Surface Modification of Silica Core−Shell Nanocapsules:  Biomedical Implications

Jovanovic, Aleksa V.; Flint, Jeremy J.; Varshney, Manoj; Morey, Timothy E.; Dennis, Donn M.; Duran, Randolph S.

doi:10.1021/bm050820+

Cited by 42 publications

(39 citation statements)

References 31 publications

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“…Although the good safety profile, biodegradability, and relative manufacturing simplicity make liposomes and ILEs attractive options, ILEs are often criticized for their lack of stability and limited chemical diversity. In recent years, a considerable amount of work has been invested into the development of other biodetoxifying nanostructures, including nanospheres, nanocapsules, and nanotubes (21)(22)(23). Several studies have reported good extraction efficiencies for drugs or heavy metals under in vitro conditions using nanoparticles, but most of the systems investigated so far do not possess optimal properties for an antidotal application in vivo.…”

Section: Liposomesmentioning

confidence: 99%

Nano-antidotes for drug overdose and poisoning

Forster

Leroux

2015

Sci. Transl. Med.

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The number of intoxications from xenobiotics--natural or synthetic foreign chemicals, or substances given in higher doses than typically present in humans--has risen tremendously in the last decade, placing poisoning as the leading external cause of death in the United States. This epidemic has fostered the development of antidotal nanomedicines, which we call "nano-antidotes," capable of efficiently neutralizing offending compounds in situ. Although prototype nano-antidotes have shown efficacy in proof-of-concept studies, the gap to clinical translation can only be filled if issues such as the clinical relevance of intoxication models and the safety profile of nano-antidotes are properly addressed. As the unmet medical needs in resuscitative care call for better treatments, this Perspective critically reviews the recent progress in antidotal medicine and emerging nanotechnologies.

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Section: Liposomesmentioning

confidence: 99%

Nano-antidotes for drug overdose and poisoning

Forster

Leroux

2015

Sci. Transl. Med.

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“…In comparison to TiO 2 , silica (SiO 2 ) has been studied more widely due to an occupational lung disease called silicosis which is linked to crystalline phase silica (Brunner et al, 2006; Jovanovic et al, 2006). Unlike TiO 2 , however, research involving SiO 2 in the field of nanotechnology deals mainly with amorphous phase silica (Bharali et al, 2005; Chowdhury and Akaike, 2005; Gemeinhart et al, 2005).…”

Section: Nano—bio Interface and Nanotoxicologymentioning

confidence: 99%

Nanotechnology, nanotoxicology, and neuroscience

Suh

Suslick

Stucky

et al. 2009

Progress in Neurobiology

373

193

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Nanotechnology, which deals with features as small as a 1 billionth of a meter, began to enter into mainstream physical sciences and engineering some 20 years ago. Recent applications of nanoscience include the use of nanoscale materials in electronics, catalysis, and biomedical research. Among these applications, strong interest has been shown to biological processes such as blood coagulation control and multimodal bioimaging, which has brought about a new and exciting research field called nanobiotechnology. Biotechnology, which itself also dates back ∼30 years, involves the manipulation of macroscopic biological systems such as cells and mice in order to understand why and how molecular level mechanisms affect specific biological functions, e.g., the role of APP (amyloid precursor protein) in Alzheimer's disease (AD). This review aims (1) to introduce key concepts and materials from nanotechnology to a non-physical sciences community; (2) to introduce several stateof-the-art examples of current nanotechnology that were either constructed for use in biological systems or that can, in time, be utilized for biomedical research; (3) to provide recent excerpts in nanotoxicology and multifunctional nanoparticle systems (MFNPSs); and (4) to propose areas in neuroscience that may benefit from research at the interface of neurobiologically important systems and nanostructured materials.

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“…Core-shell 3 Core-shell b Core-shell b Core-shell b "oil core and polymer shell; b polymer core and oil shell.…”

Section: Morphology Predictionmentioning

confidence: 99%

“…catalysts, enzymes, DNAs, medicines, or pigments [1][2][3]. A large number of innovative techniques have been designed to elaborate hollow particles [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%