Abstract. Let G be a complete Kac-Moody group of rank n ≥ 2 over the finite field of order q, with Weyl group W and building Δ. We first show that if W is right-angled, then for all q ≡ 1 (mod 4) the group G admits a cocompact lattice Γ which acts transitively on the chambers of Δ. We also obtain a cocompact lattice for q ≡ 1 (mod 4) in the case that Δ is Bourdon's building. As a corollary of our constructions, for certain rightangled W and certain q, the lattice Γ has a surface subgroup. Our second main result states that if W is a free product of spherical special subgroups, then for all q, the group G admits a cocompact lattice Γ, with Γ a finitely generated free group. Thus for many G of rank n ≥ 3, our results provide the first (explicit) constructions of cocompact lattices in G, and in particular, the first explicit examples of cocompact lattices in complete Kac-Moody groups whose Weyl group is not right-angled. Our proofs use generalizations of our results in rank 2 [5] concerning the action of certain finite subgroups of G on Δ, together with covering theory for complexes of groups.