Surface modification of polyurethane and silicone for therapeutic medical technics by means of electron beam

Wetzel, C.; Schönfelder, Jessy; Schwarz, W.; Funk, Richard

doi:10.1016/j.surfcoat.2010.07.103

Cited by 21 publications

(15 citation statements)

References 17 publications

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“…The weight loss at this stage could be resulted from the decomposition of urethane/urea bonds in polyurethane materials since PMPS‐NH lost only about 10% weight at this temperature range. Moreover, introduction of silicone and higher crosslinking densities resulting from the SiOSi crosslinking network after moisture curing were responsible to the higher thermal stability of SPUs which was consistent with the literature …”

Section: Resultssupporting

confidence: 90%

Synthesis and characterization of phenyl polysiloxane modified polyurea/polyurethanes

Xie

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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A series of phenyl polysiloxane-modified polyurea/ polyurethanes (SPUs) with different silicone loadings (10,20,30, and 40 wt %) have been designed and synthesized. The structures of SPUs were confirmed by 1 H NMR, 13C NMR, and FT-IR. The impact of phenyl polysiloxane content on the properties of SPUs was fully studied. The residual methoxy groups on silicon could help SPUs form interpenetrating networks accompanying with the residual isocyanate under moisture, which was different with the conventional moisturecrosslinking polyurethane system. The properties of SPUs films have been fully researched by attenuated total reflection flourier transformed infrared spectroscopy, thermal analysis, tensile tests, water contact angle, X-ray photoelectron spectroscopy, SEM, and AFM. Results indicated that the introduction of phenyl polysiloxane improved the thermal stability and remarkably increased the water contact angles accompanying with a comparable mechanical strength to the pure polyurethane. Meanwhile, it also brought out the decreased microphase separation and water absorption. The obvious surface migration has been observed in the SPUs, which changed their surface properties. Some voids were observed in all moisture curing SPUs system, but the phenyl silicone content impacted on the numbers and sizes of the voids. The phenyl groups introduced and carbon dioxide produced in the crosslinking procedure helped to form and stabilize the voids in the SPUs.

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Section: Resultssupporting

confidence: 90%

Synthesis and characterization of phenyl polysiloxane modified polyurea/polyurethanes

Xie

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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“…In contrast, low energy electron irradiation (LEEI, <500 keV), does not require complex shielding because the amount of X-rays generated is much lower. Until now, LEEI has mainly been used for sterilizing surfaces [14,15], since it is less penetrating than high energy electrons. As a consequence, liquid solutions must be present as thin liquid films (>1 mm) in order to be completely irradiated by LEEI.…”

Section: Introductionmentioning

confidence: 99%

Pathogens Inactivated by Low-Energy-Electron Irradiation Maintain Antigenic Properties and Induce Protective Immune Responses

Fertey

Bayer

Grünwald

et al. 2016

Viruses

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Inactivated vaccines are commonly produced by incubating pathogens with chemicals such as formaldehyde or β-propiolactone. This is a time-consuming process, the inactivation efficiency displays high variability and extensive downstream procedures are often required. Moreover, application of chemicals alters the antigenic components of the viruses or bacteria, resulting in reduced antibody specificity and therefore stimulation of a less effective immune response. An alternative method for inactivation of pathogens is ionizing radiation. It acts very fast and predominantly damages nucleic acids, conserving most of the antigenic structures. However, currently used irradiation technologies (mostly gamma-rays and high energy electrons) require large and complex shielding constructions to protect the environment from radioactivity or X-rays generated during the process. This excludes them from direct integration into biological production facilities. Here, low-energy electron irradiation (LEEI) is presented as an alternative inactivation method for pathogens in liquid solutions. LEEI can be used in normal laboratories, including good manufacturing practice (GMP)- or high biosafety level (BSL)-environments, as only minor shielding is necessary. We show that LEEI efficiently inactivates different viruses (influenza A (H3N8), porcine reproductive and respiratory syndrome virus (PRRSV), equine herpesvirus 1 (EHV-1)) and bacteria (Escherichia coli) and maintains their antigenicity. Moreover, LEEI-inactivated influenza A viruses elicit protective immune responses in animals, as analyzed by virus neutralization assays and viral load determination upon challenge. These results have implications for novel ways of developing and manufacturing inactivated vaccines with improved efficacy.

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“…Generally, biofouling is generated by the attachment of microorganisms such as cells or bacteria to the surface. To circumvent such problems, a variety of strategies have been developed to modify the surface properties of PDMS by physical modification or chemical covalent methods, including oxygen plasma, ultraviolet light/ozone, polyelectrolyte multilayers, surface activation, and chemical grafting [4][5][6][7][8]. Particularly, polyethylene glycol (PEG) surface modification is an effective method for antifouling purpose [7,9].…”

Section: Introductionmentioning

confidence: 99%

Bottom-Up Fabrication of PEG Brush on Poly(dimethylsiloxane) for Antifouling Surface Construction

Tang

Han

Chen

et al. 2016

International Journal of Polymer Science

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Poly(dimethylsiloxane) silicones have found many applications in biomedical devices, whereas their surface hydrophobicity always brings about unexpected bioadhesion, causing complications of the implanted biomedical devices. In this work, surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization was utilized to generate PEG brushes on silicone surface, obtaining highly hydrophilic surface coatings. Such PEG brush coated silicone presents excellent antifouling to protein, cells, and bacteria, which may have great potential in implantable biomaterial surface modifications.

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Surface modification of polyurethane and silicone for therapeutic medical technics by means of electron beam

Cited by 21 publications

References 17 publications

Synthesis and characterization of phenyl polysiloxane modified polyurea/polyurethanes

Synthesis and characterization of phenyl polysiloxane modified polyurea/polyurethanes

Pathogens Inactivated by Low-Energy-Electron Irradiation Maintain Antigenic Properties and Induce Protective Immune Responses

Bottom-Up Fabrication of PEG Brush on Poly(dimethylsiloxane) for Antifouling Surface Construction

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