Surface molecularly imprinted amino-functionalized alginate microspheres for enantio-selective extraction of l-ascorbic acid

Monier, M.; Shafik, Amira L.; Abdel-Latif, D.A.

doi:10.1016/j.carbpol.2018.04.106

Cited by 31 publications

(17 citation statements)

References 57 publications

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“…The most recent developments comprised the adaptation of this type of CSP to monoliths, nanoparticles, and predominantly to polymers. The introduction of different supports such as alginate microspheres [254] or polymer functionalized with quantum dots [255] were also reported as well as the description of different functional monomers and crosslinking agents [256,257,258,259].…”

Section: Chiral Stationary Phases: Recent Developmentsmentioning

confidence: 99%

Chiral Stationary Phases for Liquid Chromatography: Recent Developments

et al. 2019

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The planning and development of new chiral stationary phases (CSPs) for liquid chromatography (LC) are considered as continuous and evolutionary issues since the introduction of the first CSP in 1938. The main objectives of the development strategies were to attempt the improvement of the chromatographic enantioresolution performance of the CSPs as well as enlarge their versatility and range of applications. Additionally, the transition to ultra-high-performance LC were underscored. The most recent strategies have comprised the introduction of new chiral selectors, the use of new materials as chromatographic supports or the reduction of its particle size, and the application of different synthetic approaches for preparation of CSPs. This review gathered the most recent developments associated to the different types of CSPs providing an overview of the relevant advances that are arising on LC.

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Section: Chiral Stationary Phases: Recent Developmentsmentioning

confidence: 99%

Chiral Stationary Phases for Liquid Chromatography: Recent Developments

et al. 2019

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“…[9] Enantioselectivity in CMIPs may be achieved in three different ways: (i) by starting with a single enantiomer of the drug, (ii) by employing a chiral monomer, and (iii) by utilizing a cross-linker possessing chiral properties. [10][11][12] In order to resolve chiral problems, pure enantiomers can only be used if they are commercially available in sufficient amounts and at a reasonable price. It's both time-consuming and expensive to prepare chiral monomers and crosslinkers.…”

Section: Introductionmentioning

confidence: 99%

Construction of Amino‐Functionalized Molecularly Imprinted Silica Particles for (±)‐Ofloxacin Chiral Separation

Alatawi

2023

ChemistrySelect

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To enantioselectively separate a (�)-ofloxacin (OFX) racemic mixture, we describe the production and successful use of an S-ofloxacin (S-OFX) enantio-selective sorbent with amino functional groups. An amide derivative was first synthesized by reacting the S-OFX enantiomer with 3-aminopropyltriethoxysilane (S-OFX-Si-NH 2 ). The generated S-OFX-Si-NH 2 derivative was then mixed with tetraethoxysilane (TEOS) and put through a base-catalyzed sol-gel condensation polymerization process to insert the S-OFX enantiomeric species into the crosslinked material. To facilitate recombination involving S-OFX, an enantioselective gap is created by alkaline hydrolysis followed by acidification, freeing the S-OFX from the crosslinked matrix and filling the resulting gaps with cationic ions compatible with the S-OFX. Our chemical transformations of the monomeric precursor and the ensuing S-OFX molecularly imprinted material (S-OFX-Sil) were confirmed by elemental analysis, nuclear magnetic resonance (NMR), and Fourier transform infrared spectroscopy (FTIR). In addition, scanning electron microscopy images of the sorbent surface were employed to comprehend the morphological adjustments. Both the first loading run (60 % ee of R-OFX) and the second elution run (83 % ee of S-OFX) using the manufactured adsorbent particles showed promising separation results.

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“…MIPs have been developed in various application areas of biology and chemistry, such as in selective separation and sample preparation [ 9 , 10 , 11 , 12 ], nanocomposite materials [ 13 ], biological assays [ 14 , 15 , 16 ], catalysis [ 17 ], drug delivery [ 18 , 19 ], sensors [ 20 , 21 , 22 , 23 ], bioimaging and optical devices [ 24 ], food safety and environmental applications [ 25 , 26 ], enantioseparation [ 27 , 28 ], natural product extraction [ 29 , 30 ] and rare element purification [ 31 ]. MIPs can be obtained by various methods, including bulk polymerisation, precipitation polymerisation [ 32 , 33 ], suspension polymerisation, emulsion polymerisation, two-step swelling polymerisation [ 34 ], electropolymerisation [ 35 ], electrospinning [ 36 ], sol-gel imprinting [ 37 ] and phase inversion [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Microsphere Polymers in Molecular Imprinting: Current and Future Perspectives

et al. 2020

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Molecularly imprinted polymers (MIPs) are specific crosslinked polymers that exhibit binding sites for template molecules. MIPs have been developed in various application areas of biology and chemistry; however, MIPs have some problems, including an irregular material shape. In recent years, studies have been conducted to overcome this drawback, with the synthesis of uniform microsphere MIPs or molecularly imprinted microspheres (MIMs). The polymer microsphere is limited to a minimum size of 5 nm and a molecular weight of 10,000 Da. This review describes the methods used to produce MIMs, such as precipitation polymerisation, controlled/‘Living’ radical precipitation polymerisation (CRPP), Pickering emulsion polymerisation and suspension polymerisation. In addition, some green chemistry aspects and future perspectives will also be given.

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Surface molecularly imprinted amino-functionalized alginate microspheres for enantio-selective extraction of l-ascorbic acid

Cited by 31 publications

References 57 publications

Chiral Stationary Phases for Liquid Chromatography: Recent Developments

Chiral Stationary Phases for Liquid Chromatography: Recent Developments

Construction of Amino‐Functionalized Molecularly Imprinted Silica Particles for (±)‐Ofloxacin Chiral Separation

Microsphere Polymers in Molecular Imprinting: Current and Future Perspectives

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