Surface Modification of Poly(dimethylsiloxane) with Polydopamine and Hyaluronic Acid To Enhance Hemocompatibility for Potential Applications in Medical Implants or Devices

Abstract

Poly(dimethylsiloxane) (PDMS) has been widely utilized in micro-electromechanical systems (MEMS) and implantable devices. To improve the hemocompatibility of a PDMS-based implant, a facile technique was developed by modifying PDMS with a hyaluronic acid (HA) and polydopamine (PDA) composite (HA/PDA). Under appropriate ratio of HA to PDA, platelet adhesion and activation were considerably reduced on modified PDMS substrates, indicating an enhanced hemocompatibility compared to native PDMS or those coated with HA or PDA solely. HA/PDA coating also posed minimal cytotoxicity on the adhesion and proliferation of endothelial cells (HUVECs). The anti-inflammation effect of the modified PDMS surface was characterized based on the expression of critical cytokines in adherent macrophages. This study revealed that the hemocompatibility, cytotoxicity, and anti-inflammation properties could be tailored conveniently by adjusting the ratio of HA and PDA composite on the modified PDMS surface, which has an exceptional potential as the core or packaging material for constructing implantable devices in biomedical applications.

Biopolymer Coatings for Biomedical Applications

“…These advantages can be useful for the development of medical implants and devices. PDMS with enhanced hemocompatibility was developed for medical implant or device application by modifying the surface using a PDA and hyaluronic acid (HA/PDA) composite [67], as shown in Figure 7. Enhanced hemocompatibility was observed for a particular HA/PDA composition, using which platelet adhesion and activation were reduced, compared to that observed in other combinations of PDMS and HA or PDA coatings.…”

Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture

“…Alternatively, mussel-inspired polydopamine (PD) can virtually form a coating on all types of materials including metals, semiconductors, ceramics and synthetic polymers by covalent bonding or non-covalent strong interfacial interactions such as hydrogen bonds, π-π electron interaction and cation- π interactions [ 20 , 21 ]. PD coating has also been applied on PDMS substrates for conjugating biomolecules to upgrade its performance for cell adhesion and other applications [ [22] , [23] , [24] ]. The strong adhesive nature of polydopamine is attributed to the presence of biomimetic catechol and primary amines that are found in the chemical structure of the native mussel adhesive proteins [ 20 ].…”

Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability

“…Numerous strategies have been developed to improve cells adhesion and proliferation performance, resulting in endothelialization in vitro and in vivo. 12,[14][15][16][17][18][19][20][21][22][23][24][25][26] Shin 27 et al enhanced the endothelialization of poly(L-lactide-co-ε-caprolactone) vascular grafts through polydopamine coating and the immobilization of vascular endothelial growth factors. Inseong 28 et al utilized PDA as an adaptor to graft heparin onto polyurethane substrates, leading to the enhancement of blood compatibility.…”

“…Numerous strategies have been developed to improve cells adhesion and proliferation performance, resulting in endothelialization in vitro and in vivo . Shin et al enhanced the endothelialization of poly( l ‐lactide‐ co ‐ε‐caprolactone) vascular grafts through polydopamine coating and the immobilization of vascular endothelial growth factors.…”