The performance of superconducting radio-frequency (SRF) cavities made of bulk Nb at high fields (peak surface magnetic field greater than about 90 mT) is characterized by exponentially increasing rf losses (high-field Q slope), in the absence of field emission, which are often mitigated by low-temperature (100-140 C, 12-48 h) baking. In this contribution, recent experimental results and phenomenological models to explain this effect will be briefly reviewed. New experimental results on the high-field Q slope will be presented for cavities that had been heat treated in a vacuum furnace at high temperature without subsequent chemical etching. These studies are aimed at understanding the role of hydrogen on the highfield Q slope and at the passivation of the Nb surface during heat treatment. Improvement of the cavity performances, particularly of the cavities' quality factor, have been obtained following the hightemperature heat treatments, while secondary ion mass spectroscopy surface analysis measurements on Nb samples treated with the cavities revealed significantly lower hydrogen concentration than for samples that followed standard cavity treatments.