Surface passivation by human albumin of plasmaperesis circuits reduces platelet accumulation and thrombus formation. Experimental and clinical studies

Mulvihill, J. N.; Faradji, A.; Oberling, F.; Cazenave, Jean‐Pierre

doi:10.1002/jbm.820240203

Cited by 77 publications

(39 citation statements)

References 12 publications

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“…One of the first proteins to be used for pre-coating blood-contacting surfaces was albumin [9]. Prior to the introduction of ionic or covalently bound surfaces, albumin was added to the circuit prime of adult circuits to increase the oncotic pressure of the priming solutions.…”

Section: Albuminmentioning

confidence: 99%

“…In pediatrics, it was often used as a precursor to the addition of packed red cells. The purpose of the albumin pre-coat was to provide a base layer of protein that would delay or mitigate the biological response to the heavily hydrophobic surfaces [9,10]. Adsorbed albumin both increases the hydrophilicity of the surface and provides a competitive protein that the fibrinogen must displace.…”

Section: Albuminmentioning

confidence: 99%

See 1 more Smart Citation

ECMO Biocompatibility: Surface Coatings, Anticoagulation, and Coagulation Monitoring

Maul¹,

Massicotte²,

Wearden³

2016

Extracorporeal Membrane Oxygenation: Advances in Therapy

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The interaction between the patient and the ECMO (extracorporeal membrane oxygenation) circuit initiates a significant coagulation and inflammatory response due to the large surface area of foreign material contained within the circuit. This response can be blunted with the appropriate mix of biocompatible materials and anticoagulation therapy. The use of anticoagulants, in turn, requires appropriate laboratory testing to determine whether the patient is appropriately anticoagulated. Physicians must balance the risks of bleeding with the risks of thrombosis; the proper interpretation of these tests is often shrouded in mystery. It is the purpose of this chapter to help demystify the coagulation system, anticoagulants, biocompatible surfaces, and coagulation testing so that ECMO practitioners can make informed decisions about their patients and to spur coordinated efforts for future research to improve our understanding of these complex processes.

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Section: Albuminmentioning

confidence: 99%

Section: Albuminmentioning

confidence: 99%

ECMO Biocompatibility: Surface Coatings, Anticoagulation, and Coagulation Monitoring

Maul¹,

Massicotte²,

Wearden³

2016

Extracorporeal Membrane Oxygenation: Advances in Therapy

View full text Add to dashboard Cite

show abstract

“…It is well documented that platelets do not adhere readily to such surfaces 34,41,42 ; therefore the albumin surfaces were employed as a negative control to study the possibility that the apparatus itself may cause significant platelet activation, thereby resulting in elevated adhesion to any surface, even one that is known to be unreactive. Platelet activation may be expected to result either from platelet interactions with the cone surface during the experiment or from local increases in shear rate as a result of fluid turbulence, for example in the peripheral regions of the cone-plate gap.…”

Section: Albumin-coated Surfacementioning

confidence: 99%

A cone-and-plate device for the investigation of platelet biomaterial interactions

Skarja

Kinlough-Rathbone

Perry

et al. 1997

J. Biomed. Mater. Res.

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A device based on the cone-and-plate flow geometry commonly employed for viscometry was developed for the investigation of cell-surface interactions. The cone-and-plate geometry is capable of generating uniform, constant shear-rate flow fields, and control of cone rotational speed allows for easy variation of fluid shear rate. The current design is adapted for use with any material that is available in the form of a flat plate (film or coating). It also allows for replicate samples (the same or different surfaces) to be evaluated simultaneously. The device was tested under varying flow conditions for its ability to measure platelet adhesion from suspensions of washed platelets containing red cells. Collagen- and albumin-coated polymer materials were used as "standard" surfaces of known platelet reactivity (high and low, respectively). Adhesion to the collagen-coated surface was measured over a range of shear rate from 0 to 300 s(-1) and times up to 15 min. Platelet adhesion was observed to increase with increasing shear rate and time. Adhesion was significantly higher in the presence of red cells as has been observed by others. Effective platelet diffusion coefficients, calculated from the data on adhesion to the collagen surface, increased with increasing shear rate. Very little platelet adhesion to the albumin-coated surface, known to be unreactive to platelets, was observed when measured over a 15 min time period at 300 s(-1) shear rate, indicating that the device itself does not stimulate the platelets in the flow field. The data generated provide validation for this device as a simple means of measuring cell adhesion under controlled flow conditions to any smooth surface available in flat plate form.

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“…A number of methods for preventing catheter clogging in the lumen have been proposed, including the use of large-lumen 10 and bearing biocompatibility of surface. 11 Heparin has been used to modify the polymeric surfaces of medical devices because it is a potent anticoagulant that interacts strongly with antithrombin III to prevent fibrin clot formation. 12 Two general methods have been used to prevent clogging formation on surfaces of polymeric materials using heparin.…”

Section: Introductionmentioning

confidence: 99%

Heparin derivatives coated drainage catheter for inhibition of thrombus formation

Moon¹,

Jeon²,

Lee

et al. 2011

Macromol. Res.

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A problem frequently encountered in the use of drainage catheters is that thrombus deposition tends to clog the drainage catheters, which destroy the efficacy of the device. In this study, a new heparin-releasing drainage catheter for inhibition of thrombus formation was proposed. The heparin-deoxycholic acid (heparin-DOCA) conjugate in the polyurethane solution was introduced to the drainage catheters using a simple casting method. From the results, the internal thickness of the coated drainage catheter was 15 µm and the coated surface of the catheter was even without defects. The pressures of the coated catheter measured at 7, 10, and 14 days were 10.8 ± 6.08, 25.0 ± 9.17, and 29.5 ± 12.02 mmHg, respectively. These values are relatively lower than the value of the bare catheter, showing that the pressure value of the bare catheter at 14 days was 198.5 ± 16.25 mmHg. This can be explained by the fact that the heparin-DOCA was released effectively from the catheter more than 2 weeks after inserting the catheter, which prevented thrombus deposition or fibrin clotting. In conclusion, the heparin release system is more effective for inhibiting thrombus formation than heparin-immobilized system.

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Surface passivation by human albumin of plasmaperesis circuits reduces platelet accumulation and thrombus formation. Experimental and clinical studies

Cited by 77 publications

References 12 publications

ECMO Biocompatibility: Surface Coatings, Anticoagulation, and Coagulation Monitoring

ECMO Biocompatibility: Surface Coatings, Anticoagulation, and Coagulation Monitoring

A cone-and-plate device for the investigation of platelet biomaterial interactions

Heparin derivatives coated drainage catheter for inhibition of thrombus formation

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