Surface modification of polysulfone ultrafiltration membranes and fouling by BSA solutions

Nabe, Anke; Staude, Eberhard; Belfort, Georges

doi:10.1016/s0376-7388(97)00073-2

Cited by 274 publications

(99 citation statements)

References 23 publications

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“…Although the parent or unmodi®ed membrane was the smoothest, the fouling and cleaning indexes used below as a measure of performance were always worse for the PSU membrane than that for the rougher but more hydrophilic PSU-COOH and SPSU membranes. This situation has been reported before [16] and underlines the importance of surface chemistry as the fouling-determining factor when ultra®l-tering a protein solution.…”

Section: Afm-measurementssupporting

confidence: 74%

“…Here several layers of proteinaceous deposit are built up and each new layer comes in contact with a protein surface rather than a virgin polymeric membrane surface. This has been observed by Nabe et al [16] before when working with polysulfone membranes that had been chemically modi®ed and challenged with BSA in an ultra®ltration experiment. Either the chemistry of the surface (intermolecular forces) extends its effect through the surfaceassociated protein into the solution or the surface in not fully covered and took time to be so.…”

Section: Fouling Experimentssupporting

confidence: 58%

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Static protein adsorption, ultrafiltration behavior and cleanability of hydrophilized polysulfone membranes

Möckel

Staude

Guiver

1999

Journal of Membrane Science

167

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A systematic study on the in¯uence of incrementally increased hydrophilicity of UF membranes made from chemically modi®ed polysulfone on static protein adsorption, protein ultra®ltration performance and cleanability was performed. Hydrophilicity was imparted to the polymeric backbone either by carboxylation or sulfonation. Membranes with 100% retention towards sulfhydryl modi®ed bovine serum albumin (cys-BSA) were made by the phase inversion process from unmodi®ed polysulfone, ®ve carboxylated polysulfones (degrees of carboxylation ranging from 0.26 to 1.74) and two sulfonated polysulfones (degrees of sulfonation of 0.24 and 0.58). 1000 ppm aqueous solutions of cys-BSA at pH values 3, 4.8 and 9 were used in KCl medium at either low or high concentration. Static adsorption, ultra®ltration (UF)¯ux reduction and protein binding strength were lower at pH 3 than at pH 9 but reached an expected maximum at the protein's isoelectric point at pH 4.8. Hydrophilized polysulfone membranes show less static adsorption and lower UF¯ux reduction than hydrophobic unmodi®ed membranes. In all experiments we found that the higher the degree of carboxylation or sulfonation, the greater this effect. High ionic strengths reduced these advantages at pH values above or below the IEP but had a positive effect at the IEP. #

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Section: Afm-measurementssupporting

confidence: 74%

Section: Fouling Experimentssupporting

confidence: 58%

Static protein adsorption, ultrafiltration behavior and cleanability of hydrophilized polysulfone membranes

Möckel

Staude

Guiver

1999

Journal of Membrane Science

167

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“…Membranes were prepared by (i) substitution with functionalized groups, (ii) by polymer graft modification or (iii) by surface modification of prefabricated membranes [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Study of Polysulfone and Polyacrylic Acid (PSF/PAA) Membranes Morphology by Kinetic Method and Scanning Electronic Microscopy

Mbareck¹

2015

J Membra Sci Technol

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Experiment Polymer propertiesPolysulfone (PSf) and poly (acrylic acid) (PAA) were supplied by Aldrich and dimethyl formamide (DMF) by Prolabo. All polymers and chemical products were used as supplied, without any further purification. Molecular weights of PAA and PSf were 450 000 and 26 000 g/mol, respectively. Membrane preparationPolysulfone (PSf) and Poly (acrylic acid) (PAA) were dissolved, separately, in dimethyl formamide (DMF) in a glass reactor equipped with a mechanical stirrer and thermostated at 90°C for over 3 hours. The PSf concentration was 17 (or 19) wt. % and that of PAA was 5 wt. %. Afterwards, both solutions were mixed together in known proportions, stirred for 30 min and de-bubbled. Such de-bubbled casting-solution was casted on a glass plate with a lab-made Gardner knife, dried in freeair for a known time (generally 20 seconds) and finally immersed in a coagulation-bath containing a sufficient volume of MilliQ water (18.2 MΩcm) at 18°C. Membranes were thoroughly washed with water, and stored in a dilute sodium azide solution till their use. Kinetic measurementFive polymer-solutions with the same mass (2 g) and different composition (PSf/PAA 100/0, 96/04, 92/08, 89/11 and 83/17) were poured on a glass plate to get exactly a same surface area. Afterwards, AbstractThis work focuses on the study of the morphology forming of Polysulfone (PSf) and polyacrylic acid (PAA) membranes which are prepared by mixing both of the polymers in DMF and the obtained blend is precipitated in water (non-solvent). The precipitation kinetic and the effects of polysulfone concentration, drying-time in free-air and proportions of both polymers are investigated.Based on the SEM technique, the kinetic and viscosity measurements, and the visual observations, this study brings to the fore the different steps of the morphology forming of PSf/PAA membranes: formation of finger-like structures, sponge-like-structures, inner pores, superficial pores and the craters. Appearance of these structures is governed by the exchange process, between casting polymer-solution and the precipitation-bath (coagulation), which is controlled by operating conditions. This work constitutes a great tool in understanding the mechanisms of the morphology forming of PSf/PAA membranes and to improve their performances: preparation of tailored membrane.

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“…Several trials have been carried out for such purposes: sensors such as humidity sensors [9], carbon monoxide sensors [10], drug sensors [11], carriers for enzymes [12], solid polyelectrolytes [13] and carriers for functional materials [14]. PVP (polyvinylpyrrolidone, povidone, polyvidone) is made from the monomer N-vinyl pyrrolidone, PVP is soluble in water and other polar solvents.…”

Section: Introductionmentioning

confidence: 99%

Effect of PVP content on the quaternized polysulfone in blend membranes

Huang

Xiao

2010

E-Polymers

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A series of blend membranes of quaternized polysulfone (QPSF) and polyvinylpyrrolidone (PVP) were obtained by a novel method. The procedure of quaternization of chloromethylated polysulfone and the process of blend are synchronous. These blend membranes, prepared with quaternized polysulfone (QPSF) and polyvinylpyrrolidone (PVP), were characterized by FTIR, X-ray diffraction (XRD), tensile tests and scanning electron microscopy (SEM). The degrees of swelling of the membranes in some solvent were also measured. The ionic resistances of the membranes were measured too. With the increasing of PVP content, the properties of the membranes have changed. The tensile strength of blend membrane dropped while the degrees of swelling of the membranes in water increased. The ionic resistance of the membrane dropped with the PVP content increasing in blend membranes. The polyvinylpyrrolidone (PVP) has good compatibility with quaternized polysulfone in blend membranes.

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Surface modification of polysulfone ultrafiltration membranes and fouling by BSA solutions

Cited by 274 publications

References 23 publications

Static protein adsorption, ultrafiltration behavior and cleanability of hydrophilized polysulfone membranes

Static protein adsorption, ultrafiltration behavior and cleanability of hydrophilized polysulfone membranes

Study of Polysulfone and Polyacrylic Acid (PSF/PAA) Membranes Morphology by Kinetic Method and Scanning Electronic Microscopy

Effect of PVP content on the quaternized polysulfone in blend membranes

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