Surface-modified silk hydrogel containing hydroxyapatite nanoparticle with hyaluronic acid–dopamine conjugate

Kim, Hyung Hwan; Park, Jong Bo; Kang, Min Ji; Park, Young Hwan

doi:10.1016/j.ijbiomac.2014.06.052

Cited by 53 publications

(18 citation statements)

References 31 publications

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“…With a time sweep of 1-1000 s chosen to exhibit the gelation process, G′ and G″ data were collected. [28,29] The test temperature was 37°C. The diameter of the plate was 20 mm and the angle of the cone was 1°.…”

Section: Rheological Measurementsmentioning

confidence: 99%

“…[6][7][8][9][10][11]29] Pure SF solution and SNS/SF compounds with different mixing times, in which the final SF concentration was 20 g/L and the concentration of SNS was 4 g/L, were observed. The cross-sections were coated with platinum for 90 s and their morphologies were observed by Table SEM (TM 3030, Hitachi, Tokyo, Japan).…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

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Potential of biocompatible regenerated silk fibroin/sodium N-lauroyl sarcosinate hydrogels

Fang

Zhu

et al. 2015

Journal of Biomaterials Science, Polymer Edition

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Hydrogels are becoming widely used in biomaterial applications. The available methods for the preparation of these materials are continually growing. The gelation time (GT) of silk protein fibroin is difficult to control by physical methods. The cross-linkers used in available chemical techniques are likely to impact the biocompatibility of the resultant materials. In this paper, we demonstrate that the addition of sodium N-lauroyl sarcosinate (an amino-acid-based surfactant) accelerates the formation of hydrogels from fibroin. GT, turbidity variations, changes of viscoelasticity during the gelation process, and the mechanical properties of the products are measured. The secondary structure was probed by Fourier transform infrared spectroscopy, X-ray diffraction and the morphologies of the products were investigated by scanning electron microscopy. Transformations in the β-sheet content were monitored by the fluorescence of Thioflavine T and circular dichroism measurements. The relationship between the surface tension of sodium N-lauroyl sarcosinate and the GT was also explained. To investigate cell compatibility, fibroblast cells were seeded onto the surface of the hydrogels. The results indicate that the sodium N-lauroyl sarcosinate/fibroin GT can be controlled. This blend-hydrogel demonstrates excellent cell compatibility, good compression strength, and outstanding compression-recovery characteristics. Sodium N-lauroyl sarcosinate/silk fibroin hydrogels containing β-sheets have considerable potential as replacement materials in addressing the tissue defects involved with repair surgery.

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Section: Rheological Measurementsmentioning

confidence: 99%

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Potential of biocompatible regenerated silk fibroin/sodium N-lauroyl sarcosinate hydrogels

Fang

Zhu

et al. 2015

Journal of Biomaterials Science, Polymer Edition

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“…In recent years, much attention has been paid to the fabrication of functional scaffolds from natural polymers, such as collagen [5], gelatin [6], alginate [7], polylactic acid [8], polyamide [9], and silk fibroin (SF) [10][11][12][13][14][15][16], which can be incorporated together with HA to achieve both porosity and mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

In vitro bioactivity of glass-ceramic/fibroin composites

Radev

Michailova

Stateva

et al. 2017

PAC

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Bioactive composite materials were prepared by mixing 20 wt.% of silk fibroin (SF) and 80 wt.% of glassceramics from CaO-SiO 2-P 2 O 5-MgO system. In vitro bioactivity of the prepared composites was evaluated in 1.5 simulated body fluid (1.5 SBF) in static conditions. The obtained samples before and after in vitro tests were characterized by X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The changes in 1.5 SBF solutions after soaking the samples were evaluated by inductively coupled plasma atomic emission spectroscopy (ICP-AES). MG63 osteosarcoma cells were used for the biological experiments. The obtained experimental data proved that the synthesized composites exhibit excellent in vitro bioactivity.

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“…67 Similarly, a variety of gelatin-based hydrogels modified by nanoparticles have been developed. 68,69 For example, a composite hydrogel of photopolymerizable gelatin incorporating recombinant bone morphogenetic protein (BMP)-2 and sulfated chitosan nanoparticles was prepared and shown to have clear advantages for sustained and sequential delivery of growth factors (eg, BMP-2 and BMP-7). 68 Biodegradable gelatin hydrogel incorporating gold nanoparticles (average size 27±3 nm) was also studied.…”

mentioning

confidence: 99%

“…68,69 For example, a composite hydrogel of photopolymerizable gelatin incorporating recombinant bone morphogenetic protein (BMP)-2 and sulfated chitosan nanoparticles was prepared and shown to have clear advantages for sustained and sequential delivery of growth factors (eg, BMP-2 and BMP-7). 68 Biodegradable gelatin hydrogel incorporating gold nanoparticles (average size 27±3 nm) was also studied. 70 The results showed that these gel-gold nanoparticles were degradable with collagenase and promoted significant alkaline phosphatase activity, proliferation, viability, and osteogenic differentiation of stem cells.…”

mentioning

confidence: 99%

Nanotechnology for treating osteoporotic vertebral fractures

Gao¹,

Wei²,

Yang³

et al. 2015

IJN

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Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided.

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Surface-modified silk hydrogel containing hydroxyapatite nanoparticle with hyaluronic acid–dopamine conjugate

Cited by 53 publications

References 31 publications

Potential of biocompatible regenerated silk fibroin/sodium N-lauroyl sarcosinate hydrogels

Potential of biocompatible regenerated silk fibroin/sodium N-lauroyl sarcosinate hydrogels

In vitro bioactivity of glass-ceramic/fibroin composites

Nanotechnology for treating osteoporotic vertebral fractures

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