Surface Plasmon Resonance Chemical Sensing on Cell Phones

Preechaburana, Pakorn; Gonzalez, Marcos Collado; Suska, Anke; Filippini, Daniel

doi:10.1002/anie.201206804

Cited by 184 publications

(91 citation statements)

References 23 publications

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“…The ultimate bulk detection limits are on the order of 10 −7 RIU [59], with surface binding concentrations of ng/cm 2 readily achievable [276]. New technologies, such as the cell-phone-based surface plasmon biosensor [277] are continually being advanced, indicating the relative ease of incorporating SPR sensors into "real world" devices. In 2008, Anker et al [278] accurately predicted the three key areas for advancing SPR technologies: (i) single-molecule detection, (ii) combining localized SPR with other sensor techniques to enhance the sensitivity and detection limits, and (iii) the development of practical sensors.…”

Section: Optical Methodsmentioning

confidence: 99%

“…In 2008, Anker et al [278] accurately predicted the three key areas for advancing SPR technologies: (i) single-molecule detection, (ii) combining localized SPR with other sensor techniques to enhance the sensitivity and detection limits, and (iii) the development of practical sensors. The development of devices that work with a common cell-phone represent excellent examples of point (iii) [277,279]. With respect to point (i), detection of as few as 20-100 streptavidin molecules was recently demonstrated on an LSPR array [280].…”

Section: Optical Methodsmentioning

confidence: 99%

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Whispering Gallery Mode Devices for Sensing and Biosensing

François¹,

Zhi

Meldrum

2015

Photonic Materials for Sensing, Biosensing and Display Devices

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Optical sensors based on resonant whispering gallery mode (WGM) optical cavities are discussed in the context of recent research developments. WGM-based sensors are among the most sensitive optical sensing devices currently known, especially when combined with surface plasmon effects. The basic theory of WGM "reactive" sensing is first discussed, along with the basic parameters that are used to characterize such devices (i.e., sensitivity, signal-to-noise ratio, and detection limit). Surface chemistry methods are of critical importance for targeted sensing applications and the fundamentals of this aspect are examined. The performance of fluorescent WGM-based devices is compared to state-of-the-art "evanescently-coupled" structures. Finally, the performance of WGM-based optical sensors is compared and contrasted to a range of alternative optical microsensor technologies currently under development.A. François

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Section: Optical Methodsmentioning

confidence: 99%

Section: Optical Methodsmentioning

confidence: 99%

Whispering Gallery Mode Devices for Sensing and Biosensing

François¹,

Zhi

Meldrum

2015

Photonic Materials for Sensing, Biosensing and Display Devices

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“…They have recently shown that with a designed sample cell and optics, it is possible to make SPR detection also with a cell phone. Most interestingly, it is possible to design the sample cell, so it can be used with a BIAcore sensing chip for (kinetic) evaluation of biomolecular interactions [60]. The sample cell, experimental setup, and results related to biosensing are shown in Figs.…”

Section: Spr Biosensing With a Cell Phonementioning

confidence: 99%

From a Laboratory Exercise for Students to a Pioneering Biosensing Technology

Lundström

2014

Plasmonics

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Surface plasmon resonance (SPR) for biosensing was demonstrated 30 years ago. In the present contribution, its general background is described together with the necessary developments both in instrumentation and surface chemistry, leading to the final so-called BIAcore technology. The description is naturally colored by my personal opinion of the developments. SPR for the elucidation of organic mono- and multilayers introduced at the end of the 1970s formed the basis for the first biosensing demonstration of SPR in the beginning of the 1980s. It is pointed out how the need of an up-to-date laboratory exercise for the undergraduate students and the multidisciplinary environment at the Laboratory of Applied Physics at Linköping University led to this demonstration. The initial experiments are touched upon and the further developments at Pharmacia, which led to the BIAcore technology, are described in some details. Some of the present activities in Linköping related to optical biosensing with ubiquitous instrumentation are also described, including SPR detection with a computer screen and a web camera and most recently with a cellular phone.

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“…Effective integration of the two key technologies critically empowers MS 2 for many mobile sensing applications. Current applications of MS 2 cover detection of various environmental and health indicators such as pH (Lopez-Ruiz et al 2014), nitrite , heavy metal (Chen et al 2014b;Wang et al 2014), bacterial contamination (Hutchison et al 2015;San Park et al 2013;Zhu et al 2012), blood glucose (Chun et al 2014), proteins (Chan et al 2015;Lillehoj et al 2013;Preechaburana et al 2012;You et al 2013) and other pathogen-associated biomarkers (Fronczek et al 2014;Stemple et al 2014;Yeo et al 2016). Some complicated assays such as enzyme-linked immunosorbent assay (ELISA) (Chen et al 2014a;Wang et al 2011) and polymerase chain reaction (PCR) Liao et al 2016;Stedtfeld et al 2012) were successfully implemented with the MS 2 systems.…”

Section: Introductionmentioning

confidence: 99%

Mkit: A cell migration assay based on microfluidic device and smartphone

Yang

Peretz‐Soroka

et al. 2018

Biosensors and Bioelectronics

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Mobile sensing based on the integration of microfluidic device and smartphone, so-called MS 2 technology, has enabled many applications over recent years, and continues to stimulate growing interest in both research communities and industries. In particular, it has been envisioned that MS 2 technology can be developed for various cell functional assays to enable basic research and clinical applications. Toward this direction, in this paper, we describe the development of a MS 2 -based cell functional assay for testing cell migration (the M kit ). The system is constructed as an integrated test kit, which includes microfluidic chips, a smartphone-based imaging platform, the phone apps for image capturing and data analysis, and a set of reagent and accessories for performing the cell migration assay. We demonstrated that the M kit can effectively measure purified neutrophil and cancer cell chemotaxis. Furthermore, neutrophil chemotaxis can be tested from a drop of whole blood using the M kit with red blood cell (RBC) lysis. The effects of chemoattractant dose and gradient profile on neutrophil chemotaxis were also tested using the M kit . In addition to research applications, we demonstrated the effective use of the M kit for on-site test at the hospital and for testing clinical samples from chronic obstructive pulmonary disease patient. Thus, this developed M kit provides an easy and integrated experimental platform for cell migration related research and potential medical diagnostic applications.

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Surface Plasmon Resonance Chemical Sensing on Cell Phones

Cited by 184 publications

References 23 publications

Whispering Gallery Mode Devices for Sensing and Biosensing

Whispering Gallery Mode Devices for Sensing and Biosensing

From a Laboratory Exercise for Students to a Pioneering Biosensing Technology

Mkit: A cell migration assay based on microfluidic device and smartphone

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