A symmetrical 2-thiopyrimidine based molecule with an expanded p-electron system is synthesized and used to form a self-assembled monolayer (SAM) on gold surfaces. Utilizing chemical vapor deposition a monolayer of (3-mercaptopropyl)triethoxysilane is formed on silicon dioxide substrates. Both of these SAM coated substrates are characterized by Xray photoelectron spectroscopy and the growth of a coordination polymer built up from 5,5 0 -(ethyne-1,2-diyl)bis(2-hydroxyacetophenone) and copper(II) on dual SAM coated transducers is studied. After the deposition procedure on interdigital elec-trodes the electrical properties of the polymer are investigated performing resistive measurements. A significant change of the resistance, which depends on the surrounding atmosphere, proves the sensing behavior of the synthesized coordination polymer.