Surface Modifications of Nanodiamonds and Current Issues for Their Biomedical Applications

Arnault, Jean-Charles

doi:10.1007/978-3-030-12469-4_12

Cited by 16 publications

(16 citation statements)

References 254 publications

(322 reference statements)

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“…The broad pH regions with a decrease of ζ-potentials at the increasing pH are characteristic for nanodiamonds, 74,75 while the exact match of ζ-potential decrease areas to the observed ones can be found only in some of the oxidized CNPs. 76,77 The pH range studied here can be divided into distinct regions as follows.…”

Section: Resultsmentioning

confidence: 99%

Surface Photoluminescence of Oxidized Nanodiamonds: Influence of Environment pH

et al. 2021

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Nanoparticles’ environment, in particular pH, can strongly affect their photoluminescence (PL). This can be especially true for the surface PL of nanodiamonds (NDs) known to be dependent on the composition of surface groups. In this paper, the effect of environmental pH in the range from 2 to 12.5 on the surface photoluminescence of oxidized NDs of various syntheses and surface treatments was investigated. For the first time, the varying changes of the NDs’ PL with the pH were shown, having, however, an essential common feature: they were observed in the same pH regions from 2 to 5 and from 9 to 12.5, while in the pH region from 5 to 9, the PL intensity of all samples was almost constant. Obtained dependences of NDs’ ζ-potentials on pH and quantum mechanical modeling showed that all changes of NDs’ PL are due to the (de)protonation of surface groups: carboxyl at pH from 2 to 5 and hydroxyl on sp2-hybridized carbon at pH from 9 to 12.5. The varying response of NDs’ PL to such deprotonation shows the possibility of tuning the surface photoluminescence of NDs for use in industry and biomedicine beyond what is possible by only controlling the nanodiamonds’ surface groups.

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Section: Resultsmentioning

confidence: 99%

Surface Photoluminescence of Oxidized Nanodiamonds: Influence of Environment pH

et al. 2021

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“…For diamonds, the binary distribution appears in two variants: as the isotopic-induced disorder and in the form of substitutional nitrogen impurities. In the former case m corresponds to 12 C atom and m+δm is the 13 C atomic mass which yields δm/m = (13 − 12)/12 = 1/12. When the nitrogen atoms are considered, the effect is not so obvious.…”

Section: B Binary Disorder In Discrete Modelmentioning

confidence: 99%

“…Manufacturing, characterization, investigation and application of diverse small particles and, particularly, of crystalline dielectric and semiconducting nanoparticles are among the most important and intensively developing areas of contemporary scientific research and technology. The role of nanoparticle studies in domains of optics, quantum computing, chemistry, and material science permanently grows [1][2][3][4][5][6][7][8][9]; various applications penetrate biology and medicine, the nanoparticles being used as dyes, carriers, and imaging systems [10][11][12][13][14][15]. This imposes the strict necessity for tools and methods of their physical and chemical characterization [16,17], the particle size is important parameter to know.…”

Section: Introductionmentioning

confidence: 99%

Lifetimes of confined optical phonons and the shape of a Raman peak in disordered nanoparticles. II. Numerical treatment

2020

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Disorder-induced broadening of optical vibrational eigenmodes in nanoparticles of nonpolar crystals is studied numerically. The methods previously used to treat phonons in defectless particles are adjusted for numerical evaluation of the disordered problem. Imperfections in the form of Gaussian and binary disorders as well as surface irregularities are investigated thoroughly in a wide range of impurity concentrations and disorder strengths. For dilute and weak point-like impurities the regimes of separated and overlapped phonon levels are obtained and the behavior of the linewidth predicted theoretically is confirmed, the crossover scale falls into the actual range of several nanometers. These notions survive for strong dilute impurities, as well. Regimes and crossovers predicted by theory are checked and identified, and minor discrepancies are discussed. To mention a few of them: slower than in theory increasing of the linewidth with the phonon quantum number for weak disorder and only qualitative agreement between theory and numerics for resonant broadening in strong dilute disorder. The novel phenomena discovered numerically are: "mesoscopic smearing" of distribution function in the ensemble of identical disordered particles, inflection of the linewidth dependence on the impurity concentration for light "dense" binary impurities, and position dependent capability of strong impurity to catch the phonon. It is shown that surface irregularities contribute to the phonon linewidth less than the volume disorder, and their rate reveal faster decay with increasing of the particle size. It is argued that the results of present research are applicable also for quantum dots and short quantum wires.

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“…NDs’ fluorescence [26,27,28], Raman scattering [27], and backscattered signal (differential interference and Hoffman modulation ‘space’ contrast microscopy techniques) [28] have been utilized for multimodal imaging and delivery monitoring. The surface properties of NDs allow the functionalization of the particles with molecules of interests for interaction with bio-targets [24,25,29]. Importantly, in anticancer therapy, ND-mediated delivery has been shown to increase the efficiency of drug treatment [30].…”

Section: Introductionmentioning

confidence: 99%

Optical Studies of Nanodiamond-Tissue Interaction: Skin Penetration and Localization

et al. 2019

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In this work, several optical-spectroscopic methods have been used to visualize and investigate the penetration of diamond nanoparticles (NPs) of various sizes (3–150 nm), surface structures and fluorescence properties into the animal skin in vitro. Murine skin samples have been treated with nanodiamond (ND) water suspensions and studied using optical coherence tomography (OCT), confocal and two-photon fluorescence microscopy and fluorescence lifetime imaging (FLIM). An analysis of the optical properties of the used nanodiamonds (NDs) enables the selection of optimal optical methods or their combination for the study of nanodiamond–skin interaction. Among studied NDs, particles of 100 nm in nominal size were shown to be appropriate for multimodal imaging using all three methods. All the applied NDs were able to cross the skin barrier and penetrate the different layers of the epidermis to finally arrive in the hair follicle niches. The results suggest that NDs have the potential for multifunctional applications utilizing multimodal imaging.

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Surface Modifications of Nanodiamonds and Current Issues for Their Biomedical Applications

Cited by 16 publications

References 254 publications

Surface Photoluminescence of Oxidized Nanodiamonds: Influence of Environment pH

Surface Photoluminescence of Oxidized Nanodiamonds: Influence of Environment pH

Lifetimes of confined optical phonons and the shape of a Raman peak in disordered nanoparticles. II. Numerical treatment

Optical Studies of Nanodiamond-Tissue Interaction: Skin Penetration and Localization

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