Surface topographical and ultrastructural alterations of Raillietina echinobothrida and Ascaridia galli induced by a compound isolated from Acacia oxyphylla

Roy, Bishnupada; Dasgupta, Shyamashree; Manivel, Venkatasamy; Parameswaran, P.S.; Giri, Bikash Ranjan

doi:10.1016/j.vetpar.2011.09.041

Cited by 25 publications

(23 citation statements)

References 10 publications

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“…Traditional medicine relies on using natural products for the treatment of both veterinary and human helminths (Hammond et al 1997;Roy et al 2012;Dhakal et al 2015). The family Zingiberaceae contains three genera (Zingiber officinale, Curcuma longa L., and Elettaria cardamomum (Daoud 2008).…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic activity of ginger, curcumin, and praziquentel against Raillietina cesticillus (in vitro and in vivo)

Elbahy

Bazh

2015

Parasitol Res

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This work evaluates the anthelminitic activity of ginger and curcumin on the cestode Raillietina cesticillus. Live parasites were collected from intestine of naturally infected chickens in PBS 0.9 % and then incubated at 37 °C in media containing ginger extract at three different concentrations (125, 250, and 500 mg); every concentration was dissolved in 10 ml media. The curcumin extract was used at three different concentrations (250, 500, and 1000 mg); each was dissolved in 10 ml media. Praziquantel at a concentration of 600 mg was added to 10 ml media. A control one without extract was reported. Regression of worms increased gradually in all concentrations. At 500 mg ginger (50 ± 0 %), worms were regressed at 48 h post-exposure (h.p.e.). Also (50 ± 1.8 %), worms were regressed at 1000 mg curcumin at the same time. On the other hand, praziquantel showed the highest regression (65 ± 2.3 %). The extract efficacy was exhibit as concentration-time-dependent mainly at higher concentrations used after 48 h. In vivo effects of ginger and curcumin were lower than those in vitro.

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Section: Introductionmentioning

confidence: 99%

Anthelmintic activity of ginger, curcumin, and praziquentel against Raillietina cesticillus (in vitro and in vivo)

Elbahy

Bazh

2015

Parasitol Res

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“…Berbagai jenis tumbuhan yang sering digunakan turun temurun sebagai obat tradisional oleh masyarakat telah banyak dibuktikan memiliki potensi daya bunuh terhadap cacing cestoda. Aktivitas ekstrak etanol kulit batang Acacia oxyphylla (Dasgupta et al, 2010;Roy et al, 2012), ekstrak etanol daun Lysimachia lamosa (Challam et al, 2010), dan Securinega virosa (Dasgupta et al, 2013), ekstrak akar tumbuhan Millettia pachycarpa (Roy et al, 2012;Giri et al, 2013), ekstrak metanol akar tumbuhan Potentilla fulgens, dan daun Alpinia nigra dapat merusak struktur morfologi cacing cestoda Raillietina echinobothrida.…”

Section: Traditional Medicine Journal 22(3) 2017unclassified

“…Ekstrak daun A. indica (Khokon et al, 2004;Saha et al, 2015), ekstrak Curcuma longa (Alrubaie, 2015), ekstrak etanol kulit buah jeruk (Abdelqader et al, 2012), ekstrak daun Bishkatali (Polygonum hydropiper) (Islam et al, 2008) mempercepat waktu paralisis dan mortalitas A. galli secara in vitro. Lalchhandama et al (2009) dan Roy et al (2012) …”

Section: Traditional Medicine Journal 22(3) 2017unclassified

“…Dasgupta et al (2010) menyatakan bahwa pemberian ekstrak etanol kulit batang A. oxyphylla dapat menyebabkan pengelupasan tegumen sampai ke dalam membran plasma, kehilangan organisasi seratserat otot, dan beberapa kerusakan pada sepanjang tegumen karena kehilangan organel seluler cacing R. echinobothrida. Roy et al (2012) menjelaskan bahwa pengamatan melalui scanning electron micrograph menunjukkan perubahan struktur dan topografi pada tegumen R. echinobothrida yang terjadi setelah efek paralisis karena aktivitas senyawa aktif yang diisolasi dari kulit batang A. oxyphylla. Tegumen R. echinobothrida mengalami disorganisasi seratserat otot, kehilangan kontak antar sel, vakuolisasi yang ekstrim, dan udema.…”

Section: Hasil Dan Pembahasanunclassified

“…Sel-sel telur cacing A. galli ditemukan masih bersegmentasi di dalam uterus, tidak ada sel-sel telur yang mengalami disintegrasi. Namun, Roy et al (2012) menyatakan bahwa dosis 25 mg/mL ekstrak akar tumbuhan M. pachycarpa Benth (Leguminosae) menyebabkan distorsi dan disrupsi mitokondria, inti, anak inti, membran inti, lamina basalis dan vacuolisasi tegumen R. echinobothrida secara in vitro. Giri et al (2013) menyatakan bahwa tumbuhan obat tradisional masyarakat bagian utara India memiliki aktivitas anthelmintik pada cacing cestoda, R. echinobothrida.…”

Section: Hasil Dan Pembahasanunclassified

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