Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma

Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

show abstract

Section: Inorganic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The tumor‐targeting ability of Ti 3 C 2 @mMSNs was improved after modification by RGD. This nanocomposite showed high DOX loading capacity and pH‐ and NIR light‐responsive controllable release, which could effectively eradicate the tumor …”

Section: D Nanomaterials For Ptt‐based Synergistic Therapymentioning

confidence: 99%

Two‐Dimensional Nanomaterials for Photothermal Therapy

2020

View full text Add to dashboard Cite

Two‐dimensional (2D) nanomaterials are currently explored as novel photothermal agents because of their ultrathin structure, high specific surface area, and unique optoelectronic properties. In addition to single photothermal therapy (PTT), 2D nanomaterials have demonstrated significant potential in PTT‐based synergistic therapies. In this Minireview, we summarize the recent progress in 2D nanomaterials for enhanced photothermal cancer therapy over the last five years. Their unique optical properties, typical synthesis methods, and surface modification are also covered. Emphasis is placed on their PTT and PTT‐synergized chemotherapy, photodynamic therapy, and immunotherapy. The major challenges of 2D photothermal agents are addressed and the promising prospects are also presented.

show abstract

“…(F) Schematic illustration of pH/photothermal-triggered drug release from DOX-loaded Ti 3 C 2 @mMSNs-RGD [105]. (G) Cumulative DOX release from DOX-loaded Ti 3 C 2 @ mMSNs-RGD in phosphate-buffered saline (pH 7.4) as triggered by 808 nm NIR lasers at elevated power density [106].…”

Section: Chemotherapy and Pttmentioning

confidence: 99%

“…Because of its insensitivity to traditional systemic chemotherapy, new effective treatment strategies are urgently needed. Li et al reported a new 2D-MXene composite nanoplatform for high-efficiency synergistic chemotherapy and photothermal hyperthermia for liver cancer ( Figure 7G) [106]. The surface nanopore engineering method is used to realize the multifunctionality of Ti 3 C 2 -based MXene, and a thin layer of mesoporous silica is uniformly coated on the surface of 2D-MXenes.…”

Section: Chemotherapy and Pttmentioning

confidence: 99%

Two-dimensional metal carbides and nitrides (MXenes): preparation, property, and applications in cancer therapy

et al. 2020

View full text Add to dashboard Cite

Abstract Transition metal carbides and nitrides (MXenes), which comprise a rapidly growing family of two-dimensional materials, have attracted extensive attention of the scientific community, owing to its unique characteristics of high specific surface area, remarkable biocompatibility, and versatile applications. Exploring different methods to tune the size and morphology of MXenes plays a critical role in their practical applications. In recent years, MXenes have been demonstrated as promising nanomaterials for cancer therapy with substantial performances, which not only are helpful to clarify the mechanism between properties and morphologies but also bridge the gap between MXene nanotechnology and forward-looking applications. In this review, recent progress on the preparation and properties of MXenes are summarized. Further applications in cancer therapy are also discussed. Finally, the current opportunities and future perspective of MXenes are described.

show abstract

Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma

Cited by 204 publications

References 54 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Two‐Dimensional Nanomaterials for Photothermal Therapy

Two-dimensional metal carbides and nitrides (MXenes): preparation, property, and applications in cancer therapy

Contact Info

Product

Resources

About