Surface molecularly imprinted organic-inorganic polymers having affinity sites for cholesterol

Polyakova, I. V.; Боровикова, Л. Н.; Osipenko, A. A.; Vlasova, E. N.; Волчек, Б. З.; Писарев, О. А.

doi:10.1016/j.reactfunctpolym.2016.10.010

Cited by 31 publications

(13 citation statements)

References 44 publications

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“…MAA or HEMA were chosen as functional monomers responsible for hydrogen bonding between polymer material and a template. The possibility of using HEMA and EDMA as well as MAA and EDMA as monomers for the preparation of CHOL imprinted particles was previously shown . In our case, besides HEMA and MAA, BMA was also considered as a second functional monomer, which is able to provide hydrophobic interaction.…”

Section: Resultsmentioning

confidence: 73%

Cholesterol‐imprinted macroporous monoliths: Preparation and characterization

et al. 2017

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The development of sorbents for selective binding of cholesterol, which is a risk factor for cardiovascular disease, has a great importance for analytical science and medicine. In this work, two series of macroporous cholesterol-imprinted monolithic sorbents differing in the composition of functional monomers (methacrylic acid, butyl methacrylate, 2-hydroxyethyl methacrylate and ethylene dimethacrylate), amount of a template (4, 6 and 8 mol%) used for molecular imprinting, as well as mean pore size were synthesized by in situ free-radical process in stainless steel housing of 50 mm × 4.6 mm i.d. All prepared materials were characterized regarding to their hydrodynamic permeability and porous properties, as well as examined by BET and SEM methods. Imprinting factors, apparent dynamic dissociation constants, the maximum binding capacity, the number of theoretical plates and the height equivalent to a theoretical palate of MIP monoliths at different mobile phase flow rates were determined. The separation of a mixture of structural analogues, namely, cholesterol and prednisolone, was demonstrated. Additionally, the possibility of using the developed monoliths for cholesterol solid-phase extraction from simulated biological solution was shown.

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Section: Resultsmentioning

confidence: 73%

Cholesterol‐imprinted macroporous monoliths: Preparation and characterization

et al. 2017

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“…Polymer sorbents synthesized using nanoparticles were obtained by the free radical emulsion polymerization in Pickering emulsions [13], hereafter referred to as "Method 1" (MIP-1). A specific feature of this method of polymer synthesis was the use of Se 0 (NP-Se) nanoparticles stabilized with poly(vinylpyrrolidone) as stabilizers for polymer-monomer droplets.…”

Section: The Synthesis By Pickering Emulsion Polymerizationmentioning

confidence: 99%

“…The synthesis of polymers was carried out similarly to [13]: 2-HEMA and EGDMA were sequentially introduced into a colloidal system containing NP-Se/PVP nanocomplexes with constant stirring. In contrast to [13], the ratio of HEMA and EGDMA monomers was 86 mol.% and 14 mol.%, respectively.…”

Section: The Synthesis By Pickering Emulsion Polymerizationmentioning

confidence: 99%

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The Effect of the Synthesis Method on Physicochemical Properties of Selective Granular Polymer Sorbents

Osipenko

Garkushina

2022

Polymers

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Investigation of the effect of the polymer synthesis method on physicochemical properties of sorbents is one of the topical problems in the chemistry of macromolecular compounds that has high scientific and practical interest. Determination of the optimal synthesis method will make it possible to create sorbents with physicochemical properties that led to the realization of effective sorption. In this work, we investigated the effect of synthesis methods (Pickering emulsion polymerization and precipitation polymerization in solution) of granular polymers based on 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate on physicochemical and sorption properties. The synthesis by Pickering emulsion polymerization led to improvement of the n-propyl alcohol diffusion into the polymer network and to the formation of more homogeneous and structurally stable polymer networks. Creating selective polymer networks by Pickering emulsion polymerization compared to precipitation polymerization in solution led to an increase in porosity, creation of more segregated surface of granules, improvement of binding sites availability at the temperature of 37 °C, and formation of the homogeneous sorption surface with high affinity to target molecules at 25 °C and 37 °C. Selective polymers synthesized by both polymerization methods had the largest values of available sorption surfaces areas for target molecules at 37 °C.

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“…In the last few years, this technique has presented promising results in the preparation of specific groups of smart polymers with very high enantio‐selective properties that enable the separation of targeted specific enantiomers coexisting with their mirror images . Despite the advantages presented by the chiral molecularly imprinted polymers such as the inexpensive materials, thermal and mechanical stability as well as the ease of designing, manufacturing and the performance, the irregular distribution of asymmetric bonding cavities inside the polymer construction along with the possibility of distortion of these sites during the mechanical treatment of the polymers may reduce the separation efficiency of these polymeric materials …”

Section: Introductionmentioning

confidence: 99%

Surface molecular imprinting of nylon fibers for chiral recognition of d‐phenyllactic acid

Bukhari

Monier

Elsayed

2019

Polymer International

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In the current work, synthetic polyamide nylon fibers were modified via the strategy of surface molecular imprinting to develop enantio-selective adsorbent fabrics for chiral recognition of D-phenyllactic acid (D-PhLA). The nylon fibers were first modified by grafting of polyacrylamide and then the incorporated amide groups were converted into functional amino groups via treatment with NaOCl (Hofmann degradation). The amino-functionalized nylon fibers (Ny-NH 2 ) were interacted with the targeted D-PhLA enantiomer before crosslinking the amino-containing grafted chains with glutaraldehyde crosslinker followed by leashing the template D-PhLA out of the formed surface polymeric matrix by lowering the pH to 1 to finally produce the desired enantio-selective adsorbent fibers DP-Ny. Different instrumental methods such as elemental analysis, Fourier transform infrared spectroscopy, XRD and TGA were employed to examine all the synthetic procedures. SEM was also utilized to observe the morphological appearances of both native and modified nylon fibers. Moreover, the optimum extraction of D-PhLA was found to occur at pH 7. Isotherm studies of the prepared DP-Ny fibers obeyed the common Langmuir linear equation with q m values 130 ± 2 and 75 ± 1 mg g −1 in the case of D-PhLA and L-PhLA, respectively. Furthermore, the enantiomeric resolution of (±)-PhLA racemate was successfully carried out by a column technique with enantiomeric excess reaching approximately 78%.

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Surface molecularly imprinted organic-inorganic polymers having affinity sites for cholesterol

Cited by 31 publications

References 44 publications

Cholesterol‐imprinted macroporous monoliths: Preparation and characterization

Cholesterol‐imprinted macroporous monoliths: Preparation and characterization

The Effect of the Synthesis Method on Physicochemical Properties of Selective Granular Polymer Sorbents

Surface molecular imprinting of nylon fibers for chiral recognition of d‐phenyllactic acid

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