Surface‐modified halloysite nanotubes reinforced poly(lactic acid) for use in biodegradable coronary stents

Chen, Yuan Yuan; Murphy, A. M.; Scholz, Dimitri; Geever, Luke M.; Lyons, John G.; Devine, Declan M.

doi:10.1002/app.46521

Cited by 20 publications

(15 citation statements)

References 39 publications

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“…While neat PLA was characterized by an E t value of 2086 MPa and the composite with 9 wt% HNTs was more brittle, with a tensile modulus of 2311 MPa (>10% increase). These results are in accordance to those reported by Chen et al [45]. This embrittlement could be related to an increase in the structural stiffness of PLA chains due to HNTs-PLA interactions [75,76].…”

Section: Resultssupporting

confidence: 92%

“…On the other hand, PLA is one of the most widely used material employed for fused deposition modeling (FDM) for 3D printed parts for whatever industry [38,39,40,41]. In addition to its biodegradability, PLA is resorbable and therefore it finds increasing use in the medicine industry (stents, screws, fixation plates, scaffolds for tissue engineering, surgical suture and so on) [42,43,44,45,46]. In these applications, PLA could also act as a drug carrier to provide controlled drug release [47,48].…”

Section: Introductionmentioning

confidence: 99%

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Manufacturing and Characterization of Functionalized Aliphatic Polyester from Poly(lactic acid) with Halloysite Nanotubes

et al. 2019

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This work reports the potential of poly(lactic acid)—PLA composites with different halloysite nanotube (HNTs) loading (3, 6 and 9 wt%) for further uses in advanced applications as HNTs could be used as carriers for active compounds for medicine, packaging and other sectors. This work focuses on the effect of HNTs on mechanical, thermal, thermomechanical and degradation of PLA composites with HNTs. These composites can be manufactured by conventional extrusion-compounding followed by injection molding. The obtained results indicate a slight decrease in tensile and flexural strength as well as in elongation at break, both properties related to material cohesion. On the contrary, the stiffness increases with the HNTs content. The tensile strength and modulus change from 64.6 MPa/2.1 GPa (neat PLA) to 57.7/2.3 GPa MPa for the composite with 9 wt% HNTs. The elongation at break decreases from 6.1% (neat PLA) down to a half for composites with 9 wt% HNTs. Regarding flexural properties, the flexural strength and modulus change from 116.1 MPa and 3.6 GPa respectively for neat PLA to values of 107.6 MPa and 3.9 GPa for the composite with 9 wt% HNTs. HNTs do not affect the glass transition temperature with invariable values of about 64 °C, or the melt peak temperature, while they move the cold crystallization process towards lower values, from 112.4 °C for neat PLA down to 105.4 °C for the composite containing 9 wt% HNTs. The water uptake has been assessed to study the influence of HNTs on the water saturation. HNTs contribute to increased hydrophilicity with a change in the asymptotic water uptake from 0.95% (neat PLA) up to 1.67% (PLA with 9 wt % HNTs) and the effect of HNTs on disintegration in controlled compost soil has been carried out to see the influence of HNTs on this process, which is a slight delay on it. These PLA-HNT composites show good balanced properties and could represent an interesting solution to develop active materials.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Manufacturing and Characterization of Functionalized Aliphatic Polyester from Poly(lactic acid) with Halloysite Nanotubes

et al. 2019

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“…The cold crystallisation temperature exhibited a significant decrease when the ASP was preloaded into the lumen of the HNT at a 2:1 ratio when compared to other batches of the nanocomposites. A reduction in Tcc of PLA/ASP-HNTs composites has been reported to be indicative of heterogeneous nucleation, where thinner or less perfect crystalline lamella are formed [8,47]. This is further supported by the twin melting peak of the nanocomposite, which is indicative of the melting of imperfect crystalline segments.…”

Section: Discussionmentioning

confidence: 95%

“…Polylactic acid (PLA) is the most widely used biodegradable aliphatic polymer as it is obtained from renewable resources such as corn and rice starch [7,8]. PLA is approved by the FDA for direct contact with biological fluids as it is biocompatible and its degradation products are nontoxic [9,10].…”

Section: Introductionmentioning

confidence: 99%

Faster Release of Lumen-Loaded Drugs than Matrix-Loaded Equivalent in Polylactic Acid/Halloysite Nanotubes

et al. 2019

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Nanocomposite-based drug delivery systems with intrinsic controlled release properties are of great interest in biomedical applications. We report a novel polylactic acid (PLA)/halloysite nanotube (HNT) nanocomposite-based drug delivery system. PLA/HNT nanocomposites have shown immense potential for use in biomedical applications due to their favorable cyto- and hemo-compatibility. The objective of this study was to evaluate the release of active pharmaceutical ingredients (API) from PLA/HNT composites matrix and the effect of preloading the API into the lumen of the HNT on its release profile. Aspirin was used in this study as a model drug as it is a common nonsteroidal anti-inflammatory and antiplatelet agent widely used for various medical conditions. These two types of drug-loaded PLA/HNT nanocomposites were characterised by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), surface wettability and mechanical testing. Statistical analysis was conducted on numerical data. Drug entrapment and in vitro drug release studies were conducted using UV spectrophotometry. Results indicate that aspirin was successfully loaded into the lumen of HNT, which resulted in the sustained release of aspirin from the nanocomposites. Furthermore, the addition of HNT into the polymer matrix increased the mechanical properties, indicating its suitability as a drug-eluting reinforcing agent.

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“…This antimicrobial ability makes chitosan a suitable candidate for implant coatings, wound dressing, and drug delivery applications, but chitosan has a major flaw which is its inherent mechanical weakness [8,9,10]. Many approaches, such as the addition of various polymers, [11,12] carbon nanotubes, [13,14] or clay nanoparticles [15,16], have been studied as a means to improve chitosan’s mechanical properties, and these additives increased the roughness of the scaffold which enhaced cell attachment, proliferation and differentiation [17,18,19].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Halloysite Addition on the Material Properties of Chitosan–Halloysite Hydrogel Composites

Luo

Mills

2019

Gels

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Chitosan-based hydrogels are being widely used in biomedical applications due to their eco-friendly, biodegradable, and biocompatible properties, and their ability to mimic the extracellular matrix of many tissues. However, the application of chitosan hydrogels has been limited due to their inherent mechanical weakness. Halloysite nanotubes (HNTs) are naturally occurring aluminosilicate clay minerals and are widely used as a bulk filler to improve the performance characteristics of many polymeric materials. HNTs have also been shown to be a viable nanocontainer able to provide the sustained release of antibiotics, chemicals, and growth factors. This study’s objective was to develop a stable drug delivery chitosan/HNT nanocomposite hydrogel that is biocompatible, biodegradable, and provides sustained drug release. In this study, chitosan/HNTs hydrogels containing undoped or gentamicin-doped HNTs were combined in different wt./wt. ratios and cross-linked with tripolyphosphate. The effects of chitosan and HNTs concentration and combination ratios on the hydrogel surface morphology, degradability, and mechanical properties, as well as its drug release capability, were analyzed. The results clearly showed that the addition of HNTs improved chitosan mechanical properties, but only within a narrow range. The nanocomposite hydrogels provided a sustained pattern of drug release and inhibited bacterial growth, and the live/dead assay showed excellent cytocompatibility.

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Surface‐modified halloysite nanotubes reinforced poly(lactic acid) for use in biodegradable coronary stents

Cited by 20 publications

References 39 publications

Manufacturing and Characterization of Functionalized Aliphatic Polyester from Poly(lactic acid) with Halloysite Nanotubes

Manufacturing and Characterization of Functionalized Aliphatic Polyester from Poly(lactic acid) with Halloysite Nanotubes

Faster Release of Lumen-Loaded Drugs than Matrix-Loaded Equivalent in Polylactic Acid/Halloysite Nanotubes

The Effect of Halloysite Addition on the Material Properties of Chitosan–Halloysite Hydrogel Composites

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