Surface modification of tricalcium phosphate for improvement of the interfacial compatibility with biodegradable polymers

Kunze, Carmen; Freier, Thomas; Helwig, Ekaterina; Sandner, B.; Reif, David M.; Wutzler, A.; Radusch, Hans‐Joachim

doi:10.1016/s0142-9612(02)00433-7

Cited by 46 publications

(33 citation statements)

References 16 publications

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“…It is worth mentioning that HAPEX has been successfully commercialized for middle-ear implant applications and to date it has been implanted in over 300 000 patients with very successful outcomes. In the case of bioabsorbable composites, the bioabsorbable polymer matrix is reinforced with a bioactive reinforcing phase such as HA, several CaPs and BGs (Kasuga et al 2003;Kunze et al 2003;Jaakkola et al 2004;Navarro et al 2005). The aim is to obtain a material with mechanical properties similar to those of bone that can form bioactive bonding with bone tissue and where the degradation process matches the healing period of the fracture or lesion.…”

Section: Polymersmentioning

confidence: 99%

Biomaterials in orthopaedics

Navarro

Michiardi

Castaño

et al. 2008

J. R. Soc. Interface.

1,284

730

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At present, strong requirements in orthopaedics are still to be met, both in bone and joint substitution and in the repair and regeneration of bone defects. In this framework, tremendous advances in the biomaterials field have been made in the last 50 years where materials intended for biomedical purposes have evolved through three different generations, namely first generation (bioinert materials), second generation (bioactive and biodegradable materials) and third generation (materials designed to stimulate specific responses at the molecular level). In this review, the evolution of different metals, ceramics and polymers most commonly used in orthopaedic applications is discussed, as well as the different approaches used to fulfil the challenges faced by this medical field.

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Section: Polymersmentioning

confidence: 99%

Biomaterials in orthopaedics

Navarro

Michiardi

Castaño

et al. 2008

J. R. Soc. Interface.

1,284

730

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“…Low intensity of O-H valence band in the region 3100-3600 cm -1 and band of crystal water of surface-activated TCP were clearly observed. The neat PLLA has the characteristic carbonyl band at 1750 cm -1 , C-H stretching band at 2920 and 3000 cm -1 , and C-H bending band at 1450 and 1360 cm -1 [13,14]. The IR spectrum PLLA-g-TCP shows that PLLA was successfully grafted onto TCP surfaces.…”

Section: Resultsmentioning

confidence: 98%

“…These powders were washed five times with distilled water to completely remove free residual PO 4 3-ions, and dried at 60°C under vacuum before used. Evacuation was used to minimize residual water in order to reduce the formation of ungrafted PLLA and L-lactide hydrolisis [13,14]. The dry surface-modified TCP powder was grafted by L-lactide through ring-opening polymerization using stannous octoate as catalyst.…”

Section: Grafting Of Lactide Onto Surface-modifiedmentioning

confidence: 99%

Preparation and characterization of a stereocomplex of poly(lactide-co-ε-caprolactone)/tricalcium phosphate biocomposite using supercritical fluid technology

Nurqadar¹,

Purnama²,

Kim³

2013

Express Polym. Lett.

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Absorbable materials are attractive for internal fracture fixation devices. They have advantages in the reduction of stress shielding, secondary operations for removal are no longer required, and the risks of complications are reduced [1]. Biopolymers such as polylactide, poly(glycolic acid), poly(!-caprolactone), and their copolymers attract great attention due to their biodegradability and biocompatibility. The major limitation of those materials is that their mechanical properties (as strength, toughness, elastic modulus) are lower than the mechanical properties of cortical bones. Abstract. A novel biocomposite material from a stereocomplex of poly (L-lactide-co-!-caprolactone) (PLLCL) and poly (D-lactide-co-!-caprolactone) (PDLCL) and inorganic tricalcium phosphate (TCP) was prepared by supercritical fluid method. Both pristine and poly (L-lactide)-grafted-TCP (PLLA-g-TCP) were used. PLLA-g-TCP was produced by ringopening polymerization of L-lactide in the presence of surface-activated TCP. Infrared (IR) spectroscopy and scanning electron microscopic (SEM) images confirm the attachment of PLLA onto the activated TCP surface. The stereocomplex formation of biocomposite was confirmed by differential scanning calorimetry (DSC) and wide-angle X-ray diffraction (WAXD). The biocomposite containing PLLA-g-TCP has higher stereocomplex degree and more homogeneous TCP distribution compared to the biocomposite containing pristine TCP. The presence of PLLA-g-TCP in the stereocomplex PLLCL-PDLCL (s-PDLCL) enhance the stereocomplex degree up to a certain content and also supports the homogeneous TCP dispersion in the stereocomplex matrix. These phenomena support the improvement in mechanical properties of the s-PDLCL composite the optimum content of PLLA-g-TCP being 10%. The biocomposites containing TCP materials are promising materials for biomedical application, especially for bone tissue engineering.

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“…The powders were stirred with 5% dilute aqueous phosphoric acid (1∶2 w/w) to form the active group onβ-TCP phase surface by the surface reaction Ca 3 (PO 4 ) 2 +H 3 PO 4 +2H 2 O→3CaHPO 4 ·2H 2 O [27] . After that, BCP powders were surface-activated (HA phase has its structure active group hydroxyl).…”

Section: Surface Modification Of Bcp Powdersmentioning

confidence: 99%

Surface-modified biphasic calcium phosphate/poly (L-lactide) biocomposite

Yang

Yin

Zhou

et al. 2009

J. Wuhan Univ. Technol.-Mat. Sci. Edit.

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Biphasic calcium phosphate (BCP) powders were prepared by hydrolyzation process and surface-modified by directly grafted L-lactide (LLA) onto the surface of BCP through a chemical linkage. The grafting ratio of organic groups was 9 wt%. After surface modification, the surface of BCP powders was covered by the lamella-shaped crystal. Poly (L-lactide) was mixed with BCP to form the BCP/PLLA biocomposite. Modified BCP (mBCP) particles could be uniformly dispersed in PLLA matrix. The compressive strength of the mBCP/PLLA composite is 115 MPa, 28% higher than that of unmodified-BCP/PLLA composite. The improved mechanical strength is attributed to the enhanced adhesion between the inorganic BCP filler and the organic PLLA matrix.

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Surface modification of tricalcium phosphate for improvement of the interfacial compatibility with biodegradable polymers

Cited by 46 publications

References 16 publications

Biomaterials in orthopaedics

Biomaterials in orthopaedics

Preparation and characterization of a stereocomplex of poly(lactide-co-ε-caprolactone)/tricalcium phosphate biocomposite using supercritical fluid technology

Surface-modified biphasic calcium phosphate/poly (L-lactide) biocomposite

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