Surface modification of titanium implants by silk fibroin/Ag co-functionalized strontium titanate nanotubes for inhibition of bacterial-associated infection and enhancement of in vivo osseointegration

Wang, Bingbing; Wu, Zongze; Lan, Jinping; Li, Yichao; Xie, Lei; Huang, Xiao; Zhang, Aiqian; Qiao, Hongchao; Chang, Xiaotong; Lin, He; Zhang, Hui; Li, Tingting; Huang, Yong

doi:10.1016/j.surfcoat.2020.126700

Cited by 68 publications

(37 citation statements)

References 59 publications

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“…79 Several new approaches have been developed to cope with the bacterial colonization, including antibacterial therapy, 70,80,81 vaccinating implanted biomaterials to increase the efficiency of dendritic immune cells against bacterial attack, 82 controlled release of soluble toxic agents into the adjacent surrounding tissue, and by targeted delivery of artificial molecules that aid and accelerate the binding of neutrophils to the bacteria. 83,84 Degradation and resorption is part of any tissue-engineered product. Often tissue-engineered biomaterials are biodegradable, and the degradation process is either chemically driven or it is accomplished by cells.…”

Section: Essential Biological Aspects Of Biomaterialsmentioning

confidence: 99%

Engineering biomaterials to 3D-print scaffolds for bone regeneration: practical and theoretical consideration

et al. 2022

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Section: Essential Biological Aspects Of Biomaterialsmentioning

confidence: 99%

Engineering biomaterials to 3D-print scaffolds for bone regeneration: practical and theoretical consideration

et al. 2022

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“…Enhances cell proliferation [49,[113][114][115][116][117][118][119][120][121][122][123]; enhances the effect of BMP-2 [116]; enhances angiogenesis [118,121,124]…”

Section: In Vitromentioning

confidence: 99%

“…This made the surface of the implant materials, such as ultra-high-molecular-weight polyethylene, more hydrophilic [ 127 ]. In addition, silk fibroin, with its surface roughness, improved the adhesion and proliferation of cells that had difficulty settling on the implant due to chemical inertness and the poor interfacial adhesion of the implant itself [ 122 , 127 ]. The immobilization of VEGF on hydroxyapatite coatings can be improved by ion substitution with silicone, which at lower levels alters the surface of the implant in a manner suitable for osteoblasts.…”

Section: Bioactive Coatings and Gfsmentioning

confidence: 99%

The Role of Growth Factors in Bioactive Coatings

Bjelić

Finšgar

2021

Pharmaceutics

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With increasing obesity and an ageing population, health complications are also on the rise, such as the need to replace a joint with an artificial one. In both humans and animals, the integration of the implant is crucial, and bioactive coatings play an important role in bone tissue engineering. Since bone tissue engineering is about designing an implant that maximally mimics natural bone and is accepted by the tissue, the search for optimal materials and therapeutic agents and their concentrations is increasing. The incorporation of growth factors (GFs) in a bioactive coating represents a novel approach in bone tissue engineering, in which osteoinduction is enhanced in order to create the optimal conditions for the bone healing process, which crucially affects implant fixation. For the application of GFs in coatings and their implementation in clinical practice, factors such as the choice of one or more GFs, their concentration, the coating material, the method of incorporation, and the implant material must be considered to achieve the desired controlled release. Therefore, the avoidance of revision surgery also depends on the success of the design of the most appropriate bioactive coating. This overview considers the integration of the most common GFs that have been investigated in in vitro and in vivo studies, as well as in human clinical trials, with the aim of applying them in bioactive coatings. An overview of the main therapeutic agents that can stimulate cells to express the GFs necessary for bone tissue development is also provided. The main objective is to present the advantages and disadvantages of the GFs that have shown promise for inclusion in bioactive coatings according to the results of numerous studies.

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“…However, in clinical application, the presence of metallic implants will induce foreign body reaction and impair the immune system around the implants, causing bacteria to colonize [ 3 ]. Unfortunately, titanium and titanium alloys lack antibacterial ability, and bacterial infection has become a serious complication that leads to implant failure [ [4] , [5] , [6] ].…”

Section: Introductionmentioning

confidence: 99%

Porous thermosensitive coating with water-locking ability for enhanced osteogenic and antibacterial abilities

Hao

Zhou

Xie

et al. 2022

Materials Today Bio

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Surface modification of titanium implants by silk fibroin/Ag co-functionalized strontium titanate nanotubes for inhibition of bacterial-associated infection and enhancement of in vivo osseointegration

Cited by 68 publications

References 59 publications

Engineering biomaterials to 3D-print scaffolds for bone regeneration: practical and theoretical consideration

Engineering biomaterials to 3D-print scaffolds for bone regeneration: practical and theoretical consideration

The Role of Growth Factors in Bioactive Coatings

Porous thermosensitive coating with water-locking ability for enhanced osteogenic and antibacterial abilities

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