Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation

Botella, Pablo; Abasolo, Ibane; Fernández, Yolanda; Muniesa, Carlos; Miranda, Sónia; Quesada, Manuel; Ruiz, Jorge L.M.; Schwartz, Simó; Corma, Avelino

doi:10.1016/j.jconrel.2011.06.039

Cited by 100 publications

(65 citation statements)

References 59 publications

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“…According to the carriers, activetargeting preparation can be divided into modified liposomes, micro-emulsions, microspheres and nanoparticles, etc. (Bromberg et al, 2003;Cheng et al, 2007;Homhuan et al, 2007;Bakowsky et al, 2008;Mccarron et al, 2008;Min et al, 2008;Cao et al, 2009;Shen et al, 2009;Werle et al, 2009;Weber, 2010;Botella et al, 2011;Devarajan & Ravichandran, 2011). Tian et al (2010) using the specific receptor-ligand combination principle on the surface of tumor cells, established a liver-targeted drug delivery carrier, which was composed of chitosan/poly(ethylene glycol)-glycyrrhetinic acid nanoparticles.…”

Section: Active-targeting Tcm Preparationmentioning

confidence: 99%

Application of traditional Chinese medicine preparation in targeting drug delivery system

Xing

Dong

et al. 2014

Drug Delivery

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(2015) Application of traditional Chinese medicine preparation in targeting drug delivery system, Drug Delivery, 22:3, 258-265, DOI: 10.3109/10717544.2014 AbstractTargeting drug system (TDS) or targeted drug delivery system (TDDS) is a new kind of drug delivery system which could make drug to be directly concentrated on the target site with high curative effects and low side-effects. As the quintessence of Chinese culture, traditional Chinese medicine (TCM) has a large advantage in many disease clinical treatments, especially in cancer, hypertension and many other intractable diseases owing to their low toxicity and side-effects relative to western medicine. This article reviews literatures on development of TCM-targeted preparations which were published in the past 10 years. TDS including active-targeting, passive-targeting and physical-chemical-targeting preparations were introduced through domestic and overseas literatures to reveal the unique advantages of TCM-targeting preparations in drug delivery system. In this article, we have reviewed some kinds of TCM-targeting preparations and indicated that great attention should be paid to the research on the TCM-targeting preparations.

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Section: Active-targeting Tcm Preparationmentioning

confidence: 99%

Application of traditional Chinese medicine preparation in targeting drug delivery system

Xing

Dong

et al. 2014

Drug Delivery

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“…Recientemente nuestro grupo ha presentado un nuevo sistema de difusión de CPT basado en nanopartículas amorfas de sílice en el que la liberación de la molécula terapéutica depende de la acción de esterasas intracelulares [137].…”

Section: Sistemas Dependientes De La Actividad Enzimáticaunclassified

“…Esquema de la incorporación de Gly-CPT·TFA a nanopartículas de sílice funcionalizadas con grupos carboxilo [137].…”

Section: Sistemas Dependientes De La Actividad Enzimáticaunclassified

“…ii) En segundo lugar, a la desnaturalización de proteínas y iii) a la alteración de la membrana celular. Estos efectos citotóxicos podrían mitigarse con la modificación de la superficie de las nanopartículas [137,142].…”

Section: C) Limitaciones Para Su Uso Terapéuticounclassified

“…La mayoría aparecen en el citoplasma y algunas cercanas al núcleo. Otros órganos como pulmones y bazo también acumulan una cantidad considerable de nanopartículas [137,148].…”

Section: C) Limitaciones Para Su Uso Terapéuticounclassified

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Materiales nanoestructurados biocompatibles basados en sílice. Preparación y aplicaciones en terapia anticancerígena.

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Biotolerability of Intracortical Microelectrodes

Fernández

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2017

Adv. Biosys.

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The major prerequisite for the clinical application of intracortical microelectrodes, or any other neural implant, is that the organism accepts them without causing an unacceptable degree of harm. However, all biomaterials, even those thought to be highly biocompatible, provoke a biological response and some degree of encapsulation. This means that the body can tolerate them, although they are not fully compatible. Therefore, a significant goal is to improve the knowledge and understanding of the interaction between the implanted devices and the local cellular environment in order to improve the long‐term biotolerability, applicability, and functional perspectives of intracortical microelectrode arrays. In this article, some of the main challenges in this field that involves biomaterials science, bioengineering, neurology, neurosurgery, and neuroscience research are discussed.

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Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation

Cited by 100 publications

References 59 publications

Application of traditional Chinese medicine preparation in targeting drug delivery system

Application of traditional Chinese medicine preparation in targeting drug delivery system

Materiales nanoestructurados biocompatibles basados en sílice. Preparación y aplicaciones en terapia anticancerígena.

Biotolerability of Intracortical Microelectrodes

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