Surface Passivation of Carbon Nanoparticles with Branched Macromolecules Influences Near Infrared Bioimaging

Wu, Linzhi; Luderer, Micah; Yang, Xiaoxia; Swain, Corban; Zhang, Huiying; Nelson, Katherine S.; Stacy, Allen J.; Shen, Baogen; Lanza, Gregory M.; Pan, Dipanjan

doi:10.7150/thno.6535

Cited by 85 publications

(65 citation statements)

References 34 publications

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“…The average values of the zeta potential of C-dots were À19.4 mV and these results are in agreement with a previous experiment reporting a value of À20 mV. 41 On the other hand, the zeta potential of Ga@C-dots is +21 mV. The positive zeta potential is also an indication that metallic Ga or Ga 3+ ions are doped in or are on the surface of C-dots.…”

Section: Surface Charge Analysissupporting

confidence: 92%

The sonochemical synthesis of Ga@C-dots particles

et al. 2015

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This research article is focused on a one-step sonochemical fabrication of carbon dots (C-dots) doped with Ga atom (Ga@C-dots). The synthesis is carried out by sonicating in molten Ga, polyethylene glycol (PEG-400) as the reaction medium for 30-120 min. The produced Ga@C-dots is present in the PEG supernatant and has an average diameter of 5 AE 2 nm. Herein, fluorescence is used to probe the emission of Ga@C-dots and to examine if it differs from that of pristine C-dots. The new product was also characterized by fluorimetric, surface charge potential, and XPS (X-ray photoelectron spectroscopy) measurements. It was revealed that the physical properties of the Ga@C-dots are different from pristine C-dots. We attribute the fluorescence spectrum to energy transfer from the C-dots to the Ga particles.Ga@C-dots show high photosensitization with respect to pristine C-dots.

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Section: Surface Charge Analysissupporting

confidence: 92%

The sonochemical synthesis of Ga@C-dots particles

et al. 2015

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“…In this study, we chose mouse fetuses with different p53 genetic backgrounds as a model system, to evaluate potential differences in fetotoxic effects of the nanotubes. Our findings suggest that genetic background may be a major determinant of the toxicity of nanomaterials in exposed individuals, which will be very valuable in our future design of nano-carbons for bio-analysis, early diagnosis, drug/gene delivery and therapeutics [1, 57–64]. …”

Section: Discussionmentioning

confidence: 99%

The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development

et al. 2014

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In many cases cancer is caused by gene deficiency that is being passed along from generation to generation. Soluble carbon nanotubes (CNTs) have shown promising applications in the diagnosis and therapy of cancer, however, the potential relationship between cancer-prone individuals and response to CNT exposure as a prerequisite for development of personalized nanomedicine, is still poorly understood. Here we report that intravenous injections of multi-walled carbon nanotubes into p53 (a well-known cancer susceptible gene) heterozygous pregnant mice can induce p53- dependent responses in fetal development. Larger sized multi-walled carbon nanotubes moved across the blood-placenta barrier (BPB), restricted the development of fetuses, and induced brain deformity, whereas single-walled and smaller sized multi-walled carbon nanotubes showed no or less fetotoxicity. A molecular mechanism study found that multi-walled carbon nanotubes directly triggered p53-dependent apoptosis and cell cycle arrest in response to DNA damage. Based on the molecular mechanism, we also incorporated N-acetylcysteine (NAC), a FDA approved antioxidant, to prevent CNTs induced nuclear DNA damage and reduce brain development abnormalities. Our findings suggest that CNTs might have genetic background-dependent toxic effect on the normal development of the embryo, and provide new insights into protection against nanoparticle-induced toxicity in potential clinical applications.

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“…The peak around 280 nm can be attributed to the n– π * transition of the C=O band and the π – π * transition of the conjugated C=C band. [34] CB6 did not show any UV–vis signature peak due to the lack of chromophoric units. Niclosamide, demonstrated a pH-dependent absorption spectrum as shown in Figure 5A (inset).…”

Section: Resultsmentioning

confidence: 99%

Defined Host–Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer

Ostadhossein

Misra

Mukherjee

et al. 2016

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Signal transducer and activator of transcription factor 3 (STAT-3) is known to be overexpressed in cancer stem cells. Poor solubility and variable drug absorption are linked to low bioavailability and decreased efficacy. Many of the drugs regulating STAT-3 expression lack aqueous solubility; hence hindering efficient bioavailability. A theranostics nanoplatform based on luminescent carbon particles decorated with cucurbit[6]uril is introduced for enhancing the solubility of niclosamide, a STAT-3 inhibitor. The host–guest chemistry between cucurbit[6]uril and niclosamide makes the delivery of the hydrophobic drug feasible while carbon nanoparticles enhance cellular internalization. Extensive physicochemical characterizations confirm successful synthesis. Subsequently, the host–guest chemistry of niclosamide and cucurbit[6]uril is studied experimentally and computationally. In vitro assessments in human breast cancer cells indicate approximately twofold enhancement in IC50 of drug. Fourier transform infrared and fluorescence imaging demonstrate efficient cellular internalization. Furthermore, the catalytic biodegradation of the nanoplatforms occur upon exposure to human myeloperoxidase in short time. In vivo studies on athymic mice with MCF-7 xenograft indicate the size of tumor in the treatment group is half of the controls after 40 d. Immunohistochemistry corroborates the downregulation of STAT-3 phosphorylation. Overall, the host–guest chemistry on nanocarbon acts as a novel arsenal for STAT-3 inhibition.

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Surface Passivation of Carbon Nanoparticles with Branched Macromolecules Influences Near Infrared Bioimaging

Cited by 85 publications

References 34 publications

The sonochemical synthesis of Ga@C-dots particles

The sonochemical synthesis of Ga@C-dots particles

The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development

Defined Host–Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer

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