Surface Tuning of Wood via Covalent Modification of Its Lignocellulosic Biopolymers with Substituted Benzoates─A Study on Reactivity, Efficiency, and Durability

Söftje, Martin; Weingartz, Thea; Plarre, Rudy; Gjikaj, Mimoza; Namyslo, Jan C.; Kaufmann, Dieter

doi:10.1021/acsomega.1c04353

Cited by 3 publications

(3 citation statements)

References 54 publications

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“…44,45 The chemical modification and synthesis of the cobiopolymer mixture can overcome the limitations. 46,47 In this study, keratin was modified chemically using reductants and a methacrylate group, called keratin methacrylate (KEMA), to become soluble in water and photocross-linkable.…”

Section: Introductionmentioning

confidence: 99%

“…For tissue engineering applications, fabricating an ideal scaffold with good mechanical and still maintaining biological properties is often challenging. , The chemical modification and synthesis of the cobiopolymer mixture can overcome the limitations. , In this study, keratin was modified chemically using reductants and a methacrylate group, called keratin methacrylate (KEMA), to become soluble in water and photo-cross-linkable.…”

Section: Introductionmentioning

confidence: 99%

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Design and Synthesis of Stem Cell-Laden Keratin/Glycol Chitosan Methacrylate Bioinks for 3D Bioprinting

et al. 2022

Biomacromolecules

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With the advancements in tissue engineering and three-dimensional (3D) bioprinting, physiologically relevant three-dimensional structures with suitable mechanical and bioactive properties that mimic the biological tissue can be designed and fabricated. However, the available bioinks are less than demanded. In this research, the readily available biomass sources, keratin and glycol chitosan, were selected to develop a UV-curable hydrogel that is feasible for the 3D bioprinting process. Keratin methacrylate and glycol chitosan methacrylate were synthesized, and a hybrid bioink was created by combining this protein–polysaccharide cross-linked hydrogel. While human hair keratin could provide biological functions, the other composition, glycol chitosan, could further enhance the mechanical strength of the construct. The mechanical properties, degradation profile, swelling behavior, cell viability, and proliferation were investigated with various ratios of keratin methacrylate to glycol chitosan methacrylate. The composition of 2% (w/v) keratin methacrylate and 2% (w/v) chitosan methacrylate showed a significantly higher cell number and swelling percentage than other compositions and was designated as the bioink for 3D printing afterward. The feasibility of stem cell loading in the selected formula was examined with an extrusion-based bioprinter. The cells and spheroids can be successfully printed with the synthesized bioink into a specific shape and cultured. This work provides a potential option for bioinks and delivers insights into personalization research on stem cell-laden biofabricated hydrogels in the future.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of Stem Cell-Laden Keratin/Glycol Chitosan Methacrylate Bioinks for 3D Bioprinting

et al. 2022

Biomacromolecules

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“…. 45 White colour solid, yield 0.119g (71%); Rf = 0.6 (5% ethyl acetate/n-hexane); 1 35 White crystalline Solid, yield 0.150g (95%); Rf = 0.5 (5% ethyl acetate/n-hexane); 1…”

Section: -(1h-benzo[d][123]triazole-1-carbonyl)benzonitrile (2s)mentioning

confidence: 99%

Synthesis of N-acylbenzotriazole using acid anhydride

singh¹,

Pandey²,

Prajapati³

et al. 2022

Arkivoc

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A novel approach has been adopted for the conversion of carboxylic acids into corresponding N-acyl benzotriazoles utilizing acid anhydride. Our trial has ascertained 2,2,2-trifluoroacetic anhydride in anhydrous dichloromethane as the best candidate to achieve the targeted goal. The reliable and reproducible outcomes of the developed method are easy handling, wide substrate scope, and one-pot high-yielding under mild reaction condition. Moreover, the elimination of external base usage makes this procedure of utmost advantage in Nacyl benzotriazole synthesis.

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Enhancing Cellulose and Lignin Fractionation from Acacia Wood: Optimized Parameters Using a Deep Eutectic Solvent System and Solvent Recovery

Magalhães,

Aliaño-González,

Rodrigues

et al. 2024

Molecules

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Cellulose and lignin, sourced from biomass, hold potential for innovative bioprocesses and biomaterials. However, traditional fractionation and purification methods often rely on harmful chemicals and high temperatures, making these processes both hazardous and costly. This study introduces a sustainable approach for fractionating acacia wood, focusing on both cellulose and lignin extraction using a deep eutectic solvent (DES) composed of choline chloride (ChCl) and levulinic acid (LA). A design of experiment was employed for the optimization of the most relevant fractionation parameters: time and temperature. In the case of the lignin, both parameters were found to be significant variables in the fractionation process (p-values of 0.0128 and 0.0319 for time and temperature, respectively), with a positive influence. Likewise, in the cellulose case, time and temperature also demonstrated a positive effect, with p-values of 0.0103 and 0.028, respectively. An optimization study was finally conducted to determine the maximum fractionation yield of lignin and cellulose. The optimized conditions were found to be 15% (w/v) of the wood sample in 1:3 ChCl:LA under a treatment temperature of 160 °C for 8 h. The developed method was validated through repeatability and intermediate precision studies, which yielded a coefficient of variation lower than 5%. The recovery and reuse of DES were successfully evaluated, revealing remarkable fractionation yields even after five cycles. This work demonstrates the feasibility of selectively extracting lignin and cellulose from woody biomass using a sustainable solvent, thus paving the way for valorization of invasive species biomass.

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Surface Tuning of Wood via Covalent Modification of Its Lignocellulosic Biopolymers with Substituted Benzoates─A Study on Reactivity, Efficiency, and Durability

Cited by 3 publications

References 54 publications

Design and Synthesis of Stem Cell-Laden Keratin/Glycol Chitosan Methacrylate Bioinks for 3D Bioprinting

Design and Synthesis of Stem Cell-Laden Keratin/Glycol Chitosan Methacrylate Bioinks for 3D Bioprinting

Synthesis of N-acylbenzotriazole using acid anhydride

Enhancing Cellulose and Lignin Fractionation from Acacia Wood: Optimized Parameters Using a Deep Eutectic Solvent System and Solvent Recovery

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