Surface molecular engineering of axial-exchanged Fe(III)Cl- and Mn(III)Cl-porphyrins towards enhanced electrocatalytic ORRs and OERs

Attatsi, Isaac Kwaku; Zhu, Weihua; Xu, Ling

doi:10.1016/j.ica.2020.119584

Cited by 7 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Singlet oxygen and other reactive oxygen species (ROS) can damage protein or cause the oxidation of intracellular thiols in bacteria, which could reduce the resistance of bacteria to drug [7]. Porphrins and boron-dipyrromethene uorophore (BODIPY) derivatives were reported as 1 O 2 generators for photodynamic therapy [8][9][10]. Photoactive Mn(II) complexes can be 1 O 2 generators for the cancer cell treatment by attenuating the cell energy metabolism [11].…”

Section: Introductionmentioning

confidence: 99%

A Photo-Responsive Porphyrin-Mn@Choles Complex for Bacteria Treatment

Wang

Chen

et al. 2021

J Inorg Organomet Polym

Self Cite

View full text Add to dashboard Cite

Biocompatible photo-driven producers of singlet oxygen can inhibit the growth of drug-resistant bacteria and tumors. In order to bacteria targeting generator of singlet oxygen for tumor and bacterial treatment, a metal porphyrin liposome (Phy-Mn-Ls) was prepared by the metal coordination reaction and selfassembly of porphyrin compounds with bacteria targeting polymer (HS-PEG-chol). The photo-driven production of 1 O 2 , binding with protein (BSA) and lipase, toxicity to MCF-7 breast cancer cells and inhibitory effect on the growth of Escherichia coli were investigated. Fluorescence analysis results show that Phy-Mn-Ls can bind to lipase, and it shows less effect on the conformation of BSA and is low cytotoxicity without irradiation. In particular, the good biocompatibility made Phy-Mn-Ls exhibit good photosensitive antibacterial activity and anti-tumor properties. The results demonstrate that the coordination of HS-PEG-chol with metal-phorphrin coodination is an effective way to develop bacteria targeting nano-complexes (Phy-Mn-Ls) for lipase a nity and photodriven bacteria treatment.

show abstract