Surface wetting driven release of antifibrotic Mitomycin-C drug from modified biopolymer thin films

Abstract

We demonstrate that Nature-inspired lotus-like non-wetting phenomena can also be used in the field of controlled drug delivery. Hydrophobically modified, and cellulose microparticle-roughened polyvinyl alcohol (PVA) biopolymer based thin films were synthetised and converted into superhydrophobic (Θ=165.3°; [[EQUATION]] = 1.7±0.67 mJ/m 2 ) thin films. The surface wetting of the thin films was adjustable from superhydrophilic to superhydrophobic nature and this affected the drug release properties as well. We also prove that this surface wetting driven drug delivery system (DDS) is suitable for the encapsulation and prolonged/ adjusted release of Mitomycin (MMC), a drug with antifibrotic properties. The in vitro release experiments conducted under physiological conditions (PBS, pH = 7.4) revealed that -due to the lower crystallinity-the release of MMC was faster (k'=6.1×10 -6 mM/s) from the hydrophilic film compared to the pure, crystalline (k'=1.21×10 -6 mM/s) MMC. Neverteless, significantly lower MMC dissolution rate (k'=5×10 -8 mM/s) was obtained for the superhydrophobic sample featuring a non-wetting, lotus-like nature. Based on this in vitro study, we suggest that the presented surface wetting driven DDS loaded with MMC could be useful for example in the area of head and neck surgeries to prevent scar tissue formation.

Use of Self-Assembled Colloidal Prodrug Nanoparticles for Controlled Drug Delivery of Anticancer, Antifibrotic and Antibacterial Mitomycin

“…As shown in Figure 1 , the initial PVA was functionalized with various molar ratios (from 8 to 126 molar %) of succinic anhydride to the PVA’s OH groups (15.8 mmol/g, determined by acetic anhydride/pyridine titration [ 25 ]).…”

“…The main characteristic peaks of PVA were 3280 cm −1 (O–H stretching vibration), 2960 cm –1 (CH 2 asymmetric stretching vibration), 2925 cm −1 (CH 2 symmetric stretching vibration), 1735 cm −1 (C=O carbonyl stretch), 1425 cm −1 (C–H bending vibration of CH 2 ), 1380 cm −1 (C–H deformation vibration), 1325 cm −1 (CH 2 wagging vibration), 1245 cm −1 (C–O–C stretching vibration), 1100 cm −1 (C–O stretching of acetyl groups), and 840 cm −1 (C−C stretching vibration) [ 25 , 27 , 28 ]. It was obvious that when the OH groups of the PVA backbone were modified by succinyl moieties, the OH-stretching band of pure PVA (~3280 cm −1 ) diminished, and the emergence of significant absorption bands at 1735 and 1670 cm −1 , which were associated with the esteric carbonyls and carboxylate moieties, respectively, characterized the difference between these two spectra [ 29 ].…”

Self-Assembling Injectable Hydrogel for Controlled Drug Delivery of Antimuscular Atrophy Drug Tilorone

“…The successful modification of the initial polymers was confirmed by the FTIR measurements as shown in Figure 2. The main characteristic peaks of PVA were 3280 cm −1 (O-H stretching vibration), 2960 cm −1 (CH 2 asymmetric stretching vibration), 2925 cm −1 (CH 2 symmetric stretching vibration), 1735 cm −1 (C=O carbonyl stretching vibration), 1425 cm −1 (C-H bending vibration of CH 2 ), 1380 cm −1 (C-H deformation vibration), 1325 cm −1 (CH 2 wagging vibration), 1245 cm −1 (C-O-C stretching vibration), 1100 cm −1 (C-O stretching of acetyl groups), and 840 cm −1 (C-C stretching vibration) [24,40,41]. The modification reaction was confirmed by the appearance of the C=O stretching vibration of the aldehyde at 1705 cm -1 which overlapped with the ester (C=O) carbonyl at 1730 cm -1 .…”

Development of Drug Customized Polymeric Carriers for Improved Therapeutic Efficiency

“…The initial PVA with OH groups was chemically modified as shown in Figure 10 by appending succinic anhydride in a range of molar ratios (8 -126 molar%) to the OH groups of PVA (15.8 mmol/g, as assessed by the acetic anhydride/pyridine titration [231,232]).…”