atomic force microscopy ͑AFM͒. FTIR spectra showed the successful deposition of PAT on SAM coated and control-Cou Cr surfaces. SEM images showed islands of high density PAT crystals on SAM coated surfaces, while low density PAT crystals were observed on control-Cou Cr alloy. AFM images showed molecular distribution of PAT on SAM coated as well as control-Cou Cr alloy surfaces. In vitro drug release studies showed that PAT was released from SAM coated Cou Cr surfaces in a biphasic manner ͑an initial burst release in first 7 days was followed by a slow release for up to 35 days͒, while the PAT was burst released from control-Cou Cr surfaces within 1-3 days. Thus, this study demonstrated the use of SAMs for delivering PAT from Cou Cr alloy surfaces for potential use in drug-eluting stents.

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“…This increase is indicative of the presence of the organosilane on the surface metal and suggests that the silanization process performance was higher for APTES than for CPTES. It is important to underline that for both silanized surface (APTES and CPTES) appeared a new component corresponding to siloxane bond OSi-O at 103.3 eV [47,48], thus demonstrating that silane molecules were chemically bound to alloy surface via residual ethoxy groups on the metal substrate and not physiosorbed. The contribution at 102.3 eV can be assigned to some contamination due to polishing process by silica colloidal [57].…”

Section: Si 2p Spectramentioning

confidence: 99%

Study on the use of 3‐aminopropyltriethoxysilane and 3‐chloropropyltriethoxysilane to surface biochemical modification of a novel low elastic modulus Ti–Nb–Hf alloy

et al. 2014

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A biocompatible new titanium alloy Ti–16Hf–25Nb with low elastic modulus (45 GPa) and the use of short bioadhesive peptides derived from the extracellular matrix have been studied. In terms of cell adhesion, a comparative study with mixtures of short peptides as RGD (Arg‐Gly‐Asp)/PHSRN (Pro‐His‐Ser‐Arg‐Asn) and RGD (Arg‐Gly‐Asp)/FHRRIKA (Phe‐His‐Arg‐Arg‐Ile‐Lys‐Ala) have been carried out with rat mesenchymal cells. The effect of these mixtures of short peptides have already been studied but there are no comparative studies between them. Despite the wide variety of silane precursors available for surface modification in pure titanium, the majority of studies have used aminosilanes, in particular 3‐minopropyltriethoxysilane (APTES). Nevertheless, the 3‐chloropropyltriethoxysilane (CPTES) is, recently, proposed by other authors. Unlike APTES, CPTES does not require an activation step and offers the potential to directly bind the nucleophilic groups present on the biomolecule (e.g., amines or thiols). Since the chemical surface composition of this new alloy could be different to that pure titanium, both organosilanes have been compared and characterized by means of a complete surface characterization using contact angle goniometry and X‐ray photoelectron spectroscopy. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B:495–502, 2015.

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Surface modification of cobalt–chromium–tungsten–nickel alloy using octadecyltrichlorosilanes

Cited by 51 publications

References 79 publications

Long‐term stability of self‐assembled monolayers on electropolished L605 cobalt chromium alloy for stent applications

Long‐term stability of self‐assembled monolayers on electropolished L605 cobalt chromium alloy for stent applications

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Study on the use of 3‐aminopropyltriethoxysilane and 3‐chloropropyltriethoxysilane to surface biochemical modification of a novel low elastic modulus Ti–Nb–Hf alloy

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