Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

Priya, Sakshi; Desai, Vaibhavi Meghraj; Singhvi, Gautam

doi:10.1021/acsomega.2c05976

Cited by 70 publications

(25 citation statements)

References 88 publications

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“…Polymers like poly(ethylene glycol) (PEG), PCL, chitosan, and PEG-based surfactants like polysorbate 80 and poloxamer 188 can be chemically grafted or adsorbed on the surface of PLGA NPs and SLNs. The hydrophilicity of these moieties increases steric hindrance and circulation time while prohibiting uptake by the reticuloendothelial system (RES) [ 36 ]. PEGylation of NPs for CNS drug delivery is common and is reported to improve the circulation time, biocompatibility, and brain uptake, even in pathological conditions [ 9 , 10 , 37 , 38 ].…”

Section: Nanotechnology For Bbb Crossingmentioning

confidence: 99%

“…CNS specific targeting can be achieved using ligands with high affinity for receptors and transporters expressed on the surface of BBB endothelial cells. These ligands include transferrin, lactoferrin, apolipoprotein E, glucose derivatives, and glutathione, which facilitate the brain uptake of NPs through receptor-mediated transcytosis and carrier-mediated transport mechanisms [ 36 ]. Cell-penetrating peptides (CPPs) like the transactivator of transcription can also be bound to the surface of NPs through covalent or non-covalent interactions [ 8 ].…”

Section: Nanotechnology For Bbb Crossingmentioning

confidence: 99%

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Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery

et al. 2023

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Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases. Polymer and lipid-based drug carriers are advantageous for delivery to the central nervous system (CNS) due to their safety profiles, drug-loading capacity, and controlled-release properties. Polymer and lipid-based nanoparticles (NPs) are reported to penetrate the blood–brain barrier (BBB) and have been extensively assessed in in vitro and animal models of glioblastoma, epilepsy, and neurodegenerative disease. Since approval by the Food and Drug Administration (FDA) of intranasal esketamine for treatment of major depressive disorder, intranasal administration has emerged as an attractive route to bypass the BBB for drug delivery to the CNS. NPs can be specifically designed for intranasal administration by tailoring their size and coating with mucoadhesive agents or other moieties that promote transport across the nasal mucosa. In this review, unique characteristics of polymeric and lipid-based nanocarriers desirable for drug delivery to the brain are explored in addition to their potential for drug repurposing for the treatment of CNS disorders. Progress in intranasal drug delivery using polymeric and lipid-based nanostructures for the development of treatments of various neurological diseases are also described.

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Section: Nanotechnology For Bbb Crossingmentioning

confidence: 99%

Section: Nanotechnology For Bbb Crossingmentioning

confidence: 99%

Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery

et al. 2023

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“…During formation, liposomes acquire structural characteristics (number of layers) and various sizes [27,28,29]. Based on their size and number of bilayers, liposomes can be classified in two main categories: unilamellar vesicles and multilamellar vesicles (Table 2).…”

Section: Formation and Classification Of Liposomesmentioning

confidence: 99%

Current Applications of Liposomes for the Delivery of Bioactives: A Review on the Encapsulation of Vitamins

Chaves¹,

Ferreira²,

Baldino³

et al. 2023

Preprint

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Liposomes have been used for several decades for the encapsulation of drugs and bioactives in cosmetics and cosmeceuticals. On the other hand, the use of these phospholipid vesicles in food applications is more recent and has been increasing significantly in the last ten years. Although in different stages of technological maturity - in the case of cosmetics, many products are on the market - processes to obtain liposomes suitable for the encapsulation and delivery of bioactives are highly expensive, especially aiming at scaling-up. Among the bioactives proposed for cosmetics and food applications, vitamins are the most frequently used. Despite the differences between the administration routes (oral for food and mainly dermal for cosmetics), some challenges are very similar (e.g., stability, bioactive load, average size, increase of drug bioaccessibility and bioavailability). In the present work, a systematic review of the technological advancements in the nanoencapsulation of vitamins using liposomes and related processes was performed; challenges and future perspectives were also discussed in order to underline the advantages of these drug loaded biocompatible nanocarriers for cosmetics and food applications.

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“…Polymeric NPs (PNPs) are submicron colloidal particles broadly used in drug delivery systems, owing to the relatively easy attachment of targeting ligands to the surface of NPs. Surface modification of these PNPs with targeting ligands enables recognition by specific receptors or ligand-binding sites that are overexpressed on cancer cells or at target sites, for the controlled release of loaded drugs [ 25 , 26 , 27 , 28 ]. The rational design of targeted drug delivery systems based on PNPs involves taking into consideration their composition, solubility, crystallinity, molecular weight, backbone stability, hydrophobicity and polydispersity.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

et al. 2023

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Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity between cells within the tumor. Revolutionary drug delivery is expected to provide a solution to that challenge. Chitosan nanoparticles (CSNPs) have prospects as a revolutionary delivery system capable of enhancing anticancer drug activity and reducing negative impacts on normal cells. The use of smart drug delivery systems (SDDs) as delivering materials to improve the bioactivity of NPs and to understand the intricacies of breast cancer has garnered significant interest. There are many reviews about CSNPs that present various points of view, but they have not yet described a series in cancer therapy from cell uptake to cell death. With this description, we will provide a more complete picture for designing preparations for SDDs. This review describes CSNPs as SDDSs, enhancing cancer therapy targeting and stimulus response using their anticancer mechanism. Multimodal chitosan SDDs as targeting and stimulus response medication delivery will improve therapeutic results.

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Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

Cited by 70 publications

References 88 publications

Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery

Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery

Current Applications of Liposomes for the Delivery of Bioactives: A Review on the Encapsulation of Vitamins

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

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