Surface plasmon resonance interferometry for micro-array biosensing

Никитин, П. И.; Григоренко, А. Н.; Beloglazov, A.A.; Valeiko, M. V.; Савчук, A. Й.; Savchuk, Olesya; Steiner, Gerald; Kühne, Christian; Huebner, Angela; Salzer, Reiner

doi:10.1016/s0924-4247(00)00386-1

Cited by 129 publications

(69 citation statements)

References 6 publications

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“…Here, three approaches to phase-sensitive measurements are possible. In the first approach, called SPR interferometry, phase information is extracted from an interference pattern between the "signal" p-polarized beam, reflected from the SPR-supporting film, and the "reference" beam presented by either an additional p-polarized beam [14][15][16]23,[40][41][42][43] or the unaffected s-polarized component of the same beam [17,19,[44][45][46][47][48][49]. Such approach makes possible the extraction of a pure phase response in sensing or 2D imaging geometries.…”

Section: Surface Plasmon Resonance: Phase Vs Amplitudementioning

confidence: 99%

“…About 10 years ago, polarization contrast schemes had been proposed [71][72][73]42], and they were found to provide better performance than SPR imaging based on amplitude only [86]. In the polarization contrast scheme, polarizers and waveplates were incorporated into the conventional amplitude based SPR imaging geometry to create a low intensity background from an uncoated region of the glass surface.…”

Section: Polarimetrymentioning

confidence: 99%

“…In 2000, Nikitin's group demonstrated phase detection based SPR imaging with a spatial resolution of 50 × 50 µm [42]. However, due to the complexity for array flow cells fabrication, they only showed a gold chip with a micro-array self-assembled thiol monolayer and the detection of a sample fatty acid droplet.…”

Section: Array Sensing Of Dna and Proteinmentioning

confidence: 99%

See 2 more Smart Citations

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

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International audienceSurface Plasmon Resonance (SPR) has become a central tool for label-free characterization of biomolecular interactions. Based on monitoring of amplitude characteristics, conventional SPR sensors have been extensively explored, commercialized and applied for studies of many important interactions (antigen-antibody, protein-ligand etc), but this technology still lacks of sensitivity for the detection of relatively small and low copy number compounds. Phase-sensitive SPR has recently emerged as an upgrade of this technology to resolve the sensitivity issue. Profiting from a sharp phase jump under SPR and ultra-sensitive tools of its control, this technology offers up to 100-time improvement of the detection limit, giving access to the detection of trace amounts of small molecular weight analytes (drugs etc). This paper intends to provide a tutorial on basic concepts of phase detection in SPR sensing, compare the performance of phase- and amplitude-sensitive sensors, review recent progress in the development and applications of phase-sensitive SPR sensors, and outline future prospects and trends of this technology

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Section: Surface Plasmon Resonance: Phase Vs Amplitudementioning

confidence: 99%

Section: Polarimetrymentioning

confidence: 99%

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Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

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“…However, improvements are required in many areas, such as prevention of non-specific binding [302][303][304][305][306], sensitivity [307][308][309][310][311][312][313][314][315], site-specific conjugation [316][317][318], bioactivity [319][320][321][322], multiplexing [309,323], and reusability [324][325][326]. Some of these problems can be addressed by using different chemical surface modification approaches.…”

Section: Biosensing-detectionmentioning

confidence: 99%

Peptide-based biopolymers in biomedicine and biotechnology

Chow

Nunalee

Lim

et al. 2008

Materials Science and Engineering: R: Reports

286

231

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Peptides are emerging as a new class of biomaterials due to their unique chemical, physical, and biological properties. The development of peptide-based biomaterials is driven by the convergence of protein engineering and macromolecular self-assembly. This review covers the basic principles, applications, and prospects of peptide-based biomaterials. We focus on both chemically synthesized and genetically encoded peptides, including poly-amino acids, elastin-like polypeptides, silk-like polymers and other biopolymers based on repetitive peptide motifs. Applications of these engineered biomolecules in protein purification, controlled drug delivery, tissue engineering, and biosurface engineering are discussed.

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“…In this case, even a small increase of sensitivity can open a way to use SPR technology for a new class of substances. Last years, a number of attempts have been made to improve this technique, they include a polarization of the incident light beam [6,7], a waveguide propagation of light [8][9][10] or using of porous active phases or even nanocrystals and nanoparticles [11][12][13][14][15][16][17][18]. We suggest here a new way to increase a signal / noise ratio of SPR devices.…”

Section: Introductionmentioning

confidence: 99%

Bimetallic Layers Increase Sensitivity of Affinity Sensors Based on Surface Plasmon Resonance

Zynio

Samoylov

Surovtseva

et al. 2002

Sensors

212

112

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Abstract:Two metals are used in resonant layers for chemical sensors based on surface plasmon resonance (SPR) -gold and silver. Gold displays higher shift of the resonance angle to changes of ambient refraction index and is chemically stable. Silver posses narrower resonance curve thus providing a higher signal/noise ratio of SPR chemical sensors, but has a poor chemical stability. A new structure of resonant metallic film based on bimetallic silver/gold layers (gold as an outer layer) is suggested. It combines advantages of both gold and silver resonant layers. Bimetallic resonant films display so high shift of resonance angle on changes of ambient refraction index as gold films, but show narrower resonance curve, thus providing a higher signal / noise ratio. Additionally, the outer gold layer protects silver against oxidation.

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Surface plasmon resonance interferometry for micro-array biosensing

Cited by 129 publications

References 6 publications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Peptide-based biopolymers in biomedicine and biotechnology

Bimetallic Layers Increase Sensitivity of Affinity Sensors Based on Surface Plasmon Resonance

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