Surface Modification of Ti–30Ta Alloy by Deposition of P(VDF-TrFE)/BaTiO3 Coating for Biomedical Applications

Ribeiro, Larissa Mayra Silva; Simões, Luziane Aparecida Costa da Rosa; Espanhol-Soares, Melina; Teles, Vinícius; Ribeiro, Tainara Aparecida Nunes; Capellato, Patrícia; Fré, Lucas V. B. V.; Kuffner, Bruna Horta Bastos; Saddow, Stephen E.; Sachs, Daniela; Claro, Ana Paula Rosifini Alves; Gimenes, Rossano

doi:10.3390/met12091409

Cited by 4 publications

(3 citation statements)

References 103 publications

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“…Therefore, the PI is selected for the development of our target device. Both copolymer and terpolymer were shown to be biocompatible and sterilizable [89][90][91], but the copolymer was finally chosen due to its higher ability to bend.…”

Section: Design Guideline Of a Smart Guidewire-based Printed Eapmentioning

confidence: 99%

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Design Optimization of Printed Multi-Layered Electroactive Actuators Used for Steerable Guidewire in Micro-Invasive Surgery

Toinet,

Benwadih,

Szambolics

et al. 2024

Materials

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To treat cardiovascular diseases (i.e., a major cause of mortality after cancers), endovascular-technique-based guidewire has been employed for intra-arterial navigation. To date, most commercially available guidewires (e.g., Terumo, Abbott, Cordis, etc.) are non-steerable, which is poorly suited to the human arterial system with numerous bifurcations and angulations. To reach a target artery, surgeons frequently opt for several tools (guidewires with different size integrated into angulated catheters) that might provoke arterial complications such as perforation or dissection. Steerable guidewires would, therefore, be of high interest to reduce surgical morbidity and mortality for patients as well as to simplify procedure for surgeons, thereby saving time and health costs. Regarding these reasons, our research involves the development of a smart steerable guidewire using electroactive polymer (EAP) capable of bending when subjected to an input voltage. The actuation performance of the developed device is assessed through the curvature behavior (i.e., the displacement and the angle of the bending) of a cantilever beam structure, consisting of single- or multi-stack EAP printed on a substrate. Compared to the single-stack architecture, the multi-stack gives rise to a significant increase in curvature, even when subjected to a moderate control voltage. As suggested by the design framework, the intrinsic physical properties (dielectric, electrical, and mechanical) of the EAP layer, together with the nature and thickness of all materials (EAP and substrate), do have strong effect on the bending response of the device. The analyses propose a comprehensive guideline to optimize the actuator performance based on an adequate selection of the relevant materials and geometric parameters. An analytical model together with a finite element model (FEM) are investigated to validate the experimental tests. Finally, the design guideline leads to an innovative structure (composed of a 10-stack active layer screen-printed on a thin substrate) capable of generating a large range of bending angle (up to 190°) under an acceptable input level of 550 V, which perfectly matches the standard of medical tools used for cardiovascular surgery.

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Section: Design Guideline Of a Smart Guidewire-based Printed Eapmentioning

confidence: 99%

“…biocompatible and sterilizable [89][90][91], but the copolymer was finally chosen due to its higher ability to bend.…”

Section: Design Guideline Of a Smart Guidewire-based Printed Eapmentioning

confidence: 99%

Design Optimization of Printed Multi-Layered Electroactive Actuators Used for Steerable Guidewire in Micro-Invasive Surgery

Toinet,

Benwadih,

Szambolics

et al. 2024

Materials

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show abstract

“…The cytotoxicity test is the first biocompatibility test to be performed before beginning detailed in vivo testing in laboratory animals. To minimize the unnecessary use of test animals, ISO 10993-2 recommends in vitro testing of medical device materials before starting animal testing [29]. This in vitro test is easy to perform and results are available in 2-3 days.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Biocompatibility of Laser Treated 316L Stainless Steel Materials

Aykac

Türkmen

2022

Coatings

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In this study, 316L stainless steel materials, which are widely used in the industry, were produced by investment casting management. Depending on the microstructure, the hardness values constitute an important stage of the properties that can be developed and controlled. For this purpose, the differences between the microstructure and hardness properties of 316L stainless steel, which is produced by the investment casting method, and 316L stainless steel, which is currently used commercially, were examined. The changes caused by the fiber laser on the surface of 316L materials produced with two different production methods were examined. It was observed that the laser used made different changes in the surface structure of the 316L material produced by both methods. Since the surface of the material is a buffer between body fluids and biomaterial, it is known that there is a relationship between surface properties and biocompatibility. In this study, the L929 cell growth test, one of the cytotoxicity tests, was applied and thus, how laser surface treatment affects the biocompatibility of 316L materials produced by both methods was comparatively examined.

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Hemocompatibility and Antioxidant Properties of Nano-Sized Barium Titanate in Cubic and Tetragonal System

Ivanov,

Filimonova,

Sirotkin

et al. 2024

J Clust Sci

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Surface Modification of Ti–30Ta Alloy by Deposition of P(VDF-TrFE)/BaTiO3 Coating for Biomedical Applications

Cited by 4 publications

References 103 publications

Design Optimization of Printed Multi-Layered Electroactive Actuators Used for Steerable Guidewire in Micro-Invasive Surgery

Design Optimization of Printed Multi-Layered Electroactive Actuators Used for Steerable Guidewire in Micro-Invasive Surgery

Investigation of the Biocompatibility of Laser Treated 316L Stainless Steel Materials

Hemocompatibility and Antioxidant Properties of Nano-Sized Barium Titanate in Cubic and Tetragonal System

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