Surface modification techniques of titanium and titanium alloys for biomedical dental applications: A review

Kurup, Alekh; Dhatrak, Pankaj; Khasnis, Neha

doi:10.1016/j.matpr.2020.06.163

Cited by 106 publications

(57 citation statements)

References 40 publications

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“…Titanium oxide has been introduced as a new material in dentistry due to its catalytic activity and biocompatibility [ 15 ]. It has also been reported that root canal sealers containing titanium oxide have antimicrobial components [ 23 ] and these materials can improve mechanical properties [ 24 ], including fracture resistance, compressive strength, flexural strength, and microtensile bond strength [ 25 ]. In this study, the antimicrobial properties of the materials were not examined, so it would be better to consider this in future studies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA

Alimohammadi

Mirzaee-Rad

Feizi

et al. 2021

International Journal of Biomaterials

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Due to the widespread use of MTA in dentistry and various brands of this product, we decided to compare the three brands available in the country market by their biocompatibility. We divided 20 male Wistar rats into four groups. After local anesthesia and washing, we made two incisions on both sides (4 incisions in total). The experimental groups were Angelus MTA (Angelus, Brazil), BioMTA (CERKAMED, Poland), Root MTA (Dr. Lotfi, Tabriz, Iran), and the control group. The resulting paste was placed in a tube and implanted subcutaneously into male Wistar rats. Wistar rats were sacrificed 7, 15, 30, and 60 days later, with high anesthetic doses. The sample implanted in 10% formalin was stabilized after tissue processing and H&E staining under a microscope. The inflammatory reaction in the tissues received different scores at the beginning of the tube opening. BioMTA had the highest inflammatory response among the groups, but the difference was not statistically significant ( p > 0.05). Also, there was no significant difference between the groups’ granulation and calcification ( p < 0.05). There was a significant difference between BioMTA, Angelus MTA, Root MTA, and control groups in fibrous capsule formation ( p < 0.05). Angelus MTA showed the lowest mean fibrous capsule formation in all periods. The effects of Angelus MTA, Root MTA, and BioMTA on connective tissue were investigated and compared. According to this study, these materials have good biocompatibility. According to the findings and statistical analysis, Angelus MTA has the most biocompatibility.

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Section: Discussionmentioning

confidence: 99%

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA

Alimohammadi

Mirzaee-Rad

Feizi

et al. 2021

International Journal of Biomaterials

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“…Titanium is considered to be the most biocompatible of the metals due to its resistance to corrosion in body fluids and bio-inertness [ 10 , 45 , 46 ]. The strength of titanium is due to a protective oxide film that forms naturally in the presence of oxygen found in body fluids [ 47 ].…”

Section: Incremental Sheet Forming Towards Biomedical Applicationsmentioning

confidence: 99%

Single-Point Incremental Forming of Titanium and Titanium Alloy Sheets

et al. 2021

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Incremental sheet forming of titanium and its alloys has a significant role in modern manufacturing techniques because it allows for the production of high-quality products with complex shapes at low production costs. Stamping processes are a major contributor to plastic working techniques in industries such as automotive, aerospace and medicine. This article reviews the development of the single-point incremental forming (SPIF) technique in titanium and its alloys. Problems of a tribological and microstructural nature that make it difficult to obtain components with the desired geometric and shape accuracy are discussed. Great emphasis is placed on current trends in SPIF of difficult-to-form α-, α + β- and β-type titanium alloys. Potential uses of SPIF for forming products in various industries are also indicated, with a particular focus on medical applications. The conclusions of the review provide a structured guideline for scientists and practitioners working on incremental forming of titanium and titanium alloy sheets. One of the ways to increase the formability and minimize the springback of titanium alloys is to treat them at elevated temperatures. The main approaches developed for introducing temperature into a workpiece are friction heating, electrical heating and laser heating. The selection of an appropriate lubricant is a key aspect of the forming process of titanium and its alloys, which exhibit unfavorable tribological properties such as high adhesion and a tendency to adhesive wear. A review of the literature showed that there are insufficient investigations into the synergistic effect of rotational speed and tool rotation direction on the surface roughness of workpieces.

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“…Simultaneously with the shift to miniaturization of surface topography, the spotlight of the biomaterial field moved also to more complex systems based on interdisciplinary works, such as materials design, surface functionalization, nanomanufacturing of devices, and tissue engineering [ 11 ]. Among these, the modification of the surface properties of biomaterials (surface nanoscale topography, physical properties, and surface chemistry) [ 9 , 12 , 13 ] is a critical factor affecting the biocompatibility and efficiency of drug delivery and other biomedical applications [ 10 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Especially for biomaterials targeting dental/orthopedic bone regeneration, a good osteoinduction and optimal osseointegration with necessary mechanical properties are key aspects to consider.…”

Section: Introductionmentioning

confidence: 99%

“…The relevant surface modification methods include so far: (a) mechanical methods (grinding, machining, etc.) [ 13 , 22 ], (b) acidic treatments (e.g., sulfuric or hydrochloric acid for cleaning, inducing some roughness and a more efficient deposition of additional bioactive layers) [ 13 , 23 , 24 ], (c) hydrogen peroxide [ 25 , 26 ], (d) hydroxyapatite coatings on Ti either by micro-arc oxidation, sol-gel methods or plasma spraying [ 27 , 28 , 29 , 30 ], (e) silver (Ag) coatings on Ti by plasma sputtering of other Ag containing diamond-like carbon coatings on Ti [ 31 , 32 , 33 ], (f) electrochemical anodization allowing a nanostructured layer (nanopores, nanotubes or mesosponge) to grow directly on the metallic biomaterial (Ti or Ti alloys) [ 9 , 34 ]. These mechanical, physical, or chemical methods enable morphological surface modification and can be combined with the addition of a coating layer on the Ti or Ti alloys surface.…”

Section: Introductionmentioning

confidence: 99%

Anodic TiO2 Nanotubes: Tailoring Osteoinduction via Drug Delivery

et al. 2021

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TiO2 nanostructures and more specifically nanotubes have gained significant attention in biomedical applications, due to their controlled nanoscale topography in the sub-100 nm range, high surface area, chemical resistance, and biocompatibility. Here we review the crucial aspects related to morphology and properties of TiO2 nanotubes obtained by electrochemical anodization of titanium for the biomedical field. Following the discussion of TiO2 nanotopographical characterization, the advantages of anodic TiO2 nanotubes will be introduced, such as their high surface area controlled by the morphological parameters (diameter and length), which provides better adsorption/linkage of bioactive molecules. We further discuss the key interactions with bone-related cells including osteoblast and stem cells in in vitro cell culture conditions, thus evaluating the cell response on various nanotubular structures. In addition, the synergistic effects of electrical stimulation on cells for enhancing bone formation combining with the nanoscale environmental cues from nanotopography will be further discussed. The present review also overviews the current state of drug delivery applications using TiO2 nanotubes for increased osseointegration and discusses the advantages, drawbacks, and prospects of drug delivery applications via these anodic TiO2 nanotubes.

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Surface modification techniques of titanium and titanium alloys for biomedical dental applications: A review

Cited by 106 publications

References 40 publications

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA

Single-Point Incremental Forming of Titanium and Titanium Alloy Sheets

Anodic TiO2 Nanotubes: Tailoring Osteoinduction via Drug Delivery

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