Surface Modification Techniques for Endothelial Cell Seeding in PDMS Microfluidic Devices

Akther, Fahima; Yakob, Shazwani Binte; Nguyen, Nam‐Trung; Ta, Hang T.

doi:10.3390/bios10110182

Cited by 132 publications

(120 citation statements)

References 89 publications

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“…Among polymers, there is an increasing interest in the study of polydimethylsiloxane (PDMS) for applications such as mechanical and civil engineering, electronic devices, and in biomedical fields [2][3][4][5][6][7]. Within these areas, applications were reported such as water/oil and gas filtration membranes [8][9][10], sensors [11][12][13], lubricants [14], sealing agents [15], blood analogues [16][17][18], and also for microfluidic devices [19][20][21][22][23]. Recently, there has been a significant growing interest in microelectromechanical systems (MEMS) and microfluidic and optical devices [24].…”

Section: Introductionmentioning

confidence: 99%

Composite Material of PDMS with Interchangeable Transmittance: Study of Optical, Mechanical Properties and Wettability

et al. 2021

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Polydimethylsiloxane (PDMS) is a polymer that has attracted the attention of researchers due to its unique properties such as transparency, biocompatibility, high flexibility, and physical and chemical stability. In addition, PDMS modification and combination with other materials can expand its range of applications. For instance, the ability to perform superhydrophobic coating allows for the manufacture of lenses. However, many of these processes are complex and expensive. One of the most promising modifications, which consists of the development of an interchangeable coating, capable of changing its optical characteristics according to some stimuli, has been underexplored. Thus, we report an experimental study of the mechanical and optical properties and wettability of pure PDMS and of two PDMS composites with the addition of 1% paraffin or beeswax using a gravity casting process. The composites’ tensile strength and hardness were lower when compared with pure PDMS. However, the contact angle was increased, reaching the highest values when using the paraffin additive. Additionally, these composites have shown interesting results for the spectrophotometry tests, i.e., the material changed its optical characteristics when heated, going from opaque at room temperature to transparent, with transmittance around 75%, at 70 °C. As a result, these materials have great potential for use in smart devices, such as sensors, due to its ability to change its transparency at high temperatures.

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Section: Introductionmentioning

confidence: 99%

Composite Material of PDMS with Interchangeable Transmittance: Study of Optical, Mechanical Properties and Wettability

et al. 2021

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“…Additionally, PDMS is readily commercially available and easy to manufacture (spin-coating [ 186 ], molding [ 187 ]). PDMS is suitable for flexible electronic substrates because it is not damaged by chemicals [ 188 , 189 , 190 , 191 ] and has high transparency, low weight, and excellent formability for application in mechanical and medical devices [ 91 , 192 , 193 , 194 ].…”

Section: Classification Of Materialsmentioning

confidence: 99%

Review: Sensors for Biosignal/Health Monitoring in Electronic Skin

Lee

Kim

et al. 2021

Polymers

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Skin is the largest sensory organ and receives information from external stimuli. Human body signals have been monitored using wearable devices, which are gradually being replaced by electronic skin (E-skin). We assessed the basic technologies from two points of view: sensing mechanism and material. Firstly, E-skins were fabricated using a tactile sensor. Secondly, E-skin sensors were composed of an active component performing actual functions and a flexible component that served as a substrate. Based on the above fabrication processes, the technologies that need more development were introduced. All of these techniques, which achieve high performance in different ways, are covered briefly in this paper. We expect that patients’ quality of life can be improved by the application of E-skin devices, which represent an applied advanced technology for real-time bio- and health signal monitoring. The advanced E-skins are convenient and suitable to be applied in the fields of medicine, military and environmental monitoring.

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“…Silanol-functional groups (SiOH) are also created on the PMDS surface. Contact between the silanol groups results in the formation of siloxane bridges (Si-O-Si) on the PDMS surface [ 96 ]. This allows permanent bonding of the PDMS surface with glass, or another PDMS surface, without requiring an adhesive.…”

Section: Organs-on-a-chipmentioning

confidence: 99%

Cystic Fibrosis Human Organs-on-a-Chip

et al. 2021

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Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most epithelial cells. Major clinical features of CF include respiratory failure, pancreatic exocrine insufficiency, and intestinal disease. Many CF animal models have been generated, but some models fail to fully capture the phenotypic manifestations of human CF disease. Other models that better capture the key characteristics of the human CF phenotype are cost prohibitive or require special care to maintain. Important differences have been reported between the pathophysiology seen in human CF patients and in animal models. These limitations present significant limitations to translational research. This review outlines the study of CF using patient-derived organs-on-a-chip to overcome some of these limitations. Recently developed microfluidic-based organs-on-a-chip provide a human experimental model that allows researchers to manipulate environmental factors and mimic in vivo conditions. These chips may be scaled to support pharmaceutical studies and may also be used to study organ systems and human disease. The use of these chips in CF discovery science enables researchers to avoid the barriers inherent in animal models and promote the advancement of personalized medicine.

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Surface Modification Techniques for Endothelial Cell Seeding in PDMS Microfluidic Devices

Cited by 132 publications

References 89 publications

Composite Material of PDMS with Interchangeable Transmittance: Study of Optical, Mechanical Properties and Wettability

Composite Material of PDMS with Interchangeable Transmittance: Study of Optical, Mechanical Properties and Wettability

Review: Sensors for Biosignal/Health Monitoring in Electronic Skin

Cystic Fibrosis Human Organs-on-a-Chip

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