2011
DOI: 10.1021/ac200157p
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Surface Plasmon Resonance Phase Imaging Measurements of Patterned Monolayers and DNA Adsorption onto Microarrays

Abstract: The optical technique of surface plasmon resonance phase imaging (SPR-PI) is implemented in a linear microarray format for real-time measurements of surface bioaffinity adsorption processes. SPR-PI measures the phase shift of p-polarized light incident at the SPR angle reflected from a gold thin film in an ATR Kretschmann geometry by creating an interference fringe image on the interface with a polarizer-quartz wedge depolarizer combination. The position of the fringe pattern in this image changes upon the ads… Show more

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Cited by 75 publications
(46 citation statements)
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“…As shown in Figure 6a, we implemented a simple interferometric phase interrogation scheme based on the work of Halpern et al 29,30 The set-up is based on off-the-shelf optical components and a laser diode emitting at 639 nm, i.e., close to the reflection minimum of the nanoparticle layer. In brief, the collimated diode output is linearly polarized before passing through a double birefringent wedge prism that creates a spatially varying polarization state across the illuminated area The phase difference between p-and s-polarized light, D, calculated using the inversion of Equation (2) and the reflections in Figure 3.…”
Section: Refractometric Biosensing Using Phase Interrogationmentioning
confidence: 99%
“…As shown in Figure 6a, we implemented a simple interferometric phase interrogation scheme based on the work of Halpern et al 29,30 The set-up is based on off-the-shelf optical components and a laser diode emitting at 639 nm, i.e., close to the reflection minimum of the nanoparticle layer. In brief, the collimated diode output is linearly polarized before passing through a double birefringent wedge prism that creates a spatially varying polarization state across the illuminated area The phase difference between p-and s-polarized light, D, calculated using the inversion of Equation (2) and the reflections in Figure 3.…”
Section: Refractometric Biosensing Using Phase Interrogationmentioning
confidence: 99%
“…An interesting example of the first strategy is reported in Ref. [58], where the phase shift of p-polarized light interacting with surface plasmon was measured by creating an interference fringe image on the interface, which changed upon hybridization of DNA 30mers, yielding a LOD of 50 pg/ml ( Figure 5B). As for the second, localized SPR can instead be obtained with various types of patterning, like gold nanoprisms with 30-50 nm edges [68,59], which allowed miRNA quantitation with an impressive LOD as low as 0.25 fg/ml ( Figure 5C).…”
Section: Na In the Crosshairs: Label-free Detection Of Specific Sequementioning
confidence: 99%
“…Another example of nanostructured surfaces exploits the optical diffraction of arrays of nanowires (Fig. 3C) separated by micrometer distances that can be interrogated in total internal reflection-phase imaging [21] or transmission diffraction measurements [22]. These nanowires support a localized surface plasmon resonance (LSPR) mode that could be exploited in a biosensing assay [22].…”
Section: Enhancing Sensitivity With Nanostructured Substratesmentioning
confidence: 99%