Surface-modified CoFe2O4 nanoparticles using Folate-Chitosan for cytotoxicity Studies, hyperthermia applications and Positive/Negative contrast of MRI

Nahar, A.; Maria, Kazi Hanium; Liba, Samia Islam; Anwaruzzaman, Md.; Khan, M. N. I.; Islam, Aminul; Choudhury, Subhashree; Hoque, S. Manjura

doi:10.1016/j.jmmm.2022.169282

Cited by 16 publications

(9 citation statements)

References 53 publications

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“…Figure 8c reveals that the SLP of concentration 0.25 mg ml −1 is the highest with a value of 501.6 W g −1 , while the SLP of concentration 4.0 mg ml −1 is the lowest, 35.53 W g −1 ; thus, the SLP decreases with the increase of concentrations. Decreasing the value of SLP with the increase in concentration was also observed in the previous studies [78][79][80][81]. The specific loss power and the maximum temperature, T max , in figure 8 are remarkable, when we consider the magnetization as M max , 300 K = 1.98 emu g −1 with the applied field 9 T in this study.…”

Section: Resultssupporting

confidence: 87%

Enhanced specific loss power of hematite–chitosan nanohybrid synthesized by hydrothermal method

Deb,

Rashid,

Das

et al. 2023

R. Soc. open sci.

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We used a hydrothermal technique to develop nano-scale α-Fe 2 O 3 particles and functionalized them with chitosan. An X-ray diffraction study revealed α-Fe 2 O 3 nanoparticles were of single-phase, lattice constants were a = 5.07 Å and c = 13.68 Å, and the grain size was 27 nm. The presence of lattice fringes in the HRTEM image confirmed the crystalline nature of the α-Fe 2 O 3 . The Mössbauer spectra reveal a mixed relaxation state, which supports the PPMS studies. Zero-field cooled studies revealed the existence of a Morin transition and blocking temperature. The z-average value of the coated particles by DLS was between 218 and 235 nm, PDI ranged from 0.048 to 0.119, and zeta potential was +46.8 mV. We incubated the Vero and HeLa cell lines for 24 h to study the viability of the nanohybrids at different concentrations. Hyperthermia studies revealed the maximum temperature and specific loss power attained by the hematite–chitosan nanohybrid solution of a concentration between 0.25–4 mg ml −1 . The T max at the lowest and highest concentrations of 0.25 and 4 mg ml −1 were 42.9 and 48.3°C, while the SLP were 501.6 and 35.5 W g −1 , which are remarkably high when the maximum magnetization of α-Fe 2 O 3 nanoparticles was as small as 1.98 emu g −1 at 300 K.

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Section: Resultssupporting

confidence: 87%

Enhanced specific loss power of hematite–chitosan nanohybrid synthesized by hydrothermal method

Deb,

Rashid,

Das

et al. 2023

R. Soc. open sci.

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“…Previously, Nahar et al (2022) reported that folate chitosan-coated CFNs decreased around 5% viability of human cervical cancer HeLa cells at a 500 μg/mL concentration. Furthermore, at a concentration of 6000 g/mL, the number of viable HeLa cells decreased by about 25%, while CFNs displayed potent anticancer activity toward MCF-7 breast cancer and HepG-2 liver cancer cells with IC 50 values of 45.12 and 61.86 μg/mL, respectively . As some of the drug candidates including nanoparticles interact with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide dye and produce misleading results, assessing the cell viability using a sulforhodamine B assay could better represent CCN potency …”

Section: Discussionmentioning

confidence: 99%

“…CCN decreased 10−20% of viability of A172 cells. Previously, Nahar et al (2022) 25 reported that folate chitosan-coated CFNs decreased around 5% viability of human cervical cancer HeLa cells at a 500 μg/mL concentration. Furthermore, at a concentration of 6000 g/ mL, the number of viable HeLa cells decreased by about 25%, 25 while CFNs displayed potent anticancer activity toward MCF-7 breast cancer and HepG-2 liver cancer cells with IC 50 values of 45.12 and 61.86 μg/mL, respectively.…”

Section: Discussionmentioning

confidence: 99%

Progeny Transfer Effects of Chitosan-Coated Cobalt Ferrite Nanoparticles

et al. 2023

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Cobalt ferrite nanoparticles (CFNs) are promising materials for their enticing properties for different biomedical applications, including magnetic resonance imaging (MRI) contrast, drug carriers, biosensors, and many more. In our previous study, a chitosan-coated CFN (CCN) nanocomplex demonstrated potential as an MRI contrast dye by improving the biocompatibility of CFN. In this study, we report the progeny transfer effects of CCN following a single intravenous injection of CCN (20, 40, or 60 mg/kg) in pregnant albino Wistar rats. Biochemical and histological observation reveals that CCN is tolerated with respect to maternal organ functions (e.g., liver, kidney). Atomic absorption spectroscopy results showed that CCN or CCN-leached iron could cross the placental barrier and deposit in the fetus. Furthermore, this deposition accelerated lipid peroxidation in the placenta and fetus.

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“…The less concentrated samples were found to be biocompatible but at higher concentrations of 4-6 mg/mL a noticeable decline in HeLa cell viability was observed. The study suggested FCCF NPs at low concentrations could attain hyperthermia temperature and are also biocompatible (Nahar et al, 2022).…”

Section: Physical Modificationmentioning

confidence: 94%

Surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells

Dhiman¹

2022

Preprint

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Magnetic hyperthermia is emerging as a promising alternative to the currently available cancer treatment modalities. Superparamagnetic iron-oxide nanoparticles (SPIONs) are extensively studied functional nanomaterials for biomedical applications, owing to their tunable physio-chemical properties and magnetic properties. Out of various ferrite classes, spinel and inverse-spinel ferrites are widely used but are affected by particle size distribution, particle shape, particle-particle interaction, geometry and crystallinity. Notably, their heating ability makes them suitable candidates for heat-mediated cancer cell ablation or hyperthermia therapy. Exposing SPIONs to an externally applied magnetic field of appropriate frequency and intensity cause them to release heat to ablate cancer cells. Majorly, three heating mechanisms are exhibited by magnetic nanomaterials: Nèel relaxation, Brownian relaxation and hysteresis losses. In SPIONs, Nèel and Brownian relaxations dominate whereas hysteric losses are negligible. These nanomaterials possess high magnetization values capable of generating heat to ablate cancer cells. Furthermore, surface functionalization of these materials imparts the ability to selectively target cancer cells and deliver cargo to the affected area sparing the normal body cells. The surface of nanoparticles can be functionalized with various physical, chemical and biological coatings. Moreover, hyperthermia can be applied in combination with other cancer treatment modalities in order to enhance the efficiency of treatment.

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Surface-modified CoFe2O4 nanoparticles using Folate-Chitosan for cytotoxicity Studies, hyperthermia applications and Positive/Negative contrast of MRI

Cited by 16 publications

References 53 publications

Enhanced specific loss power of hematite–chitosan nanohybrid synthesized by hydrothermal method

Enhanced specific loss power of hematite–chitosan nanohybrid synthesized by hydrothermal method

Progeny Transfer Effects of Chitosan-Coated Cobalt Ferrite Nanoparticles

Surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells

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