Surface Permeability of Membrane and Catalytic Performance Based on Redox-Responsive of Hybrid Hollow Polymeric Microcapsules

Abstract

“Smart” polymeric microcapsules with excellent permeability of membranes have drawn considerable attention in scientific and industrial research such as drug delivery carriers, microreactors, and artificial organelles. In this work, hybrid hollow polymeric microcapsules (HPs) containing redox-active gold-sulfide bond were prepared with bovine serum albumin, inorganic metal cluster (AuNCs), and poly(N-isopropylacrylamide) conjugates by using Pickering emulsion method. HPs were transferred from water-in-oil to water-in-water by adding PEGbis(N-succinimidylsuccinate). To achieve redox-responsive membrane, the Au-S bond units incorporated into the microcapsules’ membranes, allowed us to explore the effects of a new stimuli, that is, the redox Au-S bond breaking on the microcapsules’ membranes. The permeability of these hybrid hollow polymeric microcapsules could be sensitively tuned via adding environment-friendly hydrogen peroxide (H2O2), resulting from a fast fracture of Au-S bond. Meanwhile, AuNCs and conjugates could depart from the microcapsules, and enhance the permeability of the membrane. Based on the excellent permeability of the membrane, phosphatase was encapsuled into HPs and p-nitrophenyl phosphate as a substrate. After adding 1 × 10−2 and 1 × 10−4 M H2O2, the catalytic efficiency was nearly 4.06 and 2.22 times higher than that of HPs in the absence of H2O2, respectively. Hence, the unique redox-responsive HPs have potential applications in biocatalytic reaction, drug delivery, and materials as well as in bioscience.

Efficient Enzyme‐Metal Hybrid Catalysts Constructed with Polymer

“…Another example given by Wu and co-workers reported an ALP-AuNC-PNIPAAm hybrid catalyst. [20] The shell of ALP-AuNC-PNIPAAm consisted of a flexible ultrathin membrane that was structurally robust even dried under the environment of vacuum. The EMHCs were in the form of water-in-oil emulsion, and can be transferred to water-in-water by adding PEGbis(Nsuccinimidylsuccinate) that could react with the free primary amine groups of enzyme on the surface of the hybrid catalyst.…”

“…The activity of ALP‐AgNCs‐PNIPAAm nanohybrids increases as the membrane permeability increases, which may due to the enhancement in mass transfer. Another example given by Wu and co‐workers reported an ALP‐AuNC‐ PNIPAAm hybrid catalyst [20] . The shell of ALP‐AuNC‐PNIPAAm consisted of a flexible ultrathin membrane that was structurally robust even dried under the environment of vacuum.…”

Efficient construction of multi‐stimuli responsive colloidosomes for intelligent transmembrane transport

“…Stimulus is a common and effective means of regulating the properties of microcapsules. [37][38][39] To date, various stimuli used in applications include not only pH, [40][41][42][43] temperature, [44][45][46] and exposure to oxidation 47,48 but also light, [49][50][51] magnetism, 52,53 and ultrasound, [54][55][56] which can be used to remotely control the behavior of microcapsules from outside the system. Several stimulus-responsive colloidosomes have been successfully developed for the regulation of shell permeability.…”