Surface Potential Analysis of Nanoscale Biomaterials and Devices Using Kelvin Probe Force Microscopy

Lee, Hyungbeen; Lee, Wonseok; Lee, Jeong Hoon; Yoon, Dae Sung

doi:10.1155/2016/4209130

Cited by 38 publications

(30 citation statements)

References 109 publications

(119 reference statements)

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“…Roughness is an important property of graft materials, owing to its strong influence on the adhesion, growth, proliferation, and osseointegration of osteoblast cells [ 18 ]. However, measuring the roughness of a granular graft material is a very difficult task, due to its waviness, which is associated with its shape and porosity.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical characterization of porcine bone-derived grafting material and comparison with bovine xenografts for dental applications

Lee

et al. 2017

J Periodontal Implant Sci

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PurposeThe physicochemical properties of a xenograft are very important because they strongly influence the bone regeneration capabilities of the graft material. Even though porcine xenografts have many advantages, only a few porcine xenografts are commercially available, and most of their physicochemical characteristics have yet to be reported. Thus, in this work we aimed to investigate the physicochemical characteristics of a porcine bone grafting material and compare them with those of 2 commercially available bovine xenografts to assess the potential of xenogenic porcine bone graft materials for dental applications.MethodsWe used various characterization techniques, such as scanning electron microscopy, the Brunauer-Emmett-Teller adsorption method, atomic force microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, and others, to compare the physicochemical properties of xenografts of different origins.ResultsThe porcine bone grafting material had relatively high porosity (78.4%) and a large average specific surface area (SSA; 69.9 m2/g), with high surface roughness (10-point average roughness, 4.47 µm) and sub-100-nm hydroxyapatite crystals on the surface. Moreover, this material presented a significant fraction of sub-100-nm pores, with negligible amounts of residual organic substances. Apart from some minor differences, the overall characteristics of the porcine bone grafting material were very similar to those of one of the bovine bone grafting material. However, many of these morphostructural properties were significantly different from the other bovine bone grafting material, which exhibited relatively smooth surface morphology with a porosity of 62.0% and an average SSA of 0.5 m2/g.ConclusionsConsidering that both bovine bone grafting materials have been successfully used in oral surgery applications in the last few decades, this work shows that the porcine-derived grafting material possesses most of the key physiochemical characteristics required for its application as a highly efficient xenograft material for bone replacement.

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Section: Resultsmentioning

confidence: 99%

Physicochemical characterization of porcine bone-derived grafting material and comparison with bovine xenografts for dental applications

Lee

et al. 2017

J Periodontal Implant Sci

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“…For precise measurement from the KPFM, we optimized the lift scan height and scan speed of the conductive cantilever tip on the KPFM based on previous work. [32][33][34][35] We measured both the high-resolution topology and SP images, as shown in Figure 2. Figures 2(c), 2(e), and 2(g) depict representative 3D topology and SP images of the bare MoS 2 surface.…”

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confidence: 99%

Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy

et al. 2016

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We used high-resolution Kelvin probe force microscopy (KPFM) to investigate the immobilization of a prostate specific antigen (PSA) antibody by measuring the surface potential (SP) on a MoS2 surface over an extensive concentration range (1 pg/ml–100 μg/ml). After PSA antibody immobilization, we demonstrated that the SP on the MoS2 surface characterized by KPFM strongly correlated to the electrical signal of a MoS2 bioFET. This demonstration can not only be used to optimize the immobilization conditions for captured molecules, but can also be applied as a diagnostic tool to complement the electrical detection of a MoS2 FET biosensor.

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“…Therefore, the interaction of DPSCs with PPG morsels was evaluated by SEM. The results revealed significant proliferation of DPSCs on the rough surface of PPG, indicating strong influence of the material surface morphology, porosity, and ion release on cell growth, proliferation, and adhesion [ 15 , 53 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Development and physicochemical characterization of novel porous phosphate glass bone graft substitute and in vitro comparison with xenograft

Chauhan

Lakhkar

Chaudhari

2021

J Mater Sci: Mater Med

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The process of bone regeneration in bone grafting procedures is greatly influenced by the physicochemical properties of the bone graft substitute. In this study, porous phosphate glass (PPG) morsels were developed and their physicochemical properties such as degradation, crystallinity, organic content, surface topography, particle size and porosity were evaluated using various analytical methods. The in vitro cytotoxicity of the PPG morsels was assessed and the interaction of the PPG morsels with Dental Pulp Stem Cells (DPSCs) was studied by measuring cell proliferation and cell penetration depth. The cell-material interactions between PPG morsels and a commercially available xenograft (XG) were compared. The PPG morsels were observed to be amorphous, biocompatible and highly porous (porosity = 58.45%). From in vitro experiments, PPG morsels were observed to be non-cytotoxic and showed better cell proliferation. The internal surface of PPG was easily accessible to the cells compared to XG.

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Surface Potential Analysis of Nanoscale Biomaterials and Devices Using Kelvin Probe Force Microscopy

Cited by 38 publications

References 109 publications

Physicochemical characterization of porcine bone-derived grafting material and comparison with bovine xenografts for dental applications

Physicochemical characterization of porcine bone-derived grafting material and comparison with bovine xenografts for dental applications

Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy

Development and physicochemical characterization of novel porous phosphate glass bone graft substitute and in vitro comparison with xenograft

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