Surface modification of graphene sheets with aluminum phthalocyanine complex

Клименко, И. В.; Trusova, E. A.; Щеголихин, А. Н.; Jurina, Lubov V.

doi:10.1080/1536383x.2021.1976754

Cited by 2 publications

(2 citation statements)

References 39 publications

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“… 441 Klimenko et al also showed that graphene prevents the agglomeration of the aluminum phthalocyanine chloride (AlClPc). 442 …”

Section: Recent Approaches Future Of Pdt and Conclusionmentioning

confidence: 99%

“…441 Klimenko et al also showed that graphene prevents the agglomeration of the aluminum phthalocyanine chloride (AlClPc). 442 The application of graphene-based PDT holds promise in advancing personalized medicine methods. By using the unique properties of graphene nanomaterials, patient-specific treatment approaches can be developed to overcome specific resistance mechanisms.…”

Section: Dovepressmentioning

confidence: 99%

See 1 more Smart Citation

Graphene-Based Photodynamic Therapy and Overcoming Cancer Resistance Mechanisms: A Comprehensive Review

Dilenko,

Bartoň Tománková,

Válková

et al. 2024

IJN

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“… 441 Klimenko et al also showed that graphene prevents the agglomeration of the aluminum phthalocyanine chloride (AlClPc). 442 …”

Section: Recent Approaches Future Of Pdt and Conclusionmentioning

confidence: 99%

Section: Dovepressmentioning

confidence: 99%

Graphene-Based Photodynamic Therapy and Overcoming Cancer Resistance Mechanisms: A Comprehensive Review

Dilenko,

Bartoň Tománková,

Válková

et al. 2024

IJN

View full text Add to dashboard Cite

Dimerization of Aluminum Phthalocyanine Chloride in Organic and Aqua-Organic Medium

Клименко

Astakhova²,

Timokhina³

et al. 2022

Russian Journal of Biological Physics and Chemisrty

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Aluminum phthalocyanine chloride (AlClPc) is a photoactive macroheterocyclic compound, which, in its monomeric form, is used as a photosensitizer (PS) in photodynamic therapy and diagnostics. In this paper, its physicochemical properties were studied in organic (N, N-dimethylformamide, DMF) and aqua-organic (DMF-aqua) media. It has been shown that the hydrophobic properties of AlClPc prevent its widespread use in various pharmacological compositions due to its tendency to aggregate in aqueous solutions, which leads to the formation of non-fluorescent aggregates and a decrease in its photodynamic activity. The geometry and electronic structure of AlClPc in the monomeric and dimerized (H- and J-aggregates) states were studied using quantum-chemical calculations with the help of the electron density functional theory (DFT) method. Different types of orientation during the dimerization of AlClPc molecules are presented: “back to back”, “head to head”, “head to back”, as well as mixed-oriented types. It has been proven that both in DMF and DMF-aqua media, the preferred orientation is “back to back”, without sacrificing the monomeric geometry of the constituent molecules in the dimer. It is shown that in an aqueous organic solvent the AlClPc molecule is easily hydrated with the formation of a coordination bond between the Al atom of the AlClPc molecule and the O atom of the aqua molecule. The bond length is 2.23 Å, and the hydration energy is 16.84 kcal/mol. Hydration promotes the formation of dimers, in which two aqua molecules play the role of "bridges" between two AlClPc molecules. In such dimer, each aqua molecule has two bonds: one coordination bond between its O atom and the Al atom of one of the AlClPc molecules and one hydrogen bond between its H atom and the N atom of another AlClPc molecule. Based on the calculated data obtained, the AlClPc dimers in the DMF medium were assigned to H-aggregates, and in the DMF-water medium, to J-aggregates, respectively.

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Surface modification of graphene sheets with aluminum phthalocyanine complex

Cited by 2 publications

References 39 publications

Graphene-Based Photodynamic Therapy and Overcoming Cancer Resistance Mechanisms: A Comprehensive Review

Graphene-Based Photodynamic Therapy and Overcoming Cancer Resistance Mechanisms: A Comprehensive Review

Dimerization of Aluminum Phthalocyanine Chloride in Organic and Aqua-Organic Medium

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